ARMD4_MOUSE
ID ARMD4_MOUSE Reviewed; 775 AA.
AC Q8BT18; Q8BFQ7; Q8R1Q5; Q9D6C5;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Armadillo-like helical domain-containing protein 4 {ECO:0000250|UniProtKB:Q86TY3};
DE Flags: Precursor;
GN Name=Armh4 {ECO:0000250|UniProtKB:Q86TY3};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, Embryo, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK014402; BAB29326.1; -; mRNA.
DR EMBL; AK028180; BAC25793.1; -; mRNA.
DR EMBL; AK032093; BAC27694.1; -; mRNA.
DR EMBL; AK049427; BAC33748.1; -; mRNA.
DR EMBL; BC023359; AAH23359.1; -; mRNA.
DR CCDS; CCDS36903.1; -.
DR RefSeq; NP_080418.2; NM_026142.4.
DR AlphaFoldDB; Q8BT18; -.
DR STRING; 10090.ENSMUSP00000036220; -.
DR GlyGen; Q8BT18; 2 sites.
DR iPTMnet; Q8BT18; -.
DR PhosphoSitePlus; Q8BT18; -.
DR CPTAC; non-CPTAC-3453; -.
DR PaxDb; Q8BT18; -.
DR PRIDE; Q8BT18; -.
DR Antibodypedia; 77; 36 antibodies from 15 providers.
DR DNASU; 67419; -.
DR Ensembl; ENSMUST00000036972; ENSMUSP00000036220; ENSMUSG00000036242.
DR GeneID; 67419; -.
DR KEGG; mmu:67419; -.
DR UCSC; uc007tkk.2; mouse.
DR CTD; 145407; -.
DR MGI; MGI:1914669; Armh4.
DR VEuPathDB; HostDB:ENSMUSG00000036242; -.
DR eggNOG; ENOG502QWJQ; Eukaryota.
DR GeneTree; ENSGT00390000012816; -.
DR HOGENOM; CLU_021688_0_0_1; -.
DR InParanoid; Q8BT18; -.
DR OMA; CLAFPKI; -.
DR OrthoDB; 315961at2759; -.
DR PhylomeDB; Q8BT18; -.
DR TreeFam; TF336099; -.
DR BioGRID-ORCS; 67419; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Armh4; mouse.
DR PRO; PR:Q8BT18; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BT18; protein.
DR Bgee; ENSMUSG00000036242; Expressed in humerus cartilage element and 241 other tissues.
DR ExpressionAtlas; Q8BT18; baseline and differential.
DR Genevisible; Q8BT18; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031524; ARMH4.
DR PANTHER; PTHR21585; PTHR21585; 1.
DR Pfam; PF15767; DUF4696; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..47
FT /evidence="ECO:0000255"
FT CHAIN 48..775
FT /note="Armadillo-like helical domain-containing protein 4"
FT /id="PRO_0000252153"
FT TOPO_DOM 48..715
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 716..736
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 737..775
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 120..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..642
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 770
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86TY3"
FT MOD_RES 771
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86TY3"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 102
FT /note="E -> G (in Ref. 1; BAB29326)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="I -> H (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 137
FT /note="V -> A (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 140
FT /note="A -> P (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="V -> A (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 183
FT /note="N -> D (in Ref. 1; BAB29326)"
FT /evidence="ECO:0000305"
FT CONFLICT 206..208
FT /note="DNQ -> NNH (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 228
FT /note="I -> V (in Ref. 1; BAB29326)"
FT /evidence="ECO:0000305"
FT CONFLICT 247
FT /note="V -> F (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="M -> T (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="M -> N (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 286
FT /note="F -> V (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 351
FT /note="G -> A (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 468
FT /note="R -> I (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 479
FT /note="S -> F (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 522
FT /note="G -> W (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 544
FT /note="M -> V (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 583
FT /note="P -> L (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="S -> C (in Ref. 1; BAC25793)"
FT /evidence="ECO:0000305"
FT CONFLICT 621
FT /note="Missing (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 671
FT /note="S -> P (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
FT CONFLICT 754
FT /note="Missing (in Ref. 1; BAC25793)"
FT /evidence="ECO:0000305"
FT CONFLICT 771
FT /note="S -> F (in Ref. 2; AAH23359)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 775 AA; 83774 MW; FC7D04D0EFE12693 CRC64;
MLQDSITGIV NSFNLFFPST MSRPTLMPTC VAFCSILFLT LATGCQAFPK VERRETAQEY
AEKEQSQKMN TDDQENISFA PKYMLQQMSS EAPMVLSEGP SEIPLIKVFS VNKESHLPGA
GLLHPTSPGV YSSSEPVVSA SEQEPGPSLL ERMSSEHSLS KVMLTVAVSS PASLNPDQEG
PYNSLSTQPI VAAVTDVTHG SLDYLDNQLF AAKSQEAVSL GNSPSSSINT KEPEIIKADA
AMGTTVVPGV DSTGDMEPDR ERPSEMAADD GQSTTTKYLV TIPNNFLTTE PTAGSILGDA
KVTVSVSTAG PVSSIFNEEW DDTKFESISR GRPPEPGDNA ETQMRTKPPH GTYESFEGTE
ESPSSTAVLK VAPGHLGGEP ALGTALVTAL GDERSPVLTH QISFTPMSLA EDPEVSTMKL
FPSAGGFRAS TQGDRTQLSS ETAFSTSQYE SVPQQEAGNV LKDITQERKM ATQAMNTTSP
VVTQEHMATI EVPRGSGEPE EGMPSLSPVP AEVADAELSR RGESLATPAS TTVVPLSLKL
TSSMEDLMDT ITGPSEEFIP VLGSPMAPPA MTVEAPTISS ALPSEGRTSP SISRPNTAAS
YGLEQLESEE VEDDEDEEDE EDEEEEEEDE EDEEDEEDKE TDSLYKDFDG DTEPPGFTLP
GITSQEPDIR SGSMDLLEVA TYQVPETIEW EQQNQGLVRS WMEKLKDKAG YMSGMLVPVG
VGIAGALFIL GALYSIKVMN RRRRNGFKRH KRKQREFNSM QDRVMLLADS SEDEF
