MNN13_CANAL
ID MNN13_CANAL Reviewed; 764 AA.
AC Q5AGA9; A0A1D8PNG3;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Putative alpha-1,3-mannosyltransferase MNN13;
DE EC=2.4.1.-;
GN Name=MNN13; OrderedLocusNames=CAALFM_C502570WA;
GN ORFNames=CaO19.11746, CaO19.4270;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=21843869; DOI=10.1016/j.chom.2011.07.005;
RA Chen C., Pande K., French S.D., Tuch B.B., Noble S.M.;
RT "An iron homeostasis regulatory circuit with reciprocal roles in Candida
RT albicans commensalism and pathogenesis.";
RL Cell Host Microbe 10:118-135(2011).
RN [5]
RP IDENTIFICATION.
RX PubMed=23886038; DOI=10.1186/1756-0500-6-294;
RA Bates S., Hall R.A., Cheetham J., Netea M.G., MacCallum D.M., Brown A.J.,
RA Odds F.C., Gow N.A.;
RT "Role of the Candida albicans MNN1 gene family in cell wall structure and
RT virulence.";
RL BMC Res. Notes 6:294-294(2013).
CC -!- FUNCTION: Responsible for addition of the terminal mannose residues to
CC the outer chain of core N-linked polysaccharides and to O-linked
CC mannotriose. Implicated in late Golgi modifications (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}.
CC -!- INDUCTION: Expression is regulated by SEF1, SFU1, and HAP43.
CC {ECO:0000269|PubMed:21843869}.
CC -!- SIMILARITY: Belongs to the MNN1/MNT family. {ECO:0000305}.
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DR EMBL; CP017627; AOW29682.1; -; Genomic_DNA.
DR RefSeq; XP_720578.2; XM_715485.2.
DR AlphaFoldDB; Q5AGA9; -.
DR STRING; 237561.Q5AGA9; -.
DR GeneID; 3637720; -.
DR KEGG; cal:CAALFM_C502570WA; -.
DR CGD; CAL0000185691; MNN13.
DR VEuPathDB; FungiDB:C5_02570W_A; -.
DR eggNOG; ENOG502RZ48; Eukaryota.
DR HOGENOM; CLU_015387_0_0_1; -.
DR InParanoid; Q5AGA9; -.
DR OrthoDB; 527450at2759; -.
DR UniPathway; UPA00378; -.
DR PHI-base; PHI:3692; -.
DR PRO; PR:Q5AGA9; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000033; F:alpha-1,3-mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0046354; P:mannan biosynthetic process; IEA:UniProt.
DR GO; GO:0035268; P:protein mannosylation; IEA:UniProt.
DR GO; GO:0006493; P:protein O-linked glycosylation; IBA:GO_Central.
DR InterPro; IPR022751; Alpha_mannosyltransferase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF11051; Mannosyl_trans3; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane;
KW Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..764
FT /note="Putative alpha-1,3-mannosyltransferase MNN13"
FT /id="PRO_0000424326"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..764
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 204
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 764 AA; 89676 MW; 09FE536CC6E388F1 CRC64;
MIKPILGTKK IRRVICIIIG LFCILLLIGI FKHNSTNSVN NEASNFTVDF EEPSYTFPKT
VLFENNNNLD DLLLAKKNNW KFQSNVYNQL FMDHSIESVL SLSFNQRCEL LIRNIISQKV
SWIFDPLETF EINYESEDYI QFIQQEGIKL NKKFEKIKNN LKFKTSLNNF IKDEYKIIRS
KQYEQKIIDQ LTILRIFNKC FIKNGSKDQN DLVDRIIQEQ QKLVTKANSA ANGQSELELE
LKLKLKLTEN EKMVSELVED YVTLGKRVYP WISQRFPFYE RWNGDSYYYP PNYEEIFKDK
NEPLKSERST VRDSTSSPSI FLNQFKDASN GKGIVLSITE KHIDDTINLI RLLRALNNKL
PIQIIYFNDI SQSSKTKIIK AAREEINNFP KSYEKVYHGK QPSVPPSPPP PQEVWFVNIY
ESINPQHRNL FAKFDFKLLA SLFNSFNEFM LIDADTILMK SPEFFFNHQS YQQTGAFFFK
DRSPLLKRPI TDGEFLIKMG PSSIDSIMFD IPMMTQYTTH RELFKGLRLY MESGLVMIDK
QRRRHFNSIL MMNQLKFIHP ISNSMWGDKE LFWLGFAING DENYKFNNHF AAAIGQLTSN
QYNKDRRTPL KSKEICSSHP GHISDEDDRS LLWFNSGFRF CHEANNIDYQ EETKNNVILK
FLNGRHPLEF KKYYSDPLRI THAIVPPLNK NFQKMYNYDE EPTDGWTSEP NCNKYMWCAY
SSIGGRTGPE ETSHKETLDG LLVEYTPEEI AYFNYLGDVW VGKY
