ARM_AEDAE
ID ARM_AEDAE Reviewed; 832 AA.
AC Q17GS9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Armadillo segment polarity protein;
GN Name=arm {ECO:0000250|UniProtKB:P18824}; ORFNames=AAEL002887;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1] {ECO:0000312|EMBL:EAT45858.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: May associate with CadN and participate in the transmission
CC of developmental information. Can associate with alpha-catenin.
CC Accumulates through wg signaling; arm function in wg signal
CC transduction is required early in development for determination of
CC neuroblast fate. Arm and Abl proteins function cooperatively at
CC adherens junctions in both the CNS and epidermis (By similarity).
CC {ECO:0000250|UniProtKB:P18824}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P18824}. Cell
CC membrane {ECO:0000250|UniProtKB:P18824}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P18824}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P18824}. Cell junction, adherens junction
CC {ECO:0000250|UniProtKB:P18824}. Note=Inner surface of cell membrane and
CC adherens junction. {ECO:0000250|UniProtKB:P18824}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000255}.
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DR EMBL; CH477256; EAT45858.1; -; Genomic_DNA.
DR RefSeq; XP_001662670.1; XM_001662620.1.
DR AlphaFoldDB; Q17GS9; -.
DR SMR; Q17GS9; -.
DR STRING; 7159.AAEL002887-PA; -.
DR PRIDE; Q17GS9; -.
DR GeneID; 5576477; -.
DR KEGG; aag:5576477; -.
DR VEuPathDB; VectorBase:AAEL002887; -.
DR eggNOG; KOG4203; Eukaryota.
DR HOGENOM; CLU_008757_1_1_1; -.
DR InParanoid; Q17GS9; -.
DR OMA; KNEAHQR; -.
DR OrthoDB; 321213at2759; -.
DR PhylomeDB; Q17GS9; -.
DR Proteomes; UP000008820; Chromosome 1.
DR GO; GO:0005912; C:adherens junction; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045296; F:cadherin binding; ISS:UniProtKB.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0014017; P:neuroblast fate commitment; ISS:UniProtKB.
DR GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013284; Beta-catenin.
DR PANTHER; PTHR45976; PTHR45976; 1.
DR Pfam; PF00514; Arm; 4.
DR PRINTS; PR01869; BCATNINFAMLY.
DR SMART; SM00185; ARM; 11.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 9.
PE 3: Inferred from homology;
KW Cell adhesion; Cell junction; Cell membrane; Cytoplasm;
KW Developmental protein; Membrane; Reference proteome; Repeat;
KW Segmentation polarity protein; Wnt signaling pathway.
FT CHAIN 1..832
FT /note="Armadillo segment polarity protein"
FT /id="PRO_0000312833"
FT REPEAT 146..185
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 188..228
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 230..269
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 272..311
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 356..395
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 397..434
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 483..524
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 594..634
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REPEAT 636..675
FT /note="ARM 9"
FT /evidence="ECO:0000255"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..783
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 90307 MW; 6331B575249EE484 CRC64;
MSYQMPQNRT MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT QVPSLSGKDD
DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR AAMFPETLEE GIEIPSTQFD
PQQPTAVQRL SEPSQMLKHA VVNLINYQDD ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV
HQLSKKEASR HAIMNSPQMV AALVRALSQS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG
GIPALVKLLS SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK VLSVCSSNKP
AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV DGLETLLSGL VTVLGSSDVN
VVTCAAGILS NLTCNNQRNK VTVCQVGGVE ALVGTIINAG DREEITEPAV CALRHLTSRH
PESESAQNIV RNGYGLPVIV KLLNPPSRWP LIKAVIGLIR NLALCPSNAA PLREHGAIHL
LVRLLFKAFQ DTQRQRSSVA TNGSQPPGAY ADGVRMEEIV EGTVGALHIL SKEELNRQLI
RQQNVISIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP LTELLNSANE
GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDTM WNNGELGIGP DLQDILSPDQ
AYEGLYGQGP PSVHSSHGGR AFQQGYDTLP IDSMQGLEIG GGGNAGPAGS NPNAGNNPGA
GGPPSGQPTS PYAMDMDVGE MDASELTFDH LDVMPSPPQD NNQVAAWYDT DL
