MNTH_BACSU
ID MNTH_BACSU Reviewed; 425 AA.
AC P96593;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; Synonyms=ydaR;
GN OrderedLocusNames=BSU04360;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RA Kasahara Y., Nakai S., Lee S., Sadaie Y., Ogasawara N.;
RT "A 148 kbp sequence of the region between 35 and 47 degree of the Bacillus
RT subtilis genome.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION IN MANGANESE UPTAKE, INDUCTION, AND GENE NAME.
RC STRAIN=168;
RX PubMed=10760146; DOI=10.1046/j.1365-2958.2000.01811.x;
RA Que Q., Helmann J.D.;
RT "Manganese homeostasis in Bacillus subtilis is regulated by MntR, a
RT bifunctional regulator related to the diphtheria toxin repressor family of
RT proteins.";
RL Mol. Microbiol. 35:1454-1468(2000).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC Involved in manganese uptake. Can probably also transport cadmium,
CC cobalt, copper and zinc, but not iron. May be the predominant
CC transporter of manganese during logarithmic phase growth.
CC {ECO:0000255|HAMAP-Rule:MF_00221, ECO:0000269|PubMed:10760146}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Repressed by MntR in the presence of manganese.
CC {ECO:0000269|PubMed:10760146}.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
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DR EMBL; AB001488; BAA19273.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12243.1; -; Genomic_DNA.
DR PIR; A69770; A69770.
DR RefSeq; NP_388317.1; NC_000964.3.
DR RefSeq; WP_003234364.1; NZ_JNCM01000031.1.
DR AlphaFoldDB; P96593; -.
DR SMR; P96593; -.
DR IntAct; P96593; 4.
DR STRING; 224308.BSU04360; -.
DR TCDB; 2.A.55.3.3; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR PaxDb; P96593; -.
DR PRIDE; P96593; -.
DR EnsemblBacteria; CAB12243; CAB12243; BSU_04360.
DR GeneID; 938241; -.
DR KEGG; bsu:BSU04360; -.
DR PATRIC; fig|224308.179.peg.462; -.
DR eggNOG; COG1914; Bacteria.
DR InParanoid; P96593; -.
DR OMA; IATFVNS; -.
DR PhylomeDB; P96593; -.
DR BioCyc; BSUB:BSU04360-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071281; P:cellular response to iron ion; IBA:GO_Central.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Ion transport; Manganese; Membrane; Reference proteome;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..425
FT /note="Divalent metal cation transporter MntH"
FT /id="PRO_0000212611"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 401..421
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ SEQUENCE 425 AA; 45686 MW; 45F099720608FBA0 CRC64;
MMNKDITAQS PRSKAVQDAL DGKIRGFRGL LPFLGPAFIA AIAYIDPGNF ATNISAGSKY
GYMLLWVILF SNIMALLIQS LSAKLGIATG KNLPEVAREE FPKPVSIGLW IQGELVIIAT
DLAEFIGAAL GLYLLFGIPM LEASIIAAIG SFAILELQRR GYRSLEAGIA GMLFVVVIAF
ALQTFFAKPD AVSVMKGLFV PAFHGTDSVL LAAGILGATV MPHAIYLHSA LTQRRVVGKT
DAERKKIFRF EFIDILIAML IAGAINASML IVAAALFFKN GLFVEDLDVA FQQFGHLVSP
MSAALFGIGL LVAGLSSSSV GTLSGDVIMQ GFINYRIPLY VRRFITIIPP ILIIASGVNP
TTALVLSQVV LSFGIAFALI PLIMFTSNKR IMGSLINAKW ITVVSWLIAV LIVALNVFLI
VDTFR
