ID   ARMET_DROPS             Reviewed;         173 AA.
AC   Q295V5;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor homolog;
DE   AltName: Full=MANF/CDNF-like protein;
DE   Flags: Precursor;
GN   Name=Manf {ECO:0000250|UniProtKB:Q9XZ63}; ORFNames=GA20031;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL28603.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: Required during the maturation of the embryonic nervous
CC       system for maintenance of neuronal and cuticular connectivity.
CC       Essential for maintenance of dopaminergic neurons and dopamine levels
CC       (By similarity). {ECO:0000250|UniProtKB:Q9XZ63}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9XZ63}.
CC   -!- SIMILARITY: Belongs to the ARMET family. {ECO:0000255}.
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DR   EMBL; CM000070; EAL28603.1; -; Genomic_DNA.
DR   RefSeq; XP_001359457.1; XM_001359420.4.
DR   AlphaFoldDB; Q295V5; -.
DR   SMR; Q295V5; -.
DR   STRING; 7237.FBpp0281494; -.
DR   EnsemblMetazoa; FBtr0283056; FBpp0281494; FBgn0080027.
DR   GeneID; 4802560; -.
DR   KEGG; dpo:Dpse_GA20031; -.
DR   eggNOG; KOG4154; Eukaryota.
DR   HOGENOM; CLU_099080_1_0_1; -.
DR   InParanoid; Q295V5; -.
DR   OMA; VCKKVLD; -.
DR   PhylomeDB; Q295V5; -.
DR   ChiTaRS; Manf; fly.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0080027; Expressed in male reproductive system and 2 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0042417; P:dopamine metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0070050; P:neuron cellular homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0031175; P:neuron projection development; IEA:EnsemblMetazoa.
DR   GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.720.30; -; 1.
DR   InterPro; IPR045333; ARMET-like.
DR   InterPro; IPR019345; ARMET_C.
DR   InterPro; IPR045332; ARMET_N.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   PANTHER; PTHR12990; PTHR12990; 1.
DR   Pfam; PF10208; ARMET_C; 1.
DR   Pfam; PF20145; ARMET_N; 1.
DR   SUPFAM; SSF68906; SSF68906; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..173
FT                   /note="Mesencephalic astrocyte-derived neurotrophic factor
FT                   homolog"
FT                   /id="PRO_0000390943"
FT   DISULFID        28..114
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        31..103
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        61..72
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        148..151
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
SQ   SEQUENCE   173 AA;  20024 MW;  4B07E72130474226 CRC64;
     MKTTHLVLVL CFLAGVAQTT LALKEEDCEV CIKTVRRFAA SLDDAIKGDY KQIETEFKKF
     CKTQKNKEHR FCYYLGGLEE SATGILNEMS KPLSWSMPAE KVCEKLKKKD AQICDLRYEK
     QIDLNSVDLK KLKVRDLKKI LNDWDESCDG CLEKSDFIKR IEELKPKYAR SEL