ID   MNTH_AERHH              Reviewed;         407 AA.
AC   A0KG66;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 2.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=AHA_0709;
OS   Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC
OS   13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=380703;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC
RC   2358 / NCIMB 9240 / NCTC 8049;
RX   PubMed=16980456; DOI=10.1128/jb.00621-06;
RA   Seshadri R., Joseph S.W., Chopra A.K., Sha J., Shaw J., Graf J., Haft D.H.,
RA   Wu M., Ren Q., Rosovitz M.J., Madupu R., Tallon L., Kim M., Jin S.,
RA   Vuong H., Stine O.C., Ali A., Horneman A.J., Heidelberg J.F.;
RT   "Genome sequence of Aeromonas hydrophila ATCC 7966T: jack of all trades.";
RL   J. Bacteriol. 188:8272-8282(2006).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00221}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK37452.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000462; ABK37452.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_016349448.1; NC_008570.1.
DR   RefSeq; YP_855251.1; NC_008570.1.
DR   AlphaFoldDB; A0KG66; -.
DR   SMR; A0KG66; -.
DR   STRING; 380703.AHA_0709; -.
DR   EnsemblBacteria; ABK37452; ABK37452; AHA_0709.
DR   GeneID; 58197734; -.
DR   GeneID; 64357164; -.
DR   KEGG; aha:AHA_0709; -.
DR   PATRIC; fig|380703.7.peg.711; -.
DR   eggNOG; COG1914; Bacteria.
DR   HOGENOM; CLU_020088_2_0_6; -.
DR   Proteomes; UP000000756; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..407
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000325600"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        193..213
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   407 AA;  43101 MW;  200FDE32F0D101F0 CRC64;
     MQPALTTAIP ARKFKLTLLG PAFIAAIGYI DPGNFATNIQ AGSTFGYQLL WVVVWANLMA
     MLVQTLSAKL GIVTGKNLAE HIRDRLPKPA VWAYWVQAEI IAMATDLAEF IGAAVGFKLL
     LGVTLLEGAG ITAVVTWGIL MLQSRGQKPL EFVVGGLLLF VAAAYIVELV FSRPHLPSLL
     EGALFPGLPN SDAVYLAAGV LGATVMPHVI YLHSALTQHT QDQGSVPQRL HTTRVDVAIA
     MTIAGFVNLA MMAMAAAAFH SSGNQQVAEL ESAYQTLTPL LGQAAATLFG LSLVASGISS
     TVVGTLAGQV VMQGFVRFTI PLWLRRAITM APAFVVIAMG LNTTEILVLS QVVLSFGIAL
     ALIPLLILTG DRALMGEYRN HPVTQAVGRL IVALVIGLNA YLLVAMI