ARM_DROPS
ID ARM_DROPS Reviewed; 832 AA.
AC Q29I35; B5DLU2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 2.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Armadillo segment polarity protein;
GN Name=arm {ECO:0000250|UniProtKB:P18824}; ORFNames=GA27602;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: May associate with CadN and participate in the transmission
CC of developmental information. Can associate with alpha-catenin.
CC Accumulates through wg signaling; arm function in wg signal
CC transduction is required early in development for determination of
CC neuroblast fate. Arm and Abl proteins function cooperatively at
CC adherens junctions in both the CNS and epidermis (By similarity).
CC {ECO:0000250|UniProtKB:P18824}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P18824}. Cell
CC membrane {ECO:0000250|UniProtKB:P18824}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P18824}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P18824}. Cell junction, adherens junction
CC {ECO:0000250|UniProtKB:P18824}. Note=Inner surface of cell membrane and
CC adherens junction. {ECO:0000250|UniProtKB:P18824}.
CC -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDY72488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH379064; EDY72488.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q29I35; -.
DR SMR; Q29I35; -.
DR STRING; 7237.FBpp0285007; -.
DR eggNOG; KOG4203; Eukaryota.
DR InParanoid; Q29I35; -.
DR ChiTaRS; arm; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005912; C:adherens junction; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045296; F:cadherin binding; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0014017; P:neuroblast fate commitment; ISS:UniProtKB.
DR GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR013284; Beta-catenin.
DR PANTHER; PTHR45976; PTHR45976; 1.
DR Pfam; PF00514; Arm; 4.
DR PRINTS; PR01869; BCATNINFAMLY.
DR SMART; SM00185; ARM; 12.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 9.
PE 3: Inferred from homology;
KW Cell adhesion; Cell junction; Cell membrane; Cytoplasm;
KW Developmental protein; Membrane; Reference proteome; Repeat;
KW Segmentation polarity protein; Wnt signaling pathway.
FT CHAIN 1..832
FT /note="Armadillo segment polarity protein"
FT /id="PRO_0000312834"
FT REPEAT 149..188
FT /note="ARM 1"
FT REPEAT 191..231
FT /note="ARM 2"
FT REPEAT 233..272
FT /note="ARM 3"
FT REPEAT 275..314
FT /note="ARM 4"
FT REPEAT 359..397
FT /note="ARM 5"
FT REPEAT 398..437
FT /note="ARM 6"
FT REPEAT 440..481
FT /note="ARM 7"
FT REPEAT 487..527
FT /note="ARM 8"
FT REPEAT 597..636
FT /note="ARM 9"
FT REPEAT 638..677
FT /note="ARM 10"
FT REGION 765..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 832 AA; 90293 MW; 52205E16C85BE598 CRC64;
MSYMPAQNRT MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LGDSGIHSGA VTQVPSLSGK
EDEEMEGDPL MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET LEEGIEIPST
QFDPQQPTAV QRLSEPSQML KHAVVNLINY QDDAELATRA IPELIKLLND EDQVVVSQAA
MMVHQLSKKE ASRHAIMNSP QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF
KSGGIPALVK LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK
FLAIVTDCLQ ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS
NKPAIVDAGG MQALAMHLGN MSPRLVQNCL WTLRNLSDAA TKVEGLEALL QSLVQVLGST
DVNVVTCAAG ILSNLTCNNQ RNKATVCQVG GVDALVRTII NAGDREEITE PAVCALRHLT
SRHVDSELAQ NAVRLNYGLS VIVKLLHPPS RWPLIKAVIG LIRNLALCPA NHAPLREHGA
IHHLVRLLMR AFQDTERQRS SIATTGSQQP SAYADGVRME EIVEGTVGAL HILARESHNR
ALIRQQSVIP IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR
NEGVATYAAA VLFRMSEDKP QDYKKRLSIE LTNSLLREDN NIWANADLGM GPDLQVGSLQ
GASALILLLY IFSISPYRLF AGYDTLPIDS MQGLEISSPV GGGGATGNSG GVNSASAGSG
AVVPPSGAPT SPYSMDMDVG EIDAGALNFD LDAMPTPPND NNNLAAWYDT DC
