MNS1_BOVIN
ID MNS1_BOVIN Reviewed; 495 AA.
AC Q2KIQ2; F1MH18;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Meiosis-specific nuclear structural protein 1;
GN Name=MNS1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000312|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007744|PDB:7RRO}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.40 ANGSTROMS), SUBCELLULAR LOCATION,
RP AND TISSUE SPECIFICITY.
RX PubMed=34715025; DOI=10.1016/j.cell.2021.10.007;
RA Gui M., Farley H., Anujan P., Anderson J.R., Maxwell D.W., Whitchurch J.B.,
RA Botsch J.J., Qiu T., Meleppattu S., Singh S.K., Zhang Q., Thompson J.,
RA Lucas J.S., Bingle C.D., Norris D.P., Roy S., Brown A.;
RT "De novo identification of mammalian ciliary motility proteins using cryo-
RT EM.";
RL Cell 184:5791-5806.e19(2021).
CC -!- FUNCTION: May play a role in the control of meiotic division and germ
CC cell differentiation through regulation of pairing and recombination
CC during meiosis (By similarity). Required for sperm flagella assembly
CC (By similarity). May play a role in the assembly and function of the
CC outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein
CC arms (ODA) binding onto the axonemal doublet microtubules (By
CC similarity). {ECO:0000250|UniProtKB:Q61884,
CC ECO:0000250|UniProtKB:Q8NEH6}.
CC -!- SUBUNIT: Able to form oligomers (By similarity). Interacts with ODAD1
CC (By similarity). {ECO:0000250|UniProtKB:Q61884,
CC ECO:0000250|UniProtKB:Q8NEH6}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61884}.
CC Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:34715025}.
CC Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:Q8NEH6}. Note=Microtubule inner protein (MIP)
CC part of the dynein-decorated doublet microtubules (DMTs) in cilia
CC axoneme. {ECO:0000269|PubMed:34715025}.
CC -!- TISSUE SPECIFICITY: Expressed in trachea multiciliated cells.
CC {ECO:0000269|PubMed:34715025}.
CC -!- SIMILARITY: Belongs to the MNS1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI12554.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC112553; AAI12554.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001039803.2; NM_001046338.2.
DR RefSeq; XP_005211752.1; XM_005211695.3.
DR PDB; 7RRO; EM; 3.40 A; A/B=1-494.
DR PDBsum; 7RRO; -.
DR AlphaFoldDB; Q2KIQ2; -.
DR SMR; Q2KIQ2; -.
DR PaxDb; Q2KIQ2; -.
DR PRIDE; Q2KIQ2; -.
DR Ensembl; ENSBTAT00000000337.5; ENSBTAP00000000337.4; ENSBTAG00000000271.6.
DR GeneID; 532884; -.
DR KEGG; bta:532884; -.
DR CTD; 55329; -.
DR VEuPathDB; HostDB:ENSBTAG00000000271; -.
DR VGNC; VGNC:31539; MNS1.
DR eggNOG; ENOG502QS9D; Eukaryota.
DR GeneTree; ENSGT00730000111210; -.
DR HOGENOM; CLU_034848_0_0_1; -.
DR InParanoid; Q2KIQ2; -.
DR OMA; EHKRFLR; -.
DR OrthoDB; 962490at2759; -.
DR TreeFam; TF329219; -.
DR Proteomes; UP000009136; Chromosome 10.
DR Proteomes; UP000009136; Unplaced.
DR Bgee; ENSBTAG00000000271; Expressed in thymus and 106 other tissues.
DR ExpressionAtlas; Q2KIQ2; baseline.
DR GO; GO:0005879; C:axonemal microtubule; IDA:UniProtKB.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR026504; MNS1.
DR InterPro; IPR043597; TPH_dom.
DR PANTHER; PTHR19265; PTHR19265; 1.
DR Pfam; PF13868; TPH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium; Coiled coil; Cytoplasm;
KW Cytoskeleton; Flagellum; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..495
FT /note="Meiosis-specific nuclear structural protein 1"
FT /id="PRO_0000298920"
FT REGION 172..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..215
FT /evidence="ECO:0000255"
FT COILED 245..361
FT /evidence="ECO:0000255"
FT CONFLICT 150
FT /note="G -> E (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="G -> E (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 291..294
FT /note="KVKK -> SEE (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="P -> Q (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 60419 MW; 6EC8413784A74BBA CRC64;
MASIRRTLSF SERHQKLVDI NYCKKLHVEA LQRLQNQTRD QMVQNENDDR AERKRFLRLL
QDEQFELDME EAIQKAEENK RLRELQLAQE EKLATELAKL KRESLKDEKL RQQVRENSAE
LRELEKKLKA AYMNKERAAQ IAEKDAIKYG QMKRDAEIAR TMMEEHERLI KEESAAEDKR
NQAKAQYSHD LEKQLEEQGK KKQEAYEQLL KEKLMIDEIV RKIYEEDQLE RQQRLEKMNT
TRRYIEEFQK EQALWRKKKR EEMEEENRKI IEFAKLQQQR EEDRMAKVQE KVKKKRLQLK
NMLTQRLEEM LRQREDLEQV RQELYQEEQA EIYKKKLEEE AEEKLRKQKE LKQDFMDQMA
LKELILQAAK EEEETFRKAM LAKFAEDDRI ELMNAQKPRM KQLEHKRAVE KLIEERRNQF
LADKQRELEE WQWQQRRQGC INAIVEEERL KLLKEHATKL LGYLPKGVFK NEDDIDMLGE
EFRKAYQKRS EICEK
