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MNTD_BACSU
ID   MNTD_BACSU              Reviewed;         295 AA.
AC   O34500;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Manganese transport system membrane protein MntD;
GN   Name=mntD {ECO:0000303|PubMed:10760146}; Synonyms=ytgD;
GN   OrderedLocusNames=BSU30740;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9387221; DOI=10.1099/00221287-143-11-3431;
RA   Lapidus A., Galleron N., Sorokin A., Ehrlich S.D.;
RT   "Sequencing and functional annotation of the Bacillus subtilis genes in the
RT   200 kb rrnB-dnaB region.";
RL   Microbiology 143:3431-3441(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   POSSIBLE FUNCTION.
RX   PubMed=10760146; DOI=10.1046/j.1365-2958.2000.01811.x;
RA   Que Q., Helmann J.D.;
RT   "Manganese homeostasis in Bacillus subtilis is regulated by MntR, a
RT   bifunctional regulator related to the diphtheria toxin repressor family of
RT   proteins.";
RL   Mol. Microbiol. 35:1454-1468(2000).
RN   [4]
RP   INDUCTION.
RX   PubMed=12950915; DOI=10.1046/j.1365-2958.2003.03648.x;
RA   Guedon E., Moore C.M., Que Q., Wang T., Ye R.W., Helmann J.D.;
RT   "The global transcriptional response of Bacillus subtilis to manganese
RT   involves the MntR, Fur, TnrA and sigmaB regulons.";
RL   Mol. Microbiol. 49:1477-1491(2003).
CC   -!- FUNCTION: Probably part of the ABC transporter complex MntABCD involved
CC       in manganese import. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000305|PubMed:10760146}.
CC   -!- SUBUNIT: The complex is probably composed of two ATP-binding proteins
CC       (MntB), two transmembrane proteins (MntC and MntD) and a solute-binding
CC       protein (MntA). {ECO:0000305|PubMed:10760146}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by MntR in the presence of manganese.
CC       {ECO:0000269|PubMed:12950915}.
CC   -!- SIMILARITY: Belongs to the ABC-3 integral membrane protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF008220; AAC00232.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15052.1; -; Genomic_DNA.
DR   PIR; E69992; E69992.
DR   RefSeq; NP_390952.1; NC_000964.3.
DR   RefSeq; WP_003229067.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O34500; -.
DR   SMR; O34500; -.
DR   STRING; 224308.BSU30740; -.
DR   PaxDb; O34500; -.
DR   EnsemblBacteria; CAB15052; CAB15052; BSU_30740.
DR   GeneID; 937149; -.
DR   KEGG; bsu:BSU30740; -.
DR   PATRIC; fig|224308.179.peg.3332; -.
DR   eggNOG; COG1108; Bacteria.
DR   InParanoid; O34500; -.
DR   OMA; CALLSCW; -.
DR   PhylomeDB; O34500; -.
DR   BioCyc; BSUB:BSU30740-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0010043; P:response to zinc ion; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR001626; ABC_TroCD.
DR   PANTHER; PTHR30477; PTHR30477; 1.
DR   Pfam; PF00950; ABC-3; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..295
FT                   /note="Manganese transport system membrane protein MntD"
FT                   /id="PRO_0000171153"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   295 AA;  31058 MW;  6C192B81839070BF CRC64;
     MSFEAWIIAT GVLVGVSCGL IGTFLVLRSM AMLADAISHT VLLGIVGAFL VTGSLDGIYM
     FIGAAATGLL TAFLVQLLHS KGVQSDAAIG VVFTSLFAIG VILLSVYGAN VHLDIEHSLM
     GEIAFVPWNT VTVFGVDIGP KAFWMLASVL VLNVVLISVC YKEFKIASFD PQMALALGIP
     VLLIHYVQMG MLSLTTVASF DSVGAVLVVA MLIVPPAAAH LLTDRLLYML ILSALIGGLS
     AVMGYFFATW LNVSISGAMA AMTGVCYASA FLFSPANGVI TKKLRTLNMQ KERAG
 
 
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