ARMX4_HUMAN
ID ARMX4_HUMAN Reviewed; 2290 AA.
AC Q5H9R4; A8K928; B3KXA4; F8W8Y7; Q5H9K8; Q8N8D6;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2019, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Armadillo repeat-containing X-linked protein 4;
GN Name=ARMCX4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP GLY-84.
RC TISSUE=Brain, Small intestine, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT GLY-84.
RC TISSUE=Fetal kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q5H9R4-2; Q86V38: ATN1; NbExp=3; IntAct=EBI-21899904, EBI-11954292;
CC Q5H9R4-2; Q92876: KLK6; NbExp=3; IntAct=EBI-21899904, EBI-2432309;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5H9R4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5H9R4-2; Sequence=VSP_060248, VSP_060250, VSP_060251;
CC Name=3;
CC IsoId=Q5H9R4-3; Sequence=VSP_060249, VSP_060250, VSP_060251;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform 3]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
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DR EMBL; AK096955; BAC04910.1; -; mRNA.
DR EMBL; AK126987; BAG54416.1; -; mRNA.
DR EMBL; AK292543; BAF85232.1; -; mRNA.
DR EMBL; CR933662; CAI45960.1; -; mRNA.
DR EMBL; AL035422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF459252; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z68873; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z69838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471115; EAX02869.1; -; Genomic_DNA.
DR CCDS; CCDS59170.1; -. [Q5H9R4-1]
DR RefSeq; NP_001243084.2; NM_001256155.2. [Q5H9R4-1]
DR AlphaFoldDB; Q5H9R4; -.
DR SMR; Q5H9R4; -.
DR IntAct; Q5H9R4; 3.
DR STRING; 9606.ENSP00000404304; -.
DR GlyGen; Q5H9R4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5H9R4; -.
DR PhosphoSitePlus; Q5H9R4; -.
DR BioMuta; ARMCX4; -.
DR DMDM; 84027758; -.
DR MassIVE; Q5H9R4; -.
DR PaxDb; Q5H9R4; -.
DR PeptideAtlas; Q5H9R4; -.
DR PRIDE; Q5H9R4; -.
DR ProteomicsDB; 30227; -.
DR ProteomicsDB; 62901; -. [Q5H9R4-1]
DR ProteomicsDB; 62902; -. [Q5H9R4-2]
DR Antibodypedia; 431; 52 antibodies from 10 providers.
DR DNASU; 100131755; -.
DR Ensembl; ENST00000423738.5; ENSP00000404304.3; ENSG00000196440.12. [Q5H9R4-1]
DR GeneID; 100131755; -.
DR KEGG; hsa:100131755; -.
DR MANE-Select; ENST00000423738.5; ENSP00000404304.3; NM_001256155.3; NP_001243084.2.
DR UCSC; uc065ahn.1; human. [Q5H9R4-1]
DR CTD; 100131755; -.
DR GeneCards; ARMCX4; -.
DR HGNC; HGNC:28615; ARMCX4.
DR HPA; ENSG00000196440; Low tissue specificity.
DR MIM; 301046; gene.
DR neXtProt; NX_Q5H9R4; -.
DR OpenTargets; ENSG00000196440; -.
DR VEuPathDB; HostDB:ENSG00000196440; -.
DR eggNOG; ENOG502SDV3; Eukaryota.
DR GeneTree; ENSGT00940000162587; -.
DR HOGENOM; CLU_065826_0_0_1; -.
DR InParanoid; Q5H9R4; -.
DR OMA; VYAKPEA; -.
DR OrthoDB; 860703at2759; -.
DR PhylomeDB; Q5H9R4; -.
DR TreeFam; TF335652; -.
DR PathwayCommons; Q5H9R4; -.
DR SignaLink; Q5H9R4; -.
DR BioGRID-ORCS; 100131755; 13 hits in 689 CRISPR screens.
DR ChiTaRS; ARMCX4; human.
DR GenomeRNAi; 100131755; -.
DR Pharos; Q5H9R4; Tdark.
DR PRO; PR:Q5H9R4; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5H9R4; protein.
DR Bgee; ENSG00000196440; Expressed in left ovary and 164 other tissues.
DR ExpressionAtlas; Q5H9R4; baseline and differential.
DR Genevisible; Q5H9R4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..2290
FT /note="Armadillo repeat-containing X-linked protein 4"
FT /id="PRO_0000191370"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 2031..2071
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 2073..2112
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 2153..2192
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 2194..2234
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REGION 517..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1302..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1521..1715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1911..1931
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1954..1973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1303..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1387..1402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1533..1560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1597..1611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1631..1648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1911..1930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MSAAGLKITGSKETKRRLLLISIDWVYCQEKQEERRELPRIITGPPP
FT EAAVVAFEWLKTSTLTGLHPQLPLSLPQPECALPYLVRAFSRGDYM (in isoform
FT 2)"
FT /id="VSP_060248"
FT VAR_SEQ 1
FT /note="M -> MSAAGLKITGSKETKRRLLLISIDWSRDLMNLCIYFRVYCQEKQEER
FT RELPRIITGPPPEAAVVAFEWLKTSTLTGLHPQLPLSLPQPECALPYLVRAFSRGDYM
FT (in isoform 3)"
FT /id="VSP_060249"
FT VAR_SEQ 244..256
FT /note="SVAKTQSEARPGA -> LIPRAFPSKNASC (in isoform 2 and
FT isoform 3)"
FT /id="VSP_060250"
FT VAR_SEQ 257..2290
FT /note="Missing (in isoform 2 and isoform 3)"
FT /id="VSP_060251"
FT VARIANT 84
FT /note="R -> G (in dbSNP:rs5951332)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_024761"
FT CONFLICT Q5H9R4-2:345
FT /note="N -> D (in Ref. 1; BAC04910)"
FT /evidence="ECO:0000305"
FT CONFLICT Q5H9R4-3:82
FT /note="P -> R (in Ref. 2; CAI45960)"
FT /evidence="ECO:0000305"
FT CONFLICT Q5H9R4-3:84
FT /note="S -> C (in Ref. 2; CAI45960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2290 AA; 235964 MW; 23A640FF02ABBF31 CRC64;
MGRIQEVGWV TAGLVIWAGT CYYIYKFTKG RAQSVRTLAR NGSTVKMETV VGVQSQTLAI
NEAEIKTKPQ VEIGAETGAR SGPRAEVETK ATAIAIHRAN SQAKAMVGAE PETQSESKVV
AGTLVMTEAV TLTEVKAKAR EVAMKEAVTQ TDAEAGKIVK KEAVTQTKAK AWALVAKTEA
KREAMTQTKA ETHILAEKET EINRVMVTQS ETLAVPREVA KMGATNKTGI VDETKTRALE
ETVSVAKTQS EARPGATVDA RGNPNGMSRE VAGVDMKSCA QSQAVTKIQG DDMPGTGVED
MGNCKTMSRA ESGADTRASA QPQIFAKTQT EAIPGAKIDA GGNTNAMCKV GAGADVRACI
QPQTVAKKQA EVTSGARVDG RGNTNVISKA ITGADMRAAA QPQAVASTHA EAMSDAKVKN
RGNPNAMTKA GAKANLRANS QVEALPDARD KSRGNPNVMA KVGDGTDMLS CTQPQLVASV
QADTLSDGKI KVRGNVNTMP KEGAGVDMKA QGMAQSQGEA LPNTRGKARG KAKAKCKTGP
GMDMKTCTQP QAGVKTPAEA LLDSRVDGRG NPNATSKAGT KADQRVCGQP LVVANPQGEA
LPGAKNKVKG NPHTVLKVGA GEGTTDSAQP EAVVSFQGEA LLGTKNKVKG NPNVVLKAEV
GEGAMGTAQL QIMASSKGEA LLDSKNKVKG NSNAVSKAGA GTDTTGSVQP QIVANSQGEV
LPGAKNKIRG NPTTVPNSGV GPYTTDSARL QAVANSQGEV LPGAKNKVKA NLNAVSKAEA
GMGATGSVQP QAVANSHCET LPGAKNKVRG NWNAVSKAGA GMDTRGSAQP QAVANSQGEV
LPGAKNKVKG NPNVVSKAGA REDTVGSTQP QVLASSQRET LPGARNKVKG NSNVVSKAGA
REDTMGSAQP QVVANSQRET LPGARNKVKG NSNAISKAEA GAGIMGSVQV QVVASFQGEV
LPGAKNKVRG NSNAVPKAEA GADTVGSAQP QAVANSQSET LLGARNKVKG NTIAVPKAGT
GAGTRHSAQP QIVAGSQGET LPGARDKSMS TSEAEATAED EAYAKPEAEA MPTSESEGGS
GTQACRKTQP NIHDYYWNGI GVEDWIAAER WIKFRFQTMD GDWENSVSWA DDENEASIGS
WSGASDKAGI IRSWAVACDE TSVKSWAGAR AENVVGIGTW ARAGEQASGG LWAGGQTSEG
TWAGDKASGG AWTGAENQAS GGSWALAGNQ AIGELWAAGQ ASDGSWPGGQ ASGVSWVGEE
AIGGSWTGAE NQASEGSWAG AGAGNMSSVS YWAGVVDQAG GGSWAGTSDQ SGGGSKPRFE
DQASGEGSWA GAGGQASGGS MLGPEDQSSG RSWADTADQA SGGSRLGHVD QSSGGAWAGT
LDQSGGGSKP RFENQTTEEG SWAGAGGQAG GGSKVGPEDQ SSGRSWANSG DQISGGFLVG
IVDQANGGSW TGAGHPASVG PKPIFEDQVS GRGSWADARE QVVGDSRLGL RDQSSGDSWA
GTGDQASGWF CVCPGSQTNG GSWGGASGQD VGGSRPGPTN QSSAGSWDSP GSQVSGSCWT
GAGAVDQAGG CSKPGFEDQA IGGGFWPGAG DQTGGGSRPG SEDQSSGIGS WGVAGGQVLG
GARPGPADQS SGGSWAGTGN QSSGRSWIGP GDQAVDCSKP EFEDQACGGG SWAGAGSQAS
GESWAGSRPG NEAIGGSRMG SEDQATGGSW ARSEDQASGR FQVSFEVEAN EGFWFGPGAE
AVIGSWCWTE EKADIVSRPD DKDEATTASR SGAGEEAMIC SRIEAENKAS SGSWIRSEEV
AYMGSCVGAE AGAGAEAGAG AEAGAGAGAE AGAEAGAGAG AGPGTESGAG IWSWDGDATT
VESRLGAGEE AGVESWTLAR NVGEDELSRE SSPDIEEISL RSLFWAESEN SNTFRSKSGK
DASFESGAGD NTSIKDKFEA AGGVDIGSWF CAGNENTSED KSAPKAKAKK SSESRGIYPY
MVPGAGMGSW DGAMIWSETK FAHQSEASFP VEDESRKQTR TGEKTRPWSC RCKHEANMDP
RDLEKLICMI EMTEDPSVHE IANNALYNSA DYSYSHEVVR NVGGISVIES LLNNPYPSVR
QKALNALNNI SVAAENHRKV KTYLNQVCED TVTYPLNSNV QLAGLRLIRH LTITSEYQHM
VTNYISEFLR LLTVGSGETK DHVLGMLLNF SKNPSMTKDL LIANAPTSLI NIFSKKETKE
NILNALSLFE NINYHFKRRA KAFTQDKFSK NSLYFLFQRP KACAKKLRAL AAECNDPEVK
ERVELLISKL
