ARMD4_HUMAN
ID ARMD4_HUMAN Reviewed; 774 AA.
AC Q86TY3; A8K8Z8; Q6P5Q1; Q86TY1;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Armadillo-like helical domain-containing protein 4 {ECO:0000305};
DE Flags: Precursor;
GN Name=ARMH4 {ECO:0000312|HGNC:HGNC:19846};
GN Synonyms=C14orf37 {ECO:0000312|HGNC:HGNC:19846};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Neuroblastoma, and Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-769 AND SER-770, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q86TY3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86TY3-2; Sequence=VSP_020882, VSP_020883;
CC Name=3;
CC IsoId=Q86TY3-3; Sequence=VSP_020881;
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DR EMBL; BX161411; CAD61887.1; -; mRNA.
DR EMBL; BX161448; CAD61913.1; -; mRNA.
DR EMBL; AK292513; BAF85202.1; -; mRNA.
DR EMBL; CH471061; EAW80713.1; -; Genomic_DNA.
DR EMBL; BC062772; AAH62772.1; -; mRNA.
DR CCDS; CCDS32089.1; -. [Q86TY3-1]
DR RefSeq; NP_001001872.2; NM_001001872.3. [Q86TY3-1]
DR RefSeq; NP_001307102.1; NM_001320173.1. [Q86TY3-2]
DR RefSeq; XP_016876518.1; XM_017021029.1. [Q86TY3-1]
DR AlphaFoldDB; Q86TY3; -.
DR BioGRID; 126910; 20.
DR IntAct; Q86TY3; 6.
DR STRING; 9606.ENSP00000267485; -.
DR GlyGen; Q86TY3; 21 sites, 3 O-linked glycans (19 sites).
DR iPTMnet; Q86TY3; -.
DR PhosphoSitePlus; Q86TY3; -.
DR BioMuta; C14orf37; -.
DR DMDM; 74750397; -.
DR jPOST; Q86TY3; -.
DR MassIVE; Q86TY3; -.
DR PaxDb; Q86TY3; -.
DR PeptideAtlas; Q86TY3; -.
DR PRIDE; Q86TY3; -.
DR ProteomicsDB; 69744; -. [Q86TY3-1]
DR ProteomicsDB; 69745; -. [Q86TY3-2]
DR ProteomicsDB; 69746; -. [Q86TY3-3]
DR Antibodypedia; 77; 36 antibodies from 15 providers.
DR DNASU; 145407; -.
DR Ensembl; ENST00000267485.7; ENSP00000267485.7; ENSG00000139971.15. [Q86TY3-1]
DR GeneID; 145407; -.
DR KEGG; hsa:145407; -.
DR MANE-Select; ENST00000267485.7; ENSP00000267485.7; NM_001001872.4; NP_001001872.2.
DR UCSC; uc001xdc.4; human. [Q86TY3-1]
DR CTD; 145407; -.
DR DisGeNET; 145407; -.
DR GeneCards; ARMH4; -.
DR HGNC; HGNC:19846; ARMH4.
DR HPA; ENSG00000139971; Tissue enhanced (brain, kidney).
DR neXtProt; NX_Q86TY3; -.
DR OpenTargets; ENSG00000139971; -.
DR PharmGKB; PA134941886; -.
DR VEuPathDB; HostDB:ENSG00000139971; -.
DR eggNOG; ENOG502QWJQ; Eukaryota.
DR GeneTree; ENSGT00390000012816; -.
DR HOGENOM; CLU_021688_0_0_1; -.
DR InParanoid; Q86TY3; -.
DR OMA; CLAFPKI; -.
DR OrthoDB; 315961at2759; -.
DR PhylomeDB; Q86TY3; -.
DR TreeFam; TF336099; -.
DR PathwayCommons; Q86TY3; -.
DR SignaLink; Q86TY3; -.
DR BioGRID-ORCS; 145407; 6 hits in 1052 CRISPR screens.
DR ChiTaRS; C14orf37; human.
DR GenomeRNAi; 145407; -.
DR Pharos; Q86TY3; Tdark.
DR PRO; PR:Q86TY3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q86TY3; protein.
DR Bgee; ENSG00000139971; Expressed in cortical plate and 134 other tissues.
DR ExpressionAtlas; Q86TY3; baseline and differential.
DR Genevisible; Q86TY3; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031524; ARMH4.
DR PANTHER; PTHR21585; PTHR21585; 1.
DR Pfam; PF15767; DUF4696; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..774
FT /note="Armadillo-like helical domain-containing protein 4"
FT /id="PRO_0000252152"
FT TOPO_DOM 28..714
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 715..735
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 736..774
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 41..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..648
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 769
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 770
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..542
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020881"
FT VAR_SEQ 612..670
FT /note="GQEDEDEEDEEDEDEEEEDEEEDEEDKDADSLDEGLDGDTELPGFTLPGITS
FT QEPGLEE -> TGFHHVAQARLKLLGLRSLPASASQSVGITSVNSCTQPRKYLNSCLKW
FT KLNPKHFATGV (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_020882"
FT VAR_SEQ 671..774
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_020883"
FT VARIANT 96
FT /note="T -> I (in dbSNP:rs3829765)"
FT /id="VAR_027782"
FT VARIANT 391
FT /note="A -> V (in dbSNP:rs1018504)"
FT /id="VAR_027783"
FT VARIANT 528
FT /note="V -> F (in dbSNP:rs12886921)"
FT /id="VAR_027784"
FT VARIANT 613
FT /note="Q -> E (in dbSNP:rs2273442)"
FT /id="VAR_027785"
FT CONFLICT 753
FT /note="Missing (in Ref. 4; AAH62772)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 774 AA; 84173 MW; 0A74F08DF9BF5791 CRC64;
MRGPIVLHIC LAFCSLLLFS VATQCLAFPK IERRREIAHV HAEKGQSDKM NTDDLENSSV
TSKQTPQLVV SEDPMMMSAV PSATSLNKAF SINKETQPGQ AGLMQTERPG VSTPTESGVP
SAEEVFGSSQ PERISPESGL AKAMLTIAIT ATPSLTVDEK EELLTSTNFQ PIVEEITETT
KGFLKYMDNQ SFATESQEGV GLGHSPSSYV NTKEMLTTNP KTEKFEADTD HRTTSFPGAE
STAGSEPGSL TPDKEKPSQM TADNTQAAAT KQPLETSEYT LSVEPETDSL LGAPEVTVSV
STAVPAASAL SDEWDDTKLE SVSRIRTPKL GDNEETQVRT EMSQTAQVSH EGMEGGQPWT
EAAQVALGLP EGETHTGTAL LIAHGNERSP AFTDQSSFTP TSLMEDMKVS IVNLLQSTGD
FTESTKENDA LFFLETTVSV SVYESEADQL LGNTMKDIIT QEMTTAVQEP DATLSMVTQE
QVATLELIRD SGKTEEEKED PSPVSDVPGV TQLSRRWEPL ATTISTTVVP LSFEVTPTVE
EQMDTVTGPN EEFTPVLGSP VTPPGIMVGE PSISPALPAL EASSERRTVV PSITRVNTAA
SYGLDQLESE EGQEDEDEED EEDEDEEEED EEEDEEDKDA DSLDEGLDGD TELPGFTLPG
ITSQEPGLEE GNMDLLEGAT YQVPDALEWE QQNQGLVRSW MEKLKDKAGY MSGMLVPVGV
GIAGALFILG ALYSIKVMNR RRRNGFKRHK RKQREFNSMQ DRVMLLADSS EDEF
