ARMX3_PONAB
ID ARMX3_PONAB Reviewed; 379 AA.
AC Q5R9J3;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Armadillo repeat-containing X-linked protein 3;
GN Name=ARMCX3;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates mitochondrial aggregation and transport in axons in
CC living neurons. May link mitochondria to the TRAK2-kinesin motor
CC complex via its interaction with Miro and TRAK2. Mitochondrial
CC distribution and dynamics is regulated through ARMCX3 protein
CC degradation, which is promoted by PCK and negatively regulated by WNT1.
CC Enhances the SOX10-mediated transactivation of the neuronal
CC acetylcholine receptor subunit alpha-3 and beta-4 subunit gene
CC promoters. {ECO:0000250|UniProtKB:Q8BHS6}.
CC -!- SUBUNIT: Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The
CC interaction with Miro is calcium-dependent. Interacts with SOX10.
CC {ECO:0000250|UniProtKB:Q8BHS6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q8BHS6}; Single-pass membrane protein
CC {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8BHS6}. Nucleus
CC {ECO:0000250|UniProtKB:Q8BHS6}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
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DR EMBL; CR859394; CAH91567.1; -; mRNA.
DR RefSeq; NP_001125920.1; NM_001132448.1.
DR RefSeq; XP_009233344.1; XM_009235069.1.
DR RefSeq; XP_009233346.1; XM_009235071.1.
DR AlphaFoldDB; Q5R9J3; -.
DR SMR; Q5R9J3; -.
DR STRING; 9601.ENSPPYP00000023013; -.
DR Ensembl; ENSPPYT00000023981; ENSPPYP00000023013; ENSPPYG00000020558.
DR Ensembl; ENSPPYT00000062200; ENSPPYP00000030579; ENSPPYG00000020558.
DR GeneID; 100172854; -.
DR KEGG; pon:100172854; -.
DR CTD; 51566; -.
DR eggNOG; ENOG502TCDI; Eukaryota.
DR GeneTree; ENSGT00940000162753; -.
DR HOGENOM; CLU_037187_0_0_1; -.
DR InParanoid; Q5R9J3; -.
DR OMA; DSKSIVW; -.
DR OrthoDB; 860703at2759; -.
DR TreeFam; TF335652; -.
DR Proteomes; UP000001595; Chromosome X.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019896; P:axonal transport of mitochondrion; IEA:Ensembl.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0008104; P:protein localization; IEA:Ensembl.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..379
FT /note="Armadillo repeat-containing X-linked protein 3"
FT /id="PRO_0000191367"
FT TOPO_DOM 1..6
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT TRANSMEM 7..29
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT REPEAT 111..151
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 153..192
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 233..272
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REGION 1..6
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305"
FT REGION 26..37
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305"
FT REGION 89..98
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT MOD_RES 61
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UH62"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UH62"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UH62"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UH62"
SQ SEQUENCE 379 AA; 42515 MW; 1815D937EDF4DB4C CRC64;
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGSGDVDDAG DCSGARYNDW
SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR ARRAVQKRAS PNSDDTILSP
QELQKVLCLV EMSEKPYILE AALIALGNNA AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK
EKALIVLNNL SVNAENQRRL KVYMNQVCDD TITSRLNSSV QLAGLRLLTN MTVTNEYQHM
LANSISDFFR LFSAGNEETK LQVLKLLLNL AENPAMTREL LRAQVPSSLG SLFNKKENKE
VILKLLVIFE NINDNFKWEE NEPTQNQFGE GSLFFFLKEF QVCADKVLGI ESHHDFLVKV
KVGKFMAKLA EHMFPKSQE
