ARM_ANOGA
ID ARM_ANOGA Reviewed; 850 AA.
AC Q7QHW5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 5.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Armadillo segment polarity protein;
GN Name=arm; ORFNames=AGAP001043;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: May associate with CadN and participate in the transmission
CC of developmental information. Can associate with alpha-catenin.
CC Accumulates through wg signaling; arm function in wg signal
CC transduction is required early in development for determination of
CC neuroblast fate. Arm and Abl proteins function cooperatively at
CC adherens junctions in both the CNS and epidermis (By similarity).
CC {ECO:0000250|UniProtKB:P18824}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}.
CC Note=Inner surface of cell membrane and adherens junction.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000255}.
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DR EMBL; AAAB01008811; EAA04913.5; -; Genomic_DNA.
DR RefSeq; XP_309245.5; XM_309245.5.
DR AlphaFoldDB; Q7QHW5; -.
DR SMR; Q7QHW5; -.
DR STRING; 7165.AGAP001043-PA; -.
DR PaxDb; Q7QHW5; -.
DR PRIDE; Q7QHW5; -.
DR GeneID; 1270538; -.
DR KEGG; aga:AgaP_AGAP001043; -.
DR CTD; 1270538; -.
DR VEuPathDB; VectorBase:AGAP001043; -.
DR eggNOG; KOG4203; Eukaryota.
DR HOGENOM; CLU_008757_1_1_1; -.
DR InParanoid; Q7QHW5; -.
DR OMA; KNEAHQR; -.
DR OrthoDB; 321213at2759; -.
DR PhylomeDB; Q7QHW5; -.
DR Proteomes; UP000007062; Chromosome X.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045294; F:alpha-catenin binding; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IBA:GO_Central.
DR GO; GO:0019903; F:protein phosphatase binding; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013284; Beta-catenin.
DR PANTHER; PTHR45976; PTHR45976; 1.
DR Pfam; PF00514; Arm; 4.
DR PRINTS; PR01869; BCATNINFAMLY.
DR SMART; SM00185; ARM; 11.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 9.
PE 3: Inferred from homology;
KW Cell adhesion; Cell junction; Cell membrane; Cytoplasm;
KW Developmental protein; Membrane; Reference proteome; Repeat;
KW Segmentation polarity protein; Wnt signaling pathway.
FT CHAIN 1..850
FT /note="Armadillo segment polarity protein"
FT /id="PRO_0000064291"
FT REPEAT 146..185
FT /note="ARM 1"
FT REPEAT 188..228
FT /note="ARM 2"
FT REPEAT 230..269
FT /note="ARM 3"
FT REPEAT 272..311
FT /note="ARM 4"
FT REPEAT 356..395
FT /note="ARM 5"
FT REPEAT 397..434
FT /note="ARM 6"
FT REPEAT 483..524
FT /note="ARM 7"
FT REPEAT 594..634
FT /note="ARM 8"
FT REPEAT 636..675
FT /note="ARM 9"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 756..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 766..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 850 AA; 91665 MW; 44233E955FCB41CB CRC64;
MSYQMPQNRS MSHNPYNSSD MPMPSAKEQT LMWQQNSYLG DSGIHSGAVT QVPSLSGKDD
DMEDDPLMFD MDQGFSQNFT QDQVDDMNQQ LSQTRSQRVR AAMFPETLEE GIEIPSTQFD
PQQPTAVQRL AEPSQMLKHA VVNLINYQDD ADLATRAIPE LIKLLNDEDQ VVVSQAAMMV
HQLSKKEASR HAIMNSPQMV AALVRALSNS NDLETTKGAV GTLHNLSHHR QGLLAIFKSG
GIPALVKLLS SPVESVLFYA ITTLHNLLLH QDGSKMAVRL AGGLQKMVAL LQRNNVKFLA
IVTDCLQILA YGNQESKLII LASTGPSELV RIMRSYDYEK LLWTTSRVLK VLSVCSSNKP
AIVEAGGMQA LAMHLGNPSQ RLVQNCLWTL RNLSDAATKV DGLETLLSGL VTVLGSSDVN
VVTCAAGILS NLTCNNQRNK VTVCQVGGVE ALVGTIINAG DREEITEPAV CALRHLTSRH
PESESAQNVV RNGYGLPVIV KLLNPPSRWP LIKAVIGLIR NLALCPANAA PLREHGAIHL
LVRLLFKAFQ DTQRQRSSVA SNGSQPPGAY ADGVRMEEIV EGTVGALHIL AKEEYNRQVI
RSQNVIPIFV QLLFYNDIEN IQRVAAGVLC ELAVDKEVAE MIEAEGATAP LTELLNSANE
GVATYAAAVL FKMSEDKSMD YKKRFSSELT TLPVFRDDSM WNNGELGIGP DLQDILSPEQ
AYEGLYGQGP ASVHSSHGGR AFQQGYDTLP IDSMQGLEIG GGGGSSNGGA TGNGGMGGQQ
QQSGGGPGSV VMGGGGASGM SSSGQPTSPY GMDMDVGEME ASELTFDHLD VMPSPPQDNN
QVAAWYDTDL
