ID   MNTB_BACSU              Reviewed;         250 AA.
AC   O34338;
DT   11-JUL-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Manganese transport system ATP-binding protein MntB;
GN   Name=mntB {ECO:0000303|PubMed:10760146}; Synonyms=ytgB;
GN   OrderedLocusNames=BSU30760;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT   200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   POSSIBLE FUNCTION.
RX   PubMed=10760146; DOI=10.1046/j.1365-2958.2000.01811.x;
RA   Que Q., Helmann J.D.;
RT   "Manganese homeostasis in Bacillus subtilis is regulated by MntR, a
RT   bifunctional regulator related to the diphtheria toxin repressor family of
RT   proteins.";
RL   Mol. Microbiol. 35:1454-1468(2000).
RN   [4]
RP   INDUCTION.
RX   PubMed=12950915; DOI=10.1046/j.1365-2958.2003.03648.x;
RA   Guedon E., Moore C.M., Que Q., Wang T., Ye R.W., Helmann J.D.;
RT   "The global transcriptional response of Bacillus subtilis to manganese
RT   involves the MntR, Fur, TnrA and sigmaB regulons.";
RL   Mol. Microbiol. 49:1477-1491(2003).
CC   -!- FUNCTION: Probably part of the ABC transporter complex MntABCD involved
CC       in manganese import. Probably responsible for energy coupling to the
CC       transport system. {ECO:0000305|PubMed:10760146}.
CC   -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC       (MntB), two transmembrane proteins (MntC and MntD) and a solute-binding
CC       protein (MntA). {ECO:0000305|PubMed:10760146}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by MntR in the presence of manganese.
CC       {ECO:0000269|PubMed:12950915}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; AF008220; AAC00230.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15054.1; -; Genomic_DNA.
DR   PIR; C69992; C69992.
DR   RefSeq; NP_390954.1; NC_000964.3.
DR   RefSeq; WP_004398644.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O34338; -.
DR   SMR; O34338; -.
DR   STRING; 224308.BSU30760; -.
DR   PaxDb; O34338; -.
DR   PRIDE; O34338; -.
DR   EnsemblBacteria; CAB15054; CAB15054; BSU_30760.
DR   GeneID; 937196; -.
DR   KEGG; bsu:BSU30760; -.
DR   PATRIC; fig|224308.179.peg.3334; -.
DR   eggNOG; COG1121; Bacteria.
DR   InParanoid; O34338; -.
DR   OMA; IAVLHDF; -.
DR   PhylomeDB; O34338; -.
DR   BioCyc; BSUB:BSU30760-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cell membrane; Ion transport; Membrane; Nucleotide-binding;
KW   Reference proteome; Transport.
FT   CHAIN           1..250
FT                   /note="Manganese transport system ATP-binding protein MntB"
FT                   /id="PRO_0000092524"
FT   DOMAIN          4..236
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         36..43
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   250 AA;  27881 MW;  12A3867A49E2208B CRC64;
     MFPVELDNVT VAYHKKPVLQ DISLQVPEGK LIGIIGPNGA GKSTLIKTIL GLVPRASGDI
     SIYGKDYKDQ RTRIGYVPQR GSVDWDFPTS PLDVVLMGRY GRIGLLKRPK KADVEMAKAA
     LTKVGMHDYA KRQISQLSGG QQQRVFLARA LCQNADIYFM DEPFAGVDAA TERAIMTLLA
     ELKEKGKTVL VVHHDLQTAE DYFDWILLLH LRKIAFGPTE NVFTIENLQK TYGGRLTFLK
     DKVLAEGHKE