ID   ARM_MUSDO               Reviewed;         813 AA.
AC   Q02453;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Armadillo segment polarity protein;
GN   Name=arm;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DISRUPTION PHENOTYPE.
RX   PubMed=8483160; DOI=10.1007/bf00160477;
RA   Peifer M.A., Wieschaus E.;
RT   "The product of the Drosophila melanogaster segment polarity gene armadillo
RT   is highly conserved in sequence and expression in the housefly Musca
RT   domestica.";
RL   J. Mol. Evol. 36:224-233(1993).
CC   -!- FUNCTION: May associate with CadN and participate in the transmission
CC       of developmental information. Can associate with alpha-catenin.
CC       Accumulates through wg signaling; arm function in wg signal
CC       transduction is required early in development for determination of
CC       neuroblast fate. Arm and Abl proteins function cooperatively at
CC       adherens junctions in both the CNS and epidermis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with Mer and Moe at the adherens junction.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}.
CC       Note=Inner surface of cell membrane and adherens junction.
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated on Ser, Thr and Tyr residues. Level of
CC       phosphorylation varies both during embryonic development and from
CC       embryonic tissue to tissue. Sgg is required for phosphorylation and wg
CC       signal negatively regulates arm phosphorylation. Hypophosphorylated
CC       form of arm increases in steady-state levels (By similarity).
CC       {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Development of anterior structures in the
CC       posterior part of the segment. {ECO:0000269|PubMed:8483160}.
CC   -!- SIMILARITY: Belongs to the beta-catenin family. {ECO:0000305}.
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DR   EMBL; L04874; AAA29292.1; -; mRNA.
DR   RefSeq; NP_001273824.1; NM_001286895.1.
DR   AlphaFoldDB; Q02453; -.
DR   SMR; Q02453; -.
DR   STRING; 7370.XP_005180917.1; -.
DR   PRIDE; Q02453; -.
DR   GeneID; 101899911; -.
DR   KEGG; mde:101899911; -.
DR   CTD; 101899911; -.
DR   VEuPathDB; VectorBase:MDOA012332; -.
DR   eggNOG; KOG4203; Eukaryota.
DR   Proteomes; UP000095301; Unplaced.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR013284; Beta-catenin.
DR   PANTHER; PTHR45976; PTHR45976; 1.
DR   Pfam; PF00514; Arm; 4.
DR   PRINTS; PR01869; BCATNINFAMLY.
DR   SMART; SM00185; ARM; 12.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 9.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Cell junction; Cell membrane; Cytoplasm;
KW   Developmental protein; Membrane; Phosphoprotein; Repeat;
KW   Segmentation polarity protein; Wnt signaling pathway.
FT   CHAIN           1..813
FT                   /note="Armadillo segment polarity protein"
FT                   /id="PRO_0000064293"
FT   REPEAT          139..178
FT                   /note="ARM 1"
FT   REPEAT          180..221
FT                   /note="ARM 2"
FT   REPEAT          223..262
FT                   /note="ARM 3"
FT   REPEAT          265..304
FT                   /note="ARM 4"
FT   REPEAT          349..387
FT                   /note="ARM 5"
FT   REPEAT          388..427
FT                   /note="ARM 6"
FT   REPEAT          430..471
FT                   /note="ARM 7"
FT   REPEAT          477..517
FT                   /note="ARM 8"
FT   REPEAT          587..626
FT                   /note="ARM 9"
FT   REPEAT          628..667
FT                   /note="ARM 10"
FT   REGION          714..779
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   813 AA;  88237 MW;  73E61F59BDBFA580 CRC64;
     MSHNNQYNPP DLPPMVSAKE QTLMWQQNSY LVDSGIHSGA VTQAPSLSGK EDEEMEGDPL
     MFDLDTGFPQ NFTQDQVDDM NQQLSQTRSQ RVRAAMFPET LEEGIEIPST QFDPQQPTAV
     QRLAEPSQML KHAVVNLINY QDDAELATRA IPELIKLLND EDQVVVSQAA MMVHQLSKKE
     ASRHAITNSP QMVAALVRAI SNSNDLESTK AAVGTLHNLS HHRQGLLAIF KSGGIPALVK
     LLSSPVESVL FYAITTLHNL LLHQDGSKMA VRLAGGLQKM VTLLQRNNVK FLAIVTDCLQ
     ILAYGNQESK LIILASGGPN ELVRIMRSYD YEKLLWTTSR VLKVLSVCSS NKPAIVDAGG
     MQALAMHLSN PSPRLVQNCL WTLRNLSDAA TKVDGLEPLL QSLVQVLAST DVNVVTCAAG
     ILSNLTCNNQ RNKATVCQVG GVDALVRTII NAGDREEITE PAVCALRHLT TRHADSEMAQ
     NAVRLNYGLS VIVKLLHPPS RWPLIKAAIG LVRNLALCPA NAAPLREHGA IHHLVRLLMR
     AFQDTERQRS SVATTGSQQP AAYADGVRME EIVEGTVGAL HILARESHNR ALIRQQSVIP
     IFVRLLFNEI ENIQRVAAGV LCELAADKEG AEIIEQEGAT GPLTDLLHSR NEGVATYAAA
     VLFRMSEDKP QDYKKRLSIE LTTNSLLRED NNIWGNADLG LGPDLQDMLG PEQAYEGLYG
     QGPPSVHSSH GGRAFQQGYD TLPIDSMQGL EISSPVGGGG GGGAPPSAAP TSPYSMDMDV
     GEIDAGALNF DLDAMPTPPN DNNNLAAWYD TDC