ARMX1_MOUSE
ID ARMX1_MOUSE Reviewed; 456 AA.
AC Q9CX83;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Armadillo repeat-containing X-linked protein 1;
GN Name=Armcx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N-3; TISSUE=Brain, Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22569362; DOI=10.1038/ncomms1829;
RA Lopez-Domenech G., Serrat R., Mirra S., D'Aniello S., Somorjai I., Abad A.,
RA Vitureira N., Garcia-Arumi E., Alonso M.T., Rodriguez-Prados M.,
RA Burgaya F., Andreu A.L., Garcia-Sancho J., Trullas R., Garcia-Fernandez J.,
RA Soriano E.;
RT "The eutherian Armcx genes regulate mitochondrial trafficking in neurons
RT and interact with Miro and Trak2.";
RL Nat. Commun. 3:814-814(2012).
RN [4]
RP SUBCELLULAR LOCATION, INDUCTION, AND INTERACTION WITH MIRO1.
RX PubMed=28009275; DOI=10.1016/j.neuron.2016.10.060;
RA Cartoni R., Norsworthy M.W., Bei F., Wang C., Li S., Zhang Y., Gabel C.V.,
RA Schwarz T.L., He Z.;
RT "The mammalian-specific protein Armcx1 regulates mitochondrial transport
RT during axon regeneration.";
RL Neuron 92:1294-1307(2016).
RN [5]
RP ERRATUM OF PUBMED:28009275.
RX PubMed=28472662; DOI=10.1016/j.neuron.2017.04.028;
RA Cartoni R., Norsworthy M.W., Bei F., Wang C., Li S., Zhang Y., Gabel C.V.,
RA Schwarz T.L., He Z.;
RL Neuron 94:689-689(2017).
CC -!- FUNCTION: Regulates mitochondrial transport during axon regeneration.
CC Increases the proportion of motile mitochondria by recruiting
CC stationary mitochondria into the motile pool. Enhances mitochondria
CC movement and neurite growth in both adult axons and embryonic neurons.
CC Promotes neuronal survival and axon regeneration after nerve injury.
CC May link mitochondria to the Trak1-kinesin motor complex via its
CC interaction with Miro1. {ECO:0000269|PubMed:28009275}.
CC -!- SUBUNIT: Interacts with MIRO1. {ECO:0000269|PubMed:28009275}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22569362,
CC ECO:0000269|PubMed:28009275}. Mitochondrion outer membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Widely expressed in the adult nervous tissue,
CC especially in the forebrain, including the cerebral cortex, hippocampus
CC and thalamus. {ECO:0000269|PubMed:22569362}.
CC -!- INDUCTION: After axonal injury. {ECO:0000269|PubMed:28009275}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
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DR EMBL; AK019405; BAB31705.1; -; mRNA.
DR EMBL; AK147002; BAE27599.1; -; mRNA.
DR EMBL; BC021410; AAH21410.1; -; mRNA.
DR EMBL; BC026488; AAH26488.1; -; mRNA.
DR EMBL; BC068228; AAH68228.1; -; mRNA.
DR CCDS; CCDS30398.1; -.
DR RefSeq; NP_001159849.1; NM_001166377.1.
DR RefSeq; NP_001159850.1; NM_001166378.1.
DR RefSeq; NP_001159851.1; NM_001166379.1.
DR RefSeq; NP_001159852.1; NM_001166380.1.
DR RefSeq; NP_084342.1; NM_030066.3.
DR RefSeq; XP_006528687.1; XM_006528624.2.
DR RefSeq; XP_006528688.1; XM_006528625.2.
DR RefSeq; XP_006528689.1; XM_006528626.2.
DR RefSeq; XP_006528690.1; XM_006528627.2.
DR AlphaFoldDB; Q9CX83; -.
DR SMR; Q9CX83; -.
DR BioGRID; 219279; 1.
DR STRING; 10090.ENSMUSP00000108824; -.
DR iPTMnet; Q9CX83; -.
DR PhosphoSitePlus; Q9CX83; -.
DR MaxQB; Q9CX83; -.
DR PaxDb; Q9CX83; -.
DR PeptideAtlas; Q9CX83; -.
DR PRIDE; Q9CX83; -.
DR ProteomicsDB; 277304; -.
DR Antibodypedia; 28759; 250 antibodies from 29 providers.
DR DNASU; 78248; -.
DR Ensembl; ENSMUST00000035748; ENSMUSP00000043965; ENSMUSG00000033460.
DR Ensembl; ENSMUST00000051256; ENSMUSP00000053909; ENSMUSG00000033460.
DR Ensembl; ENSMUST00000113197; ENSMUSP00000108822; ENSMUSG00000033460.
DR Ensembl; ENSMUST00000113198; ENSMUSP00000108823; ENSMUSG00000033460.
DR Ensembl; ENSMUST00000113199; ENSMUSP00000108824; ENSMUSG00000033460.
DR Ensembl; ENSMUST00000113201; ENSMUSP00000108826; ENSMUSG00000033460.
DR GeneID; 78248; -.
DR KEGG; mmu:78248; -.
DR UCSC; uc009ugj.2; mouse.
DR CTD; 51309; -.
DR MGI; MGI:1925498; Armcx1.
DR VEuPathDB; HostDB:ENSMUSG00000033460; -.
DR eggNOG; ENOG502QYZW; Eukaryota.
DR GeneTree; ENSGT00940000162561; -.
DR HOGENOM; CLU_037187_0_0_1; -.
DR InParanoid; Q9CX83; -.
DR OMA; DVKAEAH; -.
DR OrthoDB; 860703at2759; -.
DR PhylomeDB; Q9CX83; -.
DR TreeFam; TF335652; -.
DR BioGRID-ORCS; 78248; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q9CX83; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9CX83; protein.
DR Bgee; ENSMUSG00000033460; Expressed in superior cervical ganglion and 236 other tissues.
DR Genevisible; Q9CX83; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IMP:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF04826; Arm_2; 1.
DR SMART; SM00185; ARM; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..456
FT /note="Armadillo repeat-containing X-linked protein 1"
FT /id="PRO_0000191362"
FT TOPO_DOM 1..6
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT TRANSMEM 7..29
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..456
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT REPEAT 198..238
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 240..279
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 361..401
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 418..456
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REGION 1..6
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305|PubMed:22569362"
FT REGION 26..36
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305|PubMed:22569362"
FT REGION 37..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..180
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 50643 MW; 159EFAEF1B536406 CRC64;
MGRTREAGCV AAGMVIGAGA CYCVYRLTWG KDENEKLWDE EEEEEEEEEE KSCSDKTEKE
LKTNVGVGAR GKPQDDSKSK VEVNVGPENG PGVKKEVHPE SQSGGGLEAK AKALFKTLKE
QARAKAGRGI RLPNISRNRT LTSSLPCPGG RGGGCHPGRT GSRARNRTSG KVKRKNRSKS
NKAPATAWPV RKGKFSFPYK IDDILSAPDL QKVLNILERT NDPFTQEVAL VTLGNNAAYS
FNQNAIRELG GVPIIAKLIK TRDPIIREKT YNALNNLSVN SENQGKIKTY ISQVCDDTMV
CRLDSAVQMA GLRLLTNMTV TNHYQHLLSY SFPDFFALLF LGNHFTKIQT MKLIINFTEN
PAMTRELVSC KVPSELISLF NKEWDREILL NILTLFENIN DNIKSEGLAS SRKEFSRSSL
FFLFKESGVC VKKIKALASH KDLVVKVKVL KVLTKL
