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ARN2_YEAST
ID   ARN2_YEAST              Reviewed;         620 AA.
AC   P38724; D3DKS4;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 163.
DE   RecName: Full=Siderophore iron transporter ARN2;
DE   AltName: Full=Triacetylfusarinine C permease;
DE   AltName: Full=Triacetylfusarinine C transporter 1;
GN   Name=ARN2; Synonyms=TAF1; OrderedLocusNames=YHL047C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 619.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=10816729; DOI=10.1023/a:1009252118050;
RA   Heymann P., Ernst J.F., Winkelmann G.;
RT   "Identification of a fungal triacetylfusarinine C siderophore transport
RT   gene (TAF1) in Saccharomyces cerevisiae as a member of the major
RT   facilitator superfamily.";
RL   BioMetals 12:301-306(1999).
RN   [4]
RP   FUNCTION.
RX   PubMed=10744769; DOI=10.1074/jbc.275.14.10709;
RA   Yun C.-W., Ferea T., Rashford J., Ardon O., Brown P.O., Botstein D.,
RA   Kaplan J., Philpott C.C.;
RT   "Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence
RT   for two pathways of iron uptake.";
RL   J. Biol. Chem. 275:10709-10715(2000).
CC   -!- FUNCTION: Involved in the transport of siderophore triacestylfusarinine
CC       C and so has a role in iron homeostasis. {ECO:0000269|PubMed:10744769,
CC       ECO:0000269|PubMed:10816729}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB65059.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; U11583; AAB65059.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; BK006934; DAA06641.2; -; Genomic_DNA.
DR   PIR; S48921; S48921.
DR   RefSeq; NP_011816.2; NM_001179127.2.
DR   AlphaFoldDB; P38724; -.
DR   BioGRID; 36378; 23.
DR   DIP; DIP-7479N; -.
DR   STRING; 4932.YHL047C; -.
DR   TCDB; 2.A.1.16.3; the major facilitator superfamily (mfs).
DR   PaxDb; P38724; -.
DR   PRIDE; P38724; -.
DR   EnsemblFungi; YHL047C_mRNA; YHL047C; YHL047C.
DR   GeneID; 856338; -.
DR   KEGG; sce:YHL047C; -.
DR   SGD; S000001039; ARN2.
DR   VEuPathDB; FungiDB:YHL047C; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   GeneTree; ENSGT00940000176305; -.
DR   HOGENOM; CLU_012970_2_1_1; -.
DR   InParanoid; P38724; -.
DR   OMA; SIGMWAF; -.
DR   BioCyc; YEAST:G3O-31063-MON; -.
DR   PRO; PR:P38724; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38724; protein.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR   GO; GO:0015343; F:siderophore transmembrane transporter activity; IDA:SGD.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IMP:SGD.
DR   GO; GO:0009237; P:siderophore metabolic process; IMP:SGD.
DR   GO; GO:0015891; P:siderophore transport; IDA:SGD.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Endosome; Ion transport; Iron; Iron transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..620
FT                   /note="Siderophore iron transporter ARN2"
FT                   /id="PRO_0000084863"
FT   TRANSMEM        71..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        491..513
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        561..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   620 AA;  69566 MW;  19C3DDF83A1FC760 CRC64;
     MIEVPEDNRS SQTKRKNTEK NCNELMVDEK MDDDSSPRDE MKDKLKGTKS LIIRKSELMA
     KKYDTWQLKA IFLFSAFICT FAYGLDSSIR GTYMTYAMNS YSAHSLISTV SVIVLMISAV
     SQVIFGGLSD IFGRLTLFLV SIVLYIVGTI IQSQAYDVQR YAAGAVFYYV GLVGVMLQVV
     LMLSDNSSLK WRLFYTLIPS WPSIITTWVS GSVVEAANPL ENWSWNIAMW AFIFPLCCIP
     LILCMLHMRW KVRNDVEWKE LQDEKSYYQT HGLVQMLVQL FWKLDVVGVL LFTAGVGCIL
     VPLTLAGGVS TNWRNSKIIG PFVLGFVLVP GFIYWESRLA LVPFAPFKLL KDRGVWAPLG
     IMFFICFVYQ MAAGYLYTIL VVAVDESASS ATRIINLYSF VTAVVAPFLG LIVTRSSRLK
     SYIIFGGSLY FITMGLFYRY RSGQDADGGI IAGMVIWGLS SCLFDYPTIV SIQSVTSHEN
     MATVTALNYT VFRIGGAVAA AISGAIWTQS LYPKLLHYMG DADLATAAYG SPLTFILSNP
     WGTPVRSAMV EAYRHVQKYE VIVALVFSAP MFLLTFCVRD PRLTEDFAQK LPDREYVQTK
     EDDPINDWIA KRFAKALGRS
 
 
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