MNN4_YEAST
ID MNN4_YEAST Reviewed; 1178 AA.
AC P36044; D6VX01; P36043; P89095;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Protein MNN4;
GN Name=MNN4; OrderedLocusNames=YKL201C; ORFNames=YKL200C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9023541; DOI=10.1093/glycob/6.8.805;
RA Odani T., Shimma Y., Tanaka A., Jigami Y.;
RT "Cloning and analysis of the MNN4 gene required for phosphorylation of N-
RT linked oligosaccharides in Saccharomyces cerevisiae.";
RL Glycobiology 6:805-810(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: May function as a positive regulator for mannosylphosphate
CC transferase. Is required to mediate mannosylphosphate transfer in both
CC the core and outer chain portions of N-linked oligosaccharides.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: To yeast YJR061w. {ECO:0000305}.
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DR EMBL; D83006; BAA11676.1; -; Genomic_DNA.
DR EMBL; Z28201; CAA82046.1; -; Genomic_DNA.
DR EMBL; Z28200; CAA82044.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA08967.1; -; Genomic_DNA.
DR PIR; S78475; S78475.
DR RefSeq; NP_012721.1; NM_001179766.1.
DR AlphaFoldDB; P36044; -.
DR BioGRID; 33921; 49.
DR DIP; DIP-4199N; -.
DR IntAct; P36044; 3.
DR STRING; 4932.YKL201C; -.
DR MaxQB; P36044; -.
DR PaxDb; P36044; -.
DR PRIDE; P36044; -.
DR EnsemblFungi; YKL201C_mRNA; YKL201C; YKL201C.
DR GeneID; 853634; -.
DR KEGG; sce:YKL201C; -.
DR SGD; S000001684; MNN4.
DR VEuPathDB; FungiDB:YKL201C; -.
DR eggNOG; ENOG502QREF; Eukaryota.
DR GeneTree; ENSGT00390000014471; -.
DR HOGENOM; CLU_008074_0_0_1; -.
DR InParanoid; P36044; -.
DR OMA; PEVYQLQ; -.
DR BioCyc; MetaCyc:G3O-31961-MON; -.
DR BioCyc; YEAST:G3O-31961-MON; -.
DR PRO; PR:P36044; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36044; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008047; F:enzyme activator activity; IMP:SGD.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR GO; GO:0006487; P:protein N-linked glycosylation; IMP:SGD.
DR GO; GO:0006493; P:protein O-linked glycosylation; IMP:SGD.
DR InterPro; IPR009644; FKTN-related.
DR InterPro; IPR007074; LicD_fam.
DR PANTHER; PTHR15407; PTHR15407; 1.
DR Pfam; PF04991; LicD; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1178
FT /note="Protein MNN4"
FT /id="PRO_0000096525"
FT TOPO_DOM 1..27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..1178
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REPEAT 1042..1049
FT /note="1"
FT REPEAT 1050..1057
FT /note="2"
FT REPEAT 1058..1065
FT /note="3"
FT REPEAT 1066..1073
FT /note="4"
FT REPEAT 1074..1081
FT /note="5"
FT REPEAT 1082..1089
FT /note="6"
FT REPEAT 1090..1097
FT /note="7; approximate"
FT REPEAT 1098..1105
FT /note="8"
FT REPEAT 1106..1113
FT /note="9; approximate"
FT REPEAT 1114..1121
FT /note="10; approximate"
FT REPEAT 1122..1129
FT /note="11; approximate"
FT REPEAT 1130..1137
FT /note="12"
FT REPEAT 1138..1144
FT /note="13; approximate"
FT REPEAT 1145..1152
FT /note="14; approximate"
FT REPEAT 1153..1160
FT /note="15; approximate"
FT REPEAT 1161..1168
FT /note="16; approximate"
FT REPEAT 1169..1174
FT /note="17; truncated"
FT REGION 1041..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1174
FT /note="17 X 8 AA tandem repeats of K-K-K-K-E-E-E-E"
SQ SEQUENCE 1178 AA; 139381 MW; BC05DAE0AEFCB282 CRC64;
MLQRISSKLH RRFLSGLLRV KHYPLRRILL PLILLQIIII TFIWSNSPQR NGLGRDADYL
LPNYNELDSD DDSWYSILTS SFKNDRKIQF AKTLYENLKF GTNPKWVNEY TLQNDLLSVK
MGPRKGSKLE SVDELKFYDF DPRLTWSVVL NHLQNNDADQ PEKLPFSWYD WTTFHELNKL
ISIDKTVLPC NFLFQSAFDK ESLEAIETEL GEPLFLYERP KYAQKLWYKA ARNQDRIKDS
KELKKHCSKL FTPDGHGSPK GLRFNTQFQI KELYDKVRPE VYQLQARNYI LTTQSHPLSI
SIIESDNSTY QVPLQTEKSK NLVQSGLLQE YINDNINSTN KRKKNKQDVE FNHNRLFQEF
VNNDQVNSLY KLEIEETDKF TFDKDLVYLS PSDFKFDASK KIEELEEQKK LYPDKFSAHN
ENYLNSLKNS VKTSPALQRK FFYEAGAVKQ YKGMGFHRDK RFFNVDTLIN DKQEYQARLN
SMIRTFQKFT KANGIISWLS HGTLYGYLYN GMAFPWDNDF DLQMPIKHLQ LLSQYFNQSL
ILEDPRQGNG RYFLDVSDSL TVRINGNGKN NIDARFIDVD TGLYIDITGL ASTSAPSRDY
LNSYIEERLQ EEHLDINNIP ESNGETATLP DKVDDGLVNM ATLNITELRD YITSDENKNH
KRVPTDTDLK DLLKKELEEL PKSKTIENKL NPKQRYFLNE KLKLYNCRNN HFNSFEELSP
LINTVFHGVP ALIPHRHTYC LHNEYHVPDR YAFDAYKNTA YLPEFRFWFD YDGLKKCSNI
NSWYPNIPSI NSWNPNLLKE ISSTKFESKL FDSNKVSEYS FKNLSMDDVR LIYKNIPKAG
FIEVFTNLYN SFNVTAYRQK ELEIQYCQNL TFIEKKKLLH QLRINVAPKL SSPAKDPFLF
GYEKAMWKDL SKSMNQTTLD QVTKIVHEEY VGKIIDLSES LKYRNFSLFN ITFDETGTTL
DDNTEDYTPA NTVEVNPVDF KSNLNFSSNS FLDLNSYGLD LFAPTLSDVN RKGIQMFDKD
PIIVYEDYAY AKLLEERKRR EKKKKEEEEK KKKEEEEKKK KEEEEKKKKE EEEKKKKEEE
EKKKKEEEEK KKQEEEEKKK KEEEEKKKQE EGEKMKNEDE ENKKNEDEEK KKNEEEEKKK
QEEKNKKNED EEKKKQEEEE KKKNEEEEKK KQEEGHSN
