ARMX1_RAT
ID ARMX1_RAT Reviewed; 461 AA.
AC Q5U310;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Armadillo repeat-containing X-linked protein 1;
GN Name=Armcx1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Regulates mitochondrial transport during axon regeneration.
CC Increases the proportion of motile mitochondria by recruiting
CC stationary mitochondria into the motile pool. Enhances mitochondria
CC movement and neurite growth in both adult axons and embryonic neurons.
CC Promotes neuronal survival and axon regeneration after nerve injury.
CC May link mitochondria to the Trak1-kinesin motor complex via its
CC interaction with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.
CC -!- SUBUNIT: Interacts with MIRO1. {ECO:0000250|UniProtKB:Q9CX83}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9CX83}.
CC Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9CX83}; Single-
CC pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
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DR EMBL; BC085780; AAH85780.1; -; mRNA.
DR RefSeq; NP_001019538.1; NM_001024367.1.
DR RefSeq; XP_006257305.1; XM_006257243.3.
DR RefSeq; XP_006257315.1; XM_006257253.3.
DR RefSeq; XP_017457844.1; XM_017602355.1.
DR AlphaFoldDB; Q5U310; -.
DR SMR; Q5U310; -.
DR STRING; 10116.ENSRNOP00000030952; -.
DR PaxDb; Q5U310; -.
DR Ensembl; ENSRNOT00000029833; ENSRNOP00000030952; ENSRNOG00000046862.
DR Ensembl; ENSRNOT00000052422; ENSRNOP00000043675; ENSRNOG00000046862.
DR GeneID; 501619; -.
DR KEGG; rno:501619; -.
DR UCSC; RGD:1561629; rat.
DR CTD; 51309; -.
DR RGD; 1561629; Armcx1.
DR eggNOG; ENOG502QYZW; Eukaryota.
DR GeneTree; ENSGT00940000162561; -.
DR HOGENOM; CLU_037187_0_0_1; -.
DR InParanoid; Q5U310; -.
DR OMA; DVKAEAH; -.
DR OrthoDB; 860703at2759; -.
DR PhylomeDB; Q5U310; -.
DR TreeFam; TF335652; -.
DR PRO; PR:Q5U310; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000037709; Expressed in cerebellum and 18 other tissues.
DR Genevisible; Q5U310; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; ISO:RGD.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF04826; Arm_2; 1.
DR SMART; SM00185; ARM; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Repeat; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..461
FT /note="Armadillo repeat-containing X-linked protein 1"
FT /id="PRO_0000191363"
FT TOPO_DOM 1..6
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT TRANSMEM 7..29
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..461
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT REPEAT 203..243
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 245..284
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 366..406
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 423..461
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REGION 1..6
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305"
FT REGION 26..36
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305"
FT REGION 34..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..52
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..185
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 51049 MW; B3E2E9836CD950C4 CRC64;
MGRTREAGCV AAGMVIGAGA CYCVYRLTWG KDENEKLWDD EDEEEEEEEE SCSGKPEIGG
KTVKERKTHV GVGAGAKPQD DSKSKAEANV GPENGPDVKK EVYPESHSEG GLEAKAKALF
KSLKEQASAK AGRGIRFPNI SRIRTLTSSL PCPGGRGGGC HPGRTGSRAR NRTSGKVKRK
NRSKSNKAPA TAWPVRRGKF SFPYKIDDIL SAPDLQKVLN ILERTNDPFT QEVALVTLGN
NAAYSFNQNA IRELGGVPII AKLIKTRDPI IREKTYNALN NLSVNSENQG KIKTYISQVC
DDTMVCRLDS AVQMAGLRLL TNMTVTNHYQ HLLSYSFPDF FALLFLGNHF TKIQTMKLII
NFTENPAMTR ELVSCKVPSE LISLFNKEWD REILLNILTL FENINDNIKS EGLASSRKEF
SRSSLFFLFK ESGVCVKKIK ALASHKDLVV KVKVLKVLTK L
