MNTD_BACSU
ID MNTD_BACSU Reviewed; 295 AA.
AC O34500;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Manganese transport system membrane protein MntD;
GN Name=mntD {ECO:0000303|PubMed:10760146}; Synonyms=ytgD;
GN OrderedLocusNames=BSU30740;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT 200 kb rrnB-dnaB region.";
RL Microbiology 143:3431-3441(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP POSSIBLE FUNCTION.
RX PubMed=10760146; DOI=10.1046/j.1365-2958.2000.01811.x;
RA Que Q., Helmann J.D.;
RT "Manganese homeostasis in Bacillus subtilis is regulated by MntR, a
RT bifunctional regulator related to the diphtheria toxin repressor family of
RT proteins.";
RL Mol. Microbiol. 35:1454-1468(2000).
RN [4]
RP INDUCTION.
RX PubMed=12950915; DOI=10.1046/j.1365-2958.2003.03648.x;
RA Guedon E., Moore C.M., Que Q., Wang T., Ye R.W., Helmann J.D.;
RT "The global transcriptional response of Bacillus subtilis to manganese
RT involves the MntR, Fur, TnrA and sigmaB regulons.";
RL Mol. Microbiol. 49:1477-1491(2003).
CC -!- FUNCTION: Probably part of the ABC transporter complex MntABCD involved
CC in manganese import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000305|PubMed:10760146}.
CC -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC (MntB), two transmembrane proteins (MntC and MntD) and a solute-binding
CC protein (MntA). {ECO:0000305|PubMed:10760146}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Repressed by MntR in the presence of manganese.
CC {ECO:0000269|PubMed:12950915}.
CC -!- SIMILARITY: Belongs to the ABC-3 integral membrane protein family.
CC {ECO:0000305}.
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DR EMBL; AF008220; AAC00232.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15052.1; -; Genomic_DNA.
DR PIR; E69992; E69992.
DR RefSeq; NP_390952.1; NC_000964.3.
DR RefSeq; WP_003229067.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; O34500; -.
DR SMR; O34500; -.
DR STRING; 224308.BSU30740; -.
DR PaxDb; O34500; -.
DR EnsemblBacteria; CAB15052; CAB15052; BSU_30740.
DR GeneID; 937149; -.
DR KEGG; bsu:BSU30740; -.
DR PATRIC; fig|224308.179.peg.3332; -.
DR eggNOG; COG1108; Bacteria.
DR InParanoid; O34500; -.
DR OMA; CALLSCW; -.
DR PhylomeDB; O34500; -.
DR BioCyc; BSUB:BSU30740-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR001626; ABC_TroCD.
DR PANTHER; PTHR30477; PTHR30477; 1.
DR Pfam; PF00950; ABC-3; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..295
FT /note="Manganese transport system membrane protein MntD"
FT /id="PRO_0000171153"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 295 AA; 31058 MW; 6C192B81839070BF CRC64;
MSFEAWIIAT GVLVGVSCGL IGTFLVLRSM AMLADAISHT VLLGIVGAFL VTGSLDGIYM
FIGAAATGLL TAFLVQLLHS KGVQSDAAIG VVFTSLFAIG VILLSVYGAN VHLDIEHSLM
GEIAFVPWNT VTVFGVDIGP KAFWMLASVL VLNVVLISVC YKEFKIASFD PQMALALGIP
VLLIHYVQMG MLSLTTVASF DSVGAVLVVA MLIVPPAAAH LLTDRLLYML ILSALIGGLS
AVMGYFFATW LNVSISGAMA AMTGVCYASA FLFSPANGVI TKKLRTLNMQ KERAG
