ID   MNTH_BRUME              Reviewed;         456 AA.
AC   P65544; Q8YI76;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=BMEI0569;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00221}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
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DR   EMBL; AE008917; AAL51750.1; -; Genomic_DNA.
DR   PIR; AC3323; AC3323.
DR   RefSeq; WP_002964549.1; NZ_GG703780.1.
DR   AlphaFoldDB; P65544; -.
DR   SMR; P65544; -.
DR   STRING; 224914.BMEI0569; -.
DR   EnsemblBacteria; AAL51750; AAL51750; BMEI0569.
DR   GeneID; 45052451; -.
DR   GeneID; 55591092; -.
DR   KEGG; bme:BMEI0569; -.
DR   eggNOG; COG1914; Bacteria.
DR   OMA; IATFVNS; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane; Symport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000212613"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   456 AA;  49027 MW;  5D23C4767EB992CB CRC64;
     MVPHGSCPSG AREVTFEGWR RERGEASMSD VHRTIRVNRS GSKFRRALSF FGPGYLVAVG
     YMDPGNWATS LAGGSRFGYA LLSVVLLSNL MAVLLQALCT RLAVATGRDL AQACRDAYPR
     FLAWPLWLLA ELAICATDLA EVIGTAIGLN LLFGIPLEIG VILTAVDVLL VLYLQNKGFR
     RVEALIITLL GVIALCFLTQ IIMAQPQWGE VIKGFAPTTE IVSNPDMLYI ALGIIGATVM
     PHNLYLHSGI VQTRDYGHTT AEKREAIRYA TLDSTIALTF ALVINASILI LAAASFHATG
     HTGVEDLDKA HALLNPLLGS AIAPALFAIA LLCCGLNSTI TATMAGQIVM EGFIDIRLKP
     WIRRAITRFV AIVPAAIVTI LYGSQGTTEL LILSQVVLSL QLPFAVIPLV IFTAQKKKMG
     SLAAAPWVTF LAAITAAIIV VLNLKLIYDF FTGAPI