ID   MNTH_CLOAB              Reviewed;         431 AA.
AC   Q97TN5;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=CA_P0063;
OS   Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS   / VKM B-1787).
OG   Plasmid pSOL1.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=272562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787;
RX   PubMed=11466286; DOI=10.1128/jb.183.16.4823-4838.2001;
RA   Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA   Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA   Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA   Smith D.R.;
RT   "Genome sequence and comparative analysis of the solvent-producing
RT   bacterium Clostridium acetobutylicum.";
RL   J. Bacteriol. 183:4823-4838(2001).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00221};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
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DR   EMBL; AE001438; AAK76809.1; -; Genomic_DNA.
DR   RefSeq; NP_149227.1; NC_001988.2.
DR   RefSeq; WP_010890748.1; NC_001988.2.
DR   AlphaFoldDB; Q97TN5; -.
DR   SMR; Q97TN5; -.
DR   EnsemblBacteria; AAK76809; AAK76809; CA_P0063.
DR   GeneID; 45000295; -.
DR   KEGG; cac:CA_P0063; -.
DR   PATRIC; fig|272562.8.peg.63; -.
DR   HOGENOM; CLU_020088_2_0_9; -.
DR   OMA; IATFVNS; -.
DR   OrthoDB; 416257at2; -.
DR   Proteomes; UP000000814; Plasmid pSOL1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Membrane; Plasmid; Reference proteome;
KW   Symport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..431
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000212615"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        347..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   431 AA;  47026 MW;  C44D77DDFD5028E9 CRC64;
     MDKLSIREDN YNIKHKTISL NRASSVTRNL KGLLKFLGPA FVVSVAYIDP GNFATNISGG
     SSFNYNLIWV ILWSNLMAIF LQTMSAKLGI ATGCSLPEMC AKVFSKRANW IFWIVGELGA
     MATDLAEFIG GTLGLYLLFR IPMIYAGLLT GVLTFIIVYM EKYGQKMVET IIAALIAVIC
     VAYTIELFLA RPAWTQVGMH TLIPSLPNGE AVLIAVGMLG ATVMPHVIYL HSELVQHRNT
     NSSDKEKLHH LKMEKIDILI AMNIAFVVNA AMVIVSAAVF FKHGIKVSTI EEAHRSLQPL
     LGNLSSGAFG IALLASGLSS SAVGTMAGQT IMKGFVNLSI PINLRRIITM LPALIIIALG
     INPMRVLVLS QVALSFILPF PIIQMLLIAG RKDLMGILVN KKFTKIVGFI IATMIILLNI
     ILLYLTFTGQ T