MNTH2_PSEAE
ID MNTH2_PSEAE Reviewed; 438 AA.
AC Q9RPF2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 08-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Divalent metal cation transporter MntH 2 {ECO:0000255|HAMAP-Rule:MF_00221};
GN Name=mntH2 {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=PA0809;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 47053 / PAO1024 / MM2002;
RX PubMed=10844693; DOI=10.1046/j.1365-2958.2000.01922.x;
RA Kehres D.G., Zaharik M.L., Finlay B.B., Maguire M.E.;
RT "The NRAMP proteins of Salmonella typhimurium and Escherichia coli are
RT selective manganese transporters involved in the response to reactive
RT oxygen.";
RL Mol. Microbiol. 36:1085-1100(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
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DR EMBL; AF161320; AAD46619.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04198.1; -; Genomic_DNA.
DR PIR; A83544; A83544.
DR RefSeq; NP_249500.1; NC_002516.2.
DR RefSeq; WP_003114200.1; NZ_QZGE01000007.1.
DR AlphaFoldDB; Q9RPF2; -.
DR SMR; Q9RPF2; -.
DR STRING; 287.DR97_1173; -.
DR PaxDb; Q9RPF2; -.
DR PRIDE; Q9RPF2; -.
DR EnsemblBacteria; AAG04198; AAG04198; PA0809.
DR GeneID; 877623; -.
DR KEGG; pae:PA0809; -.
DR PATRIC; fig|208964.12.peg.842; -.
DR PseudoCAP; PA0809; -.
DR HOGENOM; CLU_020088_2_0_6; -.
DR InParanoid; Q9RPF2; -.
DR OMA; IATFVNS; -.
DR PhylomeDB; Q9RPF2; -.
DR BioCyc; PAER208964:G1FZ6-823-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071281; P:cellular response to iron ion; IBA:GO_Central.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..438
FT /note="Divalent metal cation transporter MntH 2"
FT /id="PRO_0000212629"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 250
FT /note="K -> Q (in Ref. 1; AAD46619)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 46380 MW; 12F4D54FCD3DFC10 CRC64;
MSAKDTPAPQ AAEPGRAQPV EVPGGGHWWR RLLAFAGPGY LVAVGYMDPG NWATDVAGGA
QLGYLLLSVI LLSSLMAMLL QALSARLGIA SGLDLAQACR ERYSPSTCRL LWLACETAII
ACDLAEVIGT AIALKLLFGL PLAWGALLCV GDALLVLVLI GRGQRPLEAF VVALLTLIFA
CFAVQLLLSR PELGEVLQGF LPSPRVLSDP AALYLAIGIV GATVMPHNLY LHSSLVQSRA
YPRSLAGKRK ALRWAVADSS LALTLALLVN AAILIVAASV FHRNGHTEVV DIEQAHALLS
PLLGLELASL LFAVALLASG LNSTVTTTLA GQIVMEGFLR LRLAPWARRL LTRGVAVLPV
LLVTLLYGED GTARLLIFSQ VILSMQLPLA VIPLLQFVSD RRLMGPLAIG AGTRWLAWAV
ALAIVGLNLQ LLADFAFG
