ID   MNTH_BRADU              Reviewed;         450 AA.
AC   Q89K67;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=bll5044;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00221}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
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DR   EMBL; BA000040; BAC50309.1; -; Genomic_DNA.
DR   RefSeq; NP_771684.1; NC_004463.1.
DR   RefSeq; WP_011087805.1; NZ_CP011360.1.
DR   AlphaFoldDB; Q89K67; -.
DR   SMR; Q89K67; -.
DR   STRING; 224911.27353309; -.
DR   TCDB; 2.A.55.2.6; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR   EnsemblBacteria; BAC50309; BAC50309; BAC50309.
DR   GeneID; 64024807; -.
DR   KEGG; bja:bll5044; -.
DR   PATRIC; fig|224911.44.peg.4909; -.
DR   eggNOG; COG1914; Bacteria.
DR   HOGENOM; CLU_020088_2_0_5; -.
DR   InParanoid; Q89K67; -.
DR   OMA; IATFVNS; -.
DR   PhylomeDB; Q89K67; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071281; P:cellular response to iron ion; EXP:CollecTF.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..450
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000212612"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   450 AA;  47926 MW;  ADE9C1EF3A2FBE86 CRC64;
     MDARSPDLTT DAAGWRTDVP TTKSLAEVNA SVALPTAGVW WRRLLAFVGP GYLVSVGYMD
     PGNWATDLAG GSKFGYTLLS VILLSNLMAI LLQSLAARLG IVTDRDLAQA CRATYSPAVN
     FLLWLACEAA IIACDLAEVI GTAIALKLLF GIPLIGGALI AALDAFLLLL LMNRGFRFLE
     AFVIALLAVI AVCFAVQIVA AAPPVAEVLH GFMPKSEIFT NPEMLYIAIG IIGATVMPHN
     LYLHSSIVQT RAYERNETGR REAIKWATTD STIALMLALF INAAILVVAA ATFHKSGHSD
     VAEIGQAFEL LSPLLGLGIA STLFAIALLA SGLNSTVTAT LAGQIVMEGF LDLRLPSWAR
     RLLTRGIAII PVIIVTAIYG ERGTADLLVF SQVVLSMQLP FAVIPLVRFV SDRRKMGKFA
     ISPYVAAIAW IVAGVIVVLN LKLLADTLLG