ID   ARMX1_PONAB             Reviewed;         453 AA.
AC   Q5R4B2;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Armadillo repeat-containing X-linked protein 1;
GN   Name=ARMCX1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates mitochondrial transport during axon regeneration.
CC       Increases the proportion of motile mitochondria by recruiting
CC       stationary mitochondria into the motile pool. Enhances mitochondria
CC       movement and neurite growth in both adult axons and embryonic neurons.
CC       Promotes neuronal survival and axon regeneration after nerve injury.
CC       May link mitochondria to the Trak1-kinesin motor complex via its
CC       interaction with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.
CC   -!- SUBUNIT: Interacts with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9CX83}.
CC       Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9CX83}; Single-
CC       pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC       family. {ECO:0000305}.
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DR   EMBL; CR861343; CAH93404.1; -; mRNA.
DR   RefSeq; NP_001126998.1; NM_001133526.1.
DR   AlphaFoldDB; Q5R4B2; -.
DR   SMR; Q5R4B2; -.
DR   STRING; 9601.ENSPPYP00000023011; -.
DR   GeneID; 100174021; -.
DR   KEGG; pon:100174021; -.
DR   CTD; 51309; -.
DR   eggNOG; ENOG502QYZW; Eukaryota.
DR   InParanoid; Q5R4B2; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   Pfam; PF04826; Arm_2; 1.
DR   SMART; SM00185; ARM; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..453
FT                   /note="Armadillo repeat-containing X-linked protein 1"
FT                   /id="PRO_0000191361"
FT   TOPO_DOM        1..6
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT   TRANSMEM        7..29
FT                   /note="Helical; Signal-anchor"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..453
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT   REPEAT          195..235
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          237..276
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          358..398
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          415..453
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REGION          1..6
FT                   /note="Mitochondrion outer membrane (MOM)-targeting
FT                   sequence"
FT                   /evidence="ECO:0000305"
FT   REGION          26..36
FT                   /note="Mitochondrion outer membrane (MOM)-targeting
FT                   sequence"
FT                   /evidence="ECO:0000305"
FT   REGION          140..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  49351 MW;  DCE8F7AA88C14CB8 CRC64;
     MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI GVETVKGAKT
     SVGAGSGVKL QGDSKVKPEV NLGLEDCPGV KEKAHSGSHR GGGLEAKAKA LFNTLKEQAS
     AKAGKGARMG TITGNRTLAP SLPCPGGRGG GCHPTRSGSR AGGRASGKSK GKARSKSTRA
     PATTWPVRRG KFNFPYKIDD ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ
     NAIRELGGVP IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL
     DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL IINFTENPAM
     TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI KNEGLASSRK EFSRSSLFFL
     FKESGVCVKK IKALANHNDL VVKVKVLKVL TKL