MNT4_CANAL
ID MNT4_CANAL Reviewed; 719 AA.
AC Q59MZ9; A0A1D8PST3;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Putative alpha-1,3-mannosyltransferase MNT4;
DE EC=2.4.1.-;
GN Name=MNT4; Synonyms=MNN16; OrderedLocusNames=CAALFM_CR04800WA;
GN ORFNames=CaO19.13690, CaO19.6313;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=15387822; DOI=10.1111/j.1365-2958.2004.04214.x;
RA Lan C.Y., Rodarte G., Murillo L.A., Jones T., Davis R.W., Dungan J.,
RA Newport G., Agabian N.;
RT "Regulatory networks affected by iron availability in Candida albicans.";
RL Mol. Microbiol. 53:1451-1469(2004).
RN [5]
RP IDENTIFICATION.
RX PubMed=23886038; DOI=10.1186/1756-0500-6-294;
RA Bates S., Hall R.A., Cheetham J., Netea M.G., MacCallum D.M., Brown A.J.,
RA Odds F.C., Gow N.A.;
RT "Role of the Candida albicans MNN1 gene family in cell wall structure and
RT virulence.";
RL BMC Res. Notes 6:294-294(2013).
CC -!- FUNCTION: Responsible for addition of the terminal mannose residues to
CC the outer chain of core N-linked polysaccharides and to O-linked
CC mannotriose. Implicated in late Golgi modifications (By similarity).
CC {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}.
CC -!- INDUCTION: induced in low iron conditions.
CC {ECO:0000269|PubMed:15387822}.
CC -!- SIMILARITY: Belongs to the MNN1/MNT family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31213.1; -; Genomic_DNA.
DR RefSeq; XP_711098.1; XM_706006.1.
DR AlphaFoldDB; Q59MZ9; -.
DR STRING; 237561.Q59MZ9; -.
DR GeneID; 3647300; -.
DR KEGG; cal:CAALFM_CR04800WA; -.
DR CGD; CAL0000182375; MNT4.
DR VEuPathDB; FungiDB:CR_04800W_A; -.
DR eggNOG; ENOG502T9W7; Eukaryota.
DR HOGENOM; CLU_028276_0_0_1; -.
DR InParanoid; Q59MZ9; -.
DR OrthoDB; 527450at2759; -.
DR UniPathway; UPA00378; -.
DR PHI-base; PHI:3695; -.
DR PRO; PR:Q59MZ9; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000033; F:alpha-1,3-mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006493; P:protein O-linked glycosylation; IBA:GO_Central.
DR InterPro; IPR022751; Alpha_mannosyltransferase.
DR Pfam; PF11051; Mannosyl_trans3; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane;
KW Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..719
FT /note="Putative alpha-1,3-mannosyltransferase MNT4"
FT /id="PRO_0000424329"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..719
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 273
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 449
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 719 AA; 83976 MW; 4E37C3A03EA418BE CRC64;
MKFHLKRYVI VTSILLSFFL LFRRQFLPLT QRQPNPINNE LVSFDLIKQR NKFENPIYAK
WKLSSSSPLE TDLTTRCNDY FQQLLTQENF QINYHDSGYK TEPFVYKRKK WLKERIRSLR
KQYKFDKNKD KYDFDQIAKQ EFSIVSKNQS IHELNIYQHF SHTRIFGKCF ATNNNNNNNN
GVINMENPQS NQLCKSFVQK LYPWMSGNLP IFERNKERSP PQLDDSTDCI IEQIYKNSKG
KGKGIIIPLM TQDKSNNQIQ NIGRLIKVLR GLNNTLPIEI TFMELITPEA KQQLYDIATS
DSQMYPTKQD IAFVDLSPTT TNQVKGSISD SSIITLSSIF TSFEEFIILN QHIIPLIELT
KFFNNERYKL HGTYFFKSPS KLKYRTTKFN IGFHEIASFI KNQLIPNKFD KHYFNLYQKG
SENGDEVTID RFFNYQFNNL IDSSLIIFNK SKTLSGLLIS GNFEFLYHDD LFNIRINNTP
TKTKMDYLWL GQYISGINEQ IIFNFNYAIM PGILTPSQNL PKDSIECLEI CSSSWGQLSD
IDDISLLYIT SHQLQNWLNH QKFFESLLKD KYEFKFNELV DNFLITNTNT NTNTNTNTNG
NTNDKDSTKL TMGRIDLSIF EKIKTQPLKI ETIIRPPTLI EPINVLGYNE PDQAWVHQDD
FDRIGQNGQG QGQGQGHPFY CVYSSIGDPL KEGIRGLSIN VEQSLQKKYK KLIEIWLQD
