ID   ARMET_DROSI             Reviewed;         173 AA.
AC   B4QX46;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Mesencephalic astrocyte-derived neurotrophic factor homolog;
DE   AltName: Full=MANF/CDNF-like protein;
DE   Flags: Precursor;
GN   Name=Manf {ECO:0000250|UniProtKB:Q9XZ63}; ORFNames=GD19093;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240;
RN   [1] {ECO:0000312|EMBL:EDX12700.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Required during the maturation of the embryonic nervous
CC       system for maintenance of neuronal and cuticular connectivity.
CC       Essential for maintenance of dopaminergic neurons and dopamine levels
CC       (By similarity). {ECO:0000250|UniProtKB:Q9XZ63}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9XZ63}.
CC   -!- SIMILARITY: Belongs to the ARMET family. {ECO:0000255}.
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DR   EMBL; CM000364; EDX12700.1; -; Genomic_DNA.
DR   RefSeq; XP_002103197.1; XM_002103161.2.
DR   AlphaFoldDB; B4QX46; -.
DR   SMR; B4QX46; -.
DR   STRING; 7240.B4QX46; -.
DR   EnsemblMetazoa; FBtr0219003; FBpp0217495; FBgn0190600.
DR   GeneID; 6727838; -.
DR   HOGENOM; CLU_099080_1_0_1; -.
DR   OMA; ECEVCVS; -.
DR   PhylomeDB; B4QX46; -.
DR   ChiTaRS; Manf; fly.
DR   Proteomes; UP000000304; Chromosome 3r.
DR   Bgee; FBgn0190600; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0042417; P:dopamine metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0070050; P:neuron cellular homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0031175; P:neuron projection development; IEA:EnsemblMetazoa.
DR   GO; GO:0001963; P:synaptic transmission, dopaminergic; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.720.30; -; 1.
DR   InterPro; IPR045333; ARMET-like.
DR   InterPro; IPR019345; ARMET_C.
DR   InterPro; IPR045332; ARMET_N.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR036361; SAP_dom_sf.
DR   PANTHER; PTHR12990; PTHR12990; 1.
DR   Pfam; PF10208; ARMET_C; 1.
DR   Pfam; PF20145; ARMET_N; 1.
DR   SUPFAM; SSF68906; SSF68906; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..173
FT                   /note="Mesencephalic astrocyte-derived neurotrophic factor
FT                   homolog"
FT                   /id="PRO_0000390945"
FT   DISULFID        28..114
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        31..103
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        61..72
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
FT   DISULFID        148..151
FT                   /evidence="ECO:0000250|UniProtKB:P55145"
SQ   SEQUENCE   173 AA;  20110 MW;  F371BC3A915A0197 CRC64;
     MKTWHMVVVI GFLATLAQTS LALKEEDCEV CVKTVRRFAD SLDDSTKKDY KQIETAFKKF
     CKAQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE KICEKLKKKD AQICDLRYEK
     QIDLNSVDLK KLKVRDLKKI LNDWDESCDG CLEKGDFIKR IEELKPKYSR SEL