ARMX6_MOUSE
ID ARMX6_MOUSE Reviewed; 301 AA.
AC Q8K3A6; A2AKS3; Q3TUH4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein ARMCX6;
GN Name=Armcx6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-133.
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=22569362; DOI=10.1038/ncomms1829;
RA Lopez-Domenech G., Serrat R., Mirra S., D'Aniello S., Somorjai I., Abad A.,
RA Vitureira N., Garcia-Arumi E., Alonso M.T., Rodriguez-Prados M.,
RA Burgaya F., Andreu A.L., Garcia-Sancho J., Trullas R., Garcia-Fernandez J.,
RA Soriano E.;
RT "The eutherian Armcx genes regulate mitochondrial trafficking in neurons
RT and interact with Miro and Trak2.";
RL Nat. Commun. 3:814-814(2012).
CC -!- FUNCTION: May regulate the dynamics and distribution of mitochondria in
CC neural cells. {ECO:0000269|PubMed:22569362}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22569362}.
CC Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8BHS6}; Single-
CC pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the developing neural tissues,
CC neural crest derivatives and hind limbs. Also widely expressed in the
CC adult nervous tissue, especially in the forebrain, including the
CC cerebral cortex, hippocampus and thalamus.
CC {ECO:0000269|PubMed:22569362}.
CC -!- SIMILARITY: Belongs to the eutherian X-chromosome-specific Armcx
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL772348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC027264; AAH27264.1; -; mRNA.
DR EMBL; AK160766; BAE35997.1; -; mRNA.
DR CCDS; CCDS30399.1; -.
DR RefSeq; NP_001007579.1; NM_001007578.2.
DR RefSeq; XP_011246047.1; XM_011247745.2.
DR RefSeq; XP_011246048.1; XM_011247746.2.
DR AlphaFoldDB; Q8K3A6; -.
DR SMR; Q8K3A6; -.
DR STRING; 10090.ENSMUSP00000057277; -.
DR PhosphoSitePlus; Q8K3A6; -.
DR PaxDb; Q8K3A6; -.
DR PRIDE; Q8K3A6; -.
DR Antibodypedia; 14751; 117 antibodies from 20 providers.
DR DNASU; 278097; -.
DR Ensembl; ENSMUST00000052431; ENSMUSP00000057277; ENSMUSG00000050394.
DR Ensembl; ENSMUST00000113194; ENSMUSP00000108819; ENSMUSG00000050394.
DR GeneID; 278097; -.
DR KEGG; mmu:278097; -.
DR UCSC; uc012hom.1; mouse.
DR CTD; 54470; -.
DR MGI; MGI:2147993; Armcx6.
DR VEuPathDB; HostDB:ENSMUSG00000050394; -.
DR eggNOG; ENOG502RP3G; Eukaryota.
DR GeneTree; ENSGT00940000163042; -.
DR HOGENOM; CLU_037187_0_1_1; -.
DR InParanoid; Q8K3A6; -.
DR OMA; FIQGKMW; -.
DR OrthoDB; 949439at2759; -.
DR PhylomeDB; Q8K3A6; -.
DR TreeFam; TF335652; -.
DR BioGRID-ORCS; 278097; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Armcx6; mouse.
DR PRO; PR:Q8K3A6; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q8K3A6; protein.
DR Bgee; ENSMUSG00000050394; Expressed in ovary and 57 other tissues.
DR Genevisible; Q8K3A6; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR InterPro; IPR006911; ARM-rpt_dom.
DR Pfam; PF04826; Arm_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..301
FT /note="Protein ARMCX6"
FT /id="PRO_0000191375"
FT TOPO_DOM 1..7
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT TRANSMEM 8..25
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q8BHS6"
FT REGION 1..6
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305|PubMed:22569362"
FT REGION 26..36
FT /note="Mitochondrion outer membrane (MOM)-targeting
FT sequence"
FT /evidence="ECO:0000305|PubMed:22569362"
FT REGION 69..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 301 AA; 33321 MW; 0F031AE73BA9330A CRC64;
MGRAREMGWM AAGLMIGAGA CYCMYKLTMG RSEGNELEDE EEDEWEDGQD LDEEEADNWF
DFTAMARPWS EDGDWDEPGA PGGTEDRRSG GGKANRAHPI KQRPFPYEHK NIWGEQSFKS
FTCILDLNKC VSTQRKKRFT KNINAGFSLS PNISKHLASL SVVGNRSPTP HPTVREKALF
VPENPNSSLE NQGQIKMSID EVCRETLLCC CKSFLQQAGL SLLISMTVIN NMLAKSVSDL
KFPLLSKGSG CAEVRGLEEL MSLSEKPVLV GEALAAQMLS SFMCLFTRSG SREMLVEAIS
P
