ID   MNS1_MACFA              Reviewed;         495 AA.
AC   Q4R7T8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 2.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Meiosis-specific nuclear structural protein 1;
GN   Name=MNS1; ORFNames=QtsA-14410;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the control of meiotic division and germ
CC       cell differentiation through regulation of pairing and recombination
CC       during meiosis (By similarity). Required for sperm flagella assembly
CC       (By similarity). May play a role in the assembly and function of the
CC       outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein
CC       arms (ODA) binding onto the axonemal doublet microtubules (By
CC       similarity). {ECO:0000250|UniProtKB:Q61884,
CC       ECO:0000250|UniProtKB:Q8NEH6}.
CC   -!- SUBUNIT: Able to form oligomers (By similarity). Interacts with ODAD1
CC       (By similarity). {ECO:0000250|UniProtKB:Q61884,
CC       ECO:0000250|UniProtKB:Q8NEH6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61884}.
CC       Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q2KIQ2}.
CC       Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:Q8NEH6}. Note=Microtubule inner protein (MIP)
CC       part of the dynein-decorated doublet microtubules (DMTs) in cilia
CC       axoneme. {ECO:0000250|UniProtKB:Q2KIQ2}.
CC   -!- SIMILARITY: Belongs to the MNS1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE00834.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE00834.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB168724; BAE00834.1; ALT_SEQ; mRNA.
DR   AlphaFoldDB; Q4R7T8; -.
DR   SMR; Q4R7T8; -.
DR   STRING; 9541.XP_005559687.1; -.
DR   PRIDE; Q4R7T8; -.
DR   eggNOG; ENOG502QS9D; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR026504; MNS1.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR19265; PTHR19265; 1.
DR   Pfam; PF13868; TPH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Meiosis; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..495
FT                   /note="Meiosis-specific nuclear structural protein 1"
FT                   /id="PRO_0000298922"
FT   COILED          59..410
FT                   /evidence="ECO:0000255"
FT   MOD_RES         188
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q61884"
SQ   SEQUENCE   495 AA;  60687 MW;  FFECD873D20E00B4 CRC64;
     MASKRRNMSC SERHQKLVDE NYCKKLHVQA LKNINSQIRN RMVQNENDNR VERKQFLRLL
     QNEQFELDME EAIQKAEENK RLKELLLKQE EKLAMELAKL KHESLKDEKM RQQVRENSIE
     LRELEKKLKA AYMNKERAAQ IAEKDAIKYE QMKRDAEIAK TMMEEHKRII KEENAAEDKR
     NKVKAQYYLD LEKQLEEQEK KKQEAYEQLL KEKLMIDEIV RKIYEEDRLE KQQKLEKMNA
     MRRYIEEFQK EQALWRKKKR EEMEEENRKI IEFANMQQQR EEDRMAKVQE NEEKRLQLQN
     ALTQKLEEML RQREDLEQVQ QELYQEEQAE IYKRKLKEEA EKKLRKQKEM KQDFEEQMAL
     KELVLQAAKE EEENFRKTML AKFAEDDRIE LMNAQKQRMK QLEHRRAVEK LIEERRQQFL
     ADKQQELEEW QLQQRRQGFI NAIIEEERLK LLKEHATNLL GYLPKGVFKK EDDIDLLGEE
     FRKVYQQRSE ICEDK