MNS60_HUMAN
ID MNS60_HUMAN Reviewed; 130 AA.
AC P0DW28;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 03-AUG-2022, sequence version 1.
DT 03-AUG-2022, entry version 1.
DE RecName: Full=Ribosome biogenesis inhibitor MINAS-60 {ECO:0000305};
DE Short=MINAS-60 {ECO:0000303|PubMed:35393574};
GN Name=RBM10 {ECO:0000303|PubMed:35393574, ECO:0000312|HGNC:HGNC:9896};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY,
RP DEVELOPMENTAL STAGE, AND INTERACTION WITH GTPBP4 AND MRTO4.
RX PubMed=35393574; DOI=10.1038/s41589-022-01003-9;
RA Cao X., Khitun A., Harold C.M., Bryant C.J., Zheng S.J., Baserga S.J.,
RA Slavoff S.A.;
RT "Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint
RT inhibitor.";
RL Nat. Chem. Biol. 0:0-0(2022).
CC -!- FUNCTION: Acts as a late-stage inhibitor of pre-60S ribosome assembly
CC by preventing pre-60S ribosome export from nucleus.
CC {ECO:0000269|PubMed:35393574}.
CC -!- SUBUNIT: Interacts with 60S ribosome assembly factors GTPBP4 and MRTO4.
CC {ECO:0000269|PubMed:35393574}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305|PubMed:35393574}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing, Alternative initiation; Named isoforms=6;
CC Name=Ribosome biogenesis inhibitor MINAS-60;
CC IsoId=P0DW28-1; Sequence=Displayed;
CC Name=1;
CC IsoId=P98175-1; Sequence=External;
CC Name=2;
CC IsoId=P98175-2; Sequence=External;
CC Name=3;
CC IsoId=P98175-3; Sequence=External;
CC Name=4;
CC IsoId=P98175-4; Sequence=External;
CC Name=5;
CC IsoId=P98175-5; Sequence=External;
CC -!- DEVELOPMENTAL STAGE: Increases at early S phase and peaks during S
CC phase (PubMed:35393574). Decreases by late S phase and is very low
CC during G2/M (PubMed:35393574). At G1, it again increases
CC (PubMed:35393574). {ECO:0000269|PubMed:35393574}.
CC -!- MISCELLANEOUS: MINAS-60 is the product of an alternative open reading
CC frame (alt-ORF) of transcripts coding for the RBM10 (AC P98175) protein
CC (PubMed:35393574). MINAS-60 and RBM10 ORFs are overlapping and are
CC formed by shifting the reading frame (PubMed:35393574).
CC {ECO:0000269|PubMed:35393574}.
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DR EMBL; AL513366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004181; -; NOT_ANNOTATED_CDS; mRNA.
DR HGNC; HGNC:9896; RBM10.
DR Proteomes; UP000005640; Chromosome X.
PE 1: Evidence at protein level;
KW Alternative initiation; Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..130
FT /note="Ribosome biogenesis inhibitor MINAS-60"
FT /id="PRO_0000456281"
SQ SEQUENCE 130 AA; 14216 MW; 1933399C50DF1B6D CRC64;
MKDVVVVVTG LAAMEPLTAR RMMVGRTAAE TTTTGTWTTV HILASMAARR ASMTMTTHLR
SRVRRIPTRP PRAPRLSVGG GGGTGTAPPA RQASPETATI GTRTIGPSKG RRRRRRRMRR
RRRRPVTSSC
