ID   MNS1_XENTR              Reviewed;         498 AA.
AC   A4IJ21;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Meiosis-specific nuclear structural protein 1;
GN   Name=mns1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in the control of meiotic division and germ
CC       cell differentiation through regulation of pairing and recombination
CC       during meiosis (By similarity). Required for sperm flagella assembly
CC       (By similarity). May play a role in the assembly and function of the
CC       outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein
CC       arms (ODA) binding onto the axonemal doublet microtubules (By
CC       similarity). {ECO:0000250|UniProtKB:Q61884,
CC       ECO:0000250|UniProtKB:Q8NEH6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61884}.
CC       Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q2KIQ2}.
CC       Cytoplasm, cytoskeleton, flagellum axoneme
CC       {ECO:0000250|UniProtKB:Q8NEH6}. Note=Microtubule inner protein (MIP)
CC       part of the dynein-decorated doublet microtubules (DMTs) in cilia
CC       axoneme. {ECO:0000250|UniProtKB:Q2KIQ2}.
CC   -!- SIMILARITY: Belongs to the MNS1 family. {ECO:0000305}.
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DR   EMBL; BC136246; AAI36247.1; -; mRNA.
DR   RefSeq; NP_001096482.1; NM_001103012.2.
DR   AlphaFoldDB; A4IJ21; -.
DR   SMR; A4IJ21; -.
DR   PaxDb; A4IJ21; -.
DR   DNASU; 100125104; -.
DR   Ensembl; ENSXETT00000036083; ENSXETP00000036083; ENSXETG00000016556.
DR   GeneID; 100125104; -.
DR   KEGG; xtr:100125104; -.
DR   CTD; 55329; -.
DR   Xenbase; XB-GENE-1008457; mns1.
DR   eggNOG; ENOG502QS9D; Eukaryota.
DR   HOGENOM; CLU_034848_0_0_1; -.
DR   InParanoid; A4IJ21; -.
DR   OrthoDB; 962490at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016556; Expressed in testis and 11 other tissues.
DR   GO; GO:0005879; C:axonemal microtubule; ISS:UniProtKB.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0044782; P:cilium organization; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR026504; MNS1.
DR   InterPro; IPR043597; TPH_dom.
DR   PANTHER; PTHR19265; PTHR19265; 1.
DR   Pfam; PF13868; TPH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum;
KW   Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..498
FT                   /note="Meiosis-specific nuclear structural protein 1"
FT                   /id="PRO_0000298926"
FT   COILED          45..211
FT                   /evidence="ECO:0000255"
FT   COILED          270..348
FT                   /evidence="ECO:0000255"
FT   COILED          385..450
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  61607 MW;  34BE37488D88D5EE CRC64;
     MMMSRKNVTY RQREKLIAEA QRQEFLREDR IKHLNYEQQM AESLKSEERV EKKRFLQRLQ
     NEEHEKRMDE AIQLGEESRR LKERQLEQEE RMALEMARIK HEKLKDEKIR QQIRENSTEL
     RELEQKLKAA YLNRERAAQI AEKEVLKYEQ MKEDLETVRK MQKDQERAED EEIVRETKRY
     QEKLNYQIEL ERQLEEKEKT RQEAYHEFLK EKILIDEIVR KIYEEDQMET QLKLEKMNAT
     RRYIEEFKEQ QQTWRNMEQT RMEEENRKIL AFANMQQRRE EDRMAEVRER EQQKKALQEK
     LAEQIQKEQQ QREELEQMRE ELYLEEQAEE ARQKAISEME KKIRQRLEMQ QTFEEQMAFK
     QIVQQAAKEE EEAFVQAMLA KFAEDDRIEQ MNAQKRRMKQ LEHKRAVEKL LEERRQQFIA
     DKERELQERQ EEERRESFRR AIIEEERQKI LKQHATQLLG YLPKGIFKGE DDLNLFDEGF
     RQDFQKRRAD ISSNDGWD