ARMX5_MOUSE
ID ARMX5_MOUSE Reviewed; 606 AA.
AC Q3UZB0; A2AGB5;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Armadillo repeat-containing X-linked protein 5;
GN Name=Armcx5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=22569362; DOI=10.1038/ncomms1829;
RA Lopez-Domenech G., Serrat R., Mirra S., D'Aniello S., Somorjai I., Abad A.,
RA Vitureira N., Garcia-Arumi E., Alonso M.T., Rodriguez-Prados M.,
RA Burgaya F., Andreu A.L., Garcia-Sancho J., Trullas R., Garcia-Fernandez J.,
RA Soriano E.;
RT "The eutherian Armcx genes regulate mitochondrial trafficking in neurons
RT and interact with Miro and Trak2.";
RL Nat. Commun. 3:814-814(2012).
CC -!- TISSUE SPECIFICITY: Highly expressed in the developing neural tissues,
CC neural crest derivatives and hind limbs. {ECO:0000269|PubMed:22569362}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
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DR EMBL; AK133950; BAE21947.1; -; mRNA.
DR EMBL; AL683822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30408.1; -.
DR RefSeq; NP_001009575.2; NM_001009575.5.
DR AlphaFoldDB; Q3UZB0; -.
DR SMR; Q3UZB0; -.
DR BioGRID; 243463; 1.
DR IntAct; Q3UZB0; 1.
DR STRING; 10090.ENSMUSP00000094045; -.
DR iPTMnet; Q3UZB0; -.
DR PhosphoSitePlus; Q3UZB0; -.
DR MaxQB; Q3UZB0; -.
DR PaxDb; Q3UZB0; -.
DR PRIDE; Q3UZB0; -.
DR ProteomicsDB; 283272; -.
DR Antibodypedia; 384; 45 antibodies from 14 providers.
DR DNASU; 494468; -.
DR Ensembl; ENSMUST00000096321; ENSMUSP00000094045; ENSMUSG00000072969.
DR GeneID; 494468; -.
DR KEGG; mmu:494468; -.
DR UCSC; uc009uhk.1; mouse.
DR CTD; 64860; -.
DR MGI; MGI:2148026; Armcx5.
DR VEuPathDB; HostDB:ENSMUSG00000072969; -.
DR eggNOG; ENOG502RK9I; Eukaryota.
DR GeneTree; ENSGT00940000163081; -.
DR HOGENOM; CLU_037187_2_0_1; -.
DR InParanoid; Q3UZB0; -.
DR OMA; PKACRCK; -.
DR OrthoDB; 860703at2759; -.
DR PhylomeDB; Q3UZB0; -.
DR TreeFam; TF335652; -.
DR BioGRID-ORCS; 494468; 3 hits in 71 CRISPR screens.
DR PRO; PR:Q3UZB0; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q3UZB0; protein.
DR Bgee; ENSMUSG00000072969; Expressed in animal zygote and 70 other tissues.
DR Genevisible; Q3UZB0; MM.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat.
FT CHAIN 1..606
FT /note="Armadillo repeat-containing X-linked protein 5"
FT /id="PRO_0000191373"
FT REPEAT 349..388
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 470..509
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 511..551
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 568..606
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 67895 MW; 4E48CBF48402219C CRC64;
MIGSKTKRKA REESGASSKP GTNSPANAKG KAKNQTTKAV KAEPKEEWGN QAEARDEAVA
RTQPAISTEP KTVTWKVKKK KDKTNARVMA QAKTELPAGP ALVPHTKSDA LPTSVVITVT
KSEVKIDTGI EASLKGAAKA TDKRSIKQKP EIKKEVCVKS RAGDKAKEVC VKSSAGDKAK
EVCVKSRAGD KAKEVCVKSR AGDKASIVIN TTDEDEDYVC SWFWTGEEPS VGSWFWPKEE
NPLQVYQPPP KVEEEPEPPD TFDYALKKKA AAWLRGRFIV LVPIEEPQPS LPPDGNWTLV
ATLIETPLGI RPLTKIPPYG GPYFQTLADL KNQIREKEKY GPNPNTCRCK SRTFSLEPVD
FDKLVALLKL TRDPFIHEIA TMIMGISPAY PFTQDIVHDV GITVMIENFV NNPNAKKYPR
TLNINANPDA PEEVKETEAH VNKVCRDILC CPLNCSVQVE ELKLLVSLSV KFDYHHVVIY
YVRYFISLLN KGSVKIKFQI LRVLLCLSKN QANTRELISA EVMSSLVALF HKNESKANIL
HIIEIFENIN FQFKKRAKLF TKEMFTKSEL ISIFREAKEF DQKLQDLTDH SDPDVRDKVI
RLILKL
