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MNMG_OPITP
ID   MNMG_OPITP              Reviewed;         634 AA.
AC   B1ZWP4;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG {ECO:0000255|HAMAP-Rule:MF_00129};
DE   AltName: Full=Glucose-inhibited division protein A {ECO:0000255|HAMAP-Rule:MF_00129};
GN   Name=mnmG {ECO:0000255|HAMAP-Rule:MF_00129};
GN   Synonyms=gidA {ECO:0000255|HAMAP-Rule:MF_00129};
GN   OrderedLocusNames=Oter_0883;
OS   Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1).
OC   Bacteria; Verrucomicrobia; Opitutae; Opitutales; Opitutaceae; Opitutus.
OX   NCBI_TaxID=452637;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11246 / JCM 15787 / PB90-1;
RX   PubMed=21398538; DOI=10.1128/jb.00228-11;
RA   van Passel M.W., Kant R., Palva A., Copeland A., Lucas S., Lapidus A.,
RA   Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J.,
RA   Larimer F.W., Land M.L., Hauser L., Kyrpides N., Mikhailova N.,
RA   Richardson P.P., Janssen P.H., de Vos W.M., Smidt H.;
RT   "Genome sequence of the verrucomicrobium Opitutus terrae PB90-1, an
RT   abundant inhabitant of rice paddy soil ecosystems.";
RL   J. Bacteriol. 193:2367-2368(2011).
CC   -!- FUNCTION: NAD-binding protein involved in the addition of a
CC       carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of
CC       certain tRNAs, forming tRNA-cmnm(5)s(2)U34. {ECO:0000255|HAMAP-
CC       Rule:MF_00129}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00129};
CC   -!- SUBUNIT: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
CC       {ECO:0000255|HAMAP-Rule:MF_00129}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00129}.
CC   -!- SIMILARITY: Belongs to the MnmG family. {ECO:0000255|HAMAP-
CC       Rule:MF_00129}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACB74171.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP001032; ACB74171.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_044891563.1; NC_010571.1.
DR   AlphaFoldDB; B1ZWP4; -.
DR   SMR; B1ZWP4; -.
DR   STRING; 452637.Oter_0883; -.
DR   EnsemblBacteria; ACB74171; ACB74171; Oter_0883.
DR   KEGG; ote:Oter_0883; -.
DR   eggNOG; COG0445; Bacteria.
DR   HOGENOM; CLU_007831_2_2_0; -.
DR   OrthoDB; 146811at2; -.
DR   Proteomes; UP000007013; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 1.10.150.570; -; 1.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_00129; MnmG_GidA; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR004416; MnmG.
DR   InterPro; IPR002218; MnmG-rel.
DR   InterPro; IPR020595; MnmG-rel_CS.
DR   InterPro; IPR026904; MnmG_C.
DR   InterPro; IPR044920; MnmG_C_subdom.
DR   InterPro; IPR040131; MnmG_N.
DR   PANTHER; PTHR11806; PTHR11806; 1.
DR   PANTHER; PTHR11806:SF0; PTHR11806:SF0; 1.
DR   Pfam; PF01134; GIDA; 1.
DR   Pfam; PF13932; GIDA_C; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR00136; gidA; 1.
DR   PROSITE; PS01280; GIDA_1; 1.
DR   PROSITE; PS01281; GIDA_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; FAD; Flavoprotein; NAD; Reference proteome; tRNA processing.
FT   CHAIN           1..634
FT                   /note="tRNA uridine 5-carboxymethylaminomethyl modification
FT                   enzyme MnmG"
FT                   /id="PRO_0000345310"
FT   BINDING         14..19
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00129"
FT   BINDING         292..306
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00129"
SQ   SEQUENCE   634 AA;  69723 MW;  0E75740F77C11E01 CRC64;
     MRFNSEPFDV IVCGAGHAGI EASLAAARVG AFTLLLTGNL DTVGQMSCNP AIGGQAKGQI
     VREIDALGGE MAINTDVTGI QFRLLNHTKG PAVQSPRAQC DKKAYQFRLK HTLELQPHLQ
     LFQATVTGLI FDGAKVIGCR TNLDIEFYGR TVVVTTGTFL RGLMHIGSNK NEGGRLGDFS
     ARTLSGSLQE AGIELRRFKT GTPPRLLGRS LDFSKMEEQK GDANPTFFAF HDTREDGGVF
     HVEHGKPQGE AIPPGCEQVS CWMTYTTART AELVRENLSR SAMYGGEIEG VGPRYCPSIE
     DKFVRFADKP RHLLFLEPEG RGTDEFYVNG LSTSLPFDVQ LELVHSIPGL GEAVLLRPAY
     AVEYDYAPPT QLKMSLESQR VEGLFLAGQI NGTSGYEEAA GQGLIAGVNA ARKGRGEQPL
     VLGRHEAYIG VLIDDLVTKG TEEPYRMFTS RAEHRLLLNH GSAELRLLHH ASGCKLLNVN
     RLDNIARKKE AIESWVRRLE SERTSEGTLA EIIRRQNARA ELPSELMRQS KPVRDEVLYR
     VLYSGYWERE QRHIDKLAQI EAVRIPAAID YLRIPGLRRE SALKLAAQRP DTLGQASRIS
     GVNPADVSIL MVLIKTGKTP SLPDTATTDG RDVP
 
 
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