ARMX3_RAT
ID ARMX3_RAT Reviewed; 379 AA.
AC Q5XID7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Armadillo repeat-containing X-linked protein 3;
GN Name=Armcx3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-67, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Regulates mitochondrial aggregation and transport in axons in
CC living neurons. May link mitochondria to the Trak2-kinesin motor
CC complex via its interaction with Miro and Trak2. Mitochondrial
CC distribution and dynamics is regulated through Armcx3 protein
CC degradation, which is promoted by PCK and negatively regulated by Wnt1.
CC Enhances the Sox10-mediated transactivation of the neuronal
CC acetylcholine receptor subunit alpha-3 and beta-4 subunit gene
CC promoters. {ECO:0000250|UniProtKB:Q8BHS6}.
CC -!- SUBUNIT: Interacts (via ARM domain) with MIRO1, MIRO2 and TRAK2. The
CC interaction with Miro is calcium-dependent. Interacts with Sox10.
CC {ECO:0000250|UniProtKB:Q8BHS6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q8BHS6}; Single-pass membrane protein
CC {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8BHS6}. Nucleus
CC {ECO:0000250|UniProtKB:Q8BHS6}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
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DR EMBL; BC083747; AAH83747.1; -; mRNA.
DR RefSeq; NP_001014295.1; NM_001014273.1.
DR AlphaFoldDB; Q5XID7; -.
DR SMR; Q5XID7; -.
DR BioGRID; 266720; 1.
DR STRING; 10116.ENSRNOP00000033859; -.
DR iPTMnet; Q5XID7; -.
DR PhosphoSitePlus; Q5XID7; -.
DR PaxDb; Q5XID7; -.
DR PRIDE; Q5XID7; -.
DR Ensembl; ENSRNOT00000029664; ENSRNOP00000033859; ENSRNOG00000025730.
DR Ensembl; ENSRNOT00000088760; ENSRNOP00000075527; ENSRNOG00000025730.
DR Ensembl; ENSRNOT00000114177; ENSRNOP00000086605; ENSRNOG00000025730.
DR Ensembl; ENSRNOT00000114255; ENSRNOP00000086584; ENSRNOG00000025730.
DR GeneID; 367902; -.
DR KEGG; rno:367902; -.
DR UCSC; RGD:1549739; rat.
DR CTD; 51566; -.
DR RGD; 1549739; Armcx3.
DR eggNOG; ENOG502TCDI; Eukaryota.
DR GeneTree; ENSGT00940000162753; -.
DR HOGENOM; CLU_037187_0_0_1; -.
DR InParanoid; Q5XID7; -.
DR OrthoDB; 860703at2759; -.
DR PhylomeDB; Q5XID7; -.
DR TreeFam; TF335652; -.
DR Reactome; R-RNO-9013404; RAC2 GTPase cycle.
DR PRO; PR:Q5XID7; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000025730; Expressed in cerebellum and 20 other tissues.
DR ExpressionAtlas; Q5XID7; baseline and differential.
DR Genevisible; Q5XID7; RN.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005829; C:cytosol; ISO:RGD.
DR GO; GO:0031307; C:integral component of mitochondrial outer membrane; ISO:RGD.
DR GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0019896; P:axonal transport of mitochondrion; ISO:RGD.
DR GO; GO:0007005; P:mitochondrion organization; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleus;
KW Phosphoprotein; Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..379
FT /note="Armadillo repeat-containing X-linked protein 3"
FT /id="PRO_0000191369"
FT TOPO_DOM 1..6
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT TRANSMEM 7..29
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..379
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT REPEAT 111..151
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 153..192
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 233..272
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REGION 1..6
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305"
FT REGION 26..37
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305"
FT REGION 34..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..98
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT MOD_RES 61
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 67
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UH62"
FT MOD_RES 110
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UH62"
SQ SEQUENCE 379 AA; 42553 MW; E4EA20CAAF376842 CRC64;
MGYARKVGWV TAGLVIGAGA CYCIYRLTRG RKQNKEKMAE GGPGDVEDAG DCSGARYNDW
SDDDDDSNES KSIVWYPPWA RIGTEAGTRA RARARARATR ARRAVQKRAS PNSDDTVLSP
QELQKVLCLV EMSEKPYILE AALIALGNNA AYAFNRDIIR DLGGLPIVAK ILNTRDPIVK
EKALIVLNNL SVNAENQRRL KIYMNQVCDD TVTSRLNSSV QLAGLRLLTN MTVTNEYQHI
LANSISDFFR LFSAGNEETK LQVLKLLLNL AENPAMTREL LGAHVPSSLG SLFNKKEYKE
VILKLLSIFE NINDNFKWEE NEPAQNHFSE GSLFFFLKEF QVCADKVLGI ESHHDFQVRV
KVGKFVTKLT ERMFPKSQE
