MNTH1_PSEAE
ID MNTH1_PSEAE Reviewed; 439 AA.
AC Q9RPF3; Q9HW67;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Divalent metal cation transporter MntH 1 {ECO:0000255|HAMAP-Rule:MF_00221};
GN Name=mntH1 {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=PA4334;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 47053 / PAO1024 / MM2002;
RX PubMed=10844693; DOI=10.1046/j.1365-2958.2000.01922.x;
RA Kehres D.G., Zaharik M.L., Finlay B.B., Maguire M.E.;
RT "The NRAMP proteins of Salmonella typhimurium and Escherichia coli are
RT selective manganese transporters involved in the response to reactive
RT oxygen.";
RL Mol. Microbiol. 36:1085-1100(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD46618.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAG07722.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF161319; AAD46618.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE004091; AAG07722.1; ALT_INIT; Genomic_DNA.
DR PIR; B83105; B83105.
DR RefSeq; NP_253024.1; NC_002516.2.
DR AlphaFoldDB; Q9RPF3; -.
DR SMR; Q9RPF3; -.
DR STRING; 287.DR97_1510; -.
DR PaxDb; Q9RPF3; -.
DR PRIDE; Q9RPF3; -.
DR EnsemblBacteria; AAG07722; AAG07722; PA4334.
DR GeneID; 881479; -.
DR KEGG; pae:PA4334; -.
DR PATRIC; fig|208964.12.peg.4539; -.
DR PseudoCAP; PA4334; -.
DR HOGENOM; CLU_020088_2_0_6; -.
DR InParanoid; Q9RPF3; -.
DR OMA; YDETEKV; -.
DR PhylomeDB; Q9RPF3; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071281; P:cellular response to iron ion; IBA:GO_Central.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..439
FT /note="Divalent metal cation transporter MntH 1"
FT /id="PRO_0000212628"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 418..438
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ SEQUENCE 439 AA; 46603 MW; C72EA125D5529768 CRC64;
MKYSLPTTAT APFCPSAVSH SVAVPADASP LRKLALFVGP GLLVSVGYMD PGNWATAIEA
GSRFGYALLF VVVLASFSGM LLQSLCSRLG IATGRDLAQL SRERYRPGVA RGQWLLAELS
IVATDLAEVL GAALAFHLLL GVSITTGVVL TAFDTLIVLA LQGANFRRLE AIVLGLIATI
GACFFVELVL IGPYWPDVAA GLRPSWDTLS SQEPLYLAIG ILGATVMPHN LYLHSSVVQT
RVSGDDAASK RSAIRFSRLD TIGSLSLALL VNAAILILAA AAFHGSGHTE VVEIQDAYHL
LDPLVGGALA SFLFGFALLA AGQSSTFTGT IAGQVVMEGF LRAKIPCWQR RLITRGLALV
PALIGVLWLG EAAVGKLLVL SQVVLSLQLP FALWPLIRFS SDRGLMGEFV NPRWVSALAW
SLFGLISAAN LTLLYFWFG
