MNTH_DEIRA
ID MNTH_DEIRA Reviewed; 436 AA.
AC Q9RTP8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=DR_1709;
OS Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC Deinococcus.
OX NCBI_TaxID=243230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC 9279 / R1 / VKM B-1422;
RX PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA Fraser C.M.;
RT "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT R1.";
RL Science 286:1571-1577(1999).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00221};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
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DR EMBL; AE000513; AAF11265.1; -; Genomic_DNA.
DR PIR; G75363; G75363.
DR RefSeq; NP_295432.1; NC_001263.1.
DR RefSeq; WP_010888344.1; NZ_CP015081.1.
DR PDB; 5KTE; X-ray; 3.94 A; A=26-436.
DR PDB; 6BU5; X-ray; 2.40 A; A=35-436.
DR PDB; 6C3I; X-ray; 2.95 A; A/B=1-436.
DR PDB; 6D91; X-ray; 2.36 A; A=35-436.
DR PDB; 6D9W; X-ray; 3.94 A; A=26-436.
DR PDBsum; 5KTE; -.
DR PDBsum; 6BU5; -.
DR PDBsum; 6C3I; -.
DR PDBsum; 6D91; -.
DR PDBsum; 6D9W; -.
DR AlphaFoldDB; Q9RTP8; -.
DR SMR; Q9RTP8; -.
DR STRING; 243230.DR_1709; -.
DR TCDB; 2.A.55.3.7; the metal ion (mn(2+)-iron) transporter (nramp) family.
DR ABCD; Q9RTP8; 1 sequenced antibody.
DR EnsemblBacteria; AAF11265; AAF11265; DR_1709.
DR KEGG; dra:DR_1709; -.
DR PATRIC; fig|243230.17.peg.1920; -.
DR eggNOG; COG1914; Bacteria.
DR HOGENOM; CLU_020088_2_0_0; -.
DR InParanoid; Q9RTP8; -.
DR OMA; IATFVNS; -.
DR OrthoDB; 416257at2; -.
DR Proteomes; UP000002524; Chromosome I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071281; P:cellular response to iron ion; IBA:GO_Central.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..436
FT /note="Divalent metal cation transporter MntH"
FT /id="PRO_0000212616"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 411..431
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 44..51
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 52..55
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 57..70
FT /evidence="ECO:0007829|PDB:6D91"
FT TURN 71..74
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 75..99
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 103..110
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 113..146
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 150..163
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 166..169
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 173..197
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 201..206
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 217..226
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 231..241
FT /evidence="ECO:0007829|PDB:6D91"
FT STRAND 248..250
FT /evidence="ECO:0007829|PDB:6BU5"
FT HELIX 251..286
FT /evidence="ECO:0007829|PDB:6D91"
FT TURN 287..290
FT /evidence="ECO:0007829|PDB:6D91"
FT TURN 292..295
FT /evidence="ECO:0007829|PDB:6C3I"
FT HELIX 297..307
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 310..342
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 349..366
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 370..395
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 399..402
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 403..405
FT /evidence="ECO:0007829|PDB:6D91"
FT HELIX 409..434
FT /evidence="ECO:0007829|PDB:6D91"
SQ SEQUENCE 436 AA; 46652 MW; 98776EF8B19103FA CRC64;
MDSRSPSLPD DRPDPPEQHL DARAGATLRG TAGPRGVRRI LPFLGPAVIA SIAYMDPGNF
ATNIEGGARY GYSLLWVILA ANLMAMVIQN LSANLGIASG RNLPELIRER WPRPLVWFYW
IQAELVAMAT DLAEFLGAAL AIQLLTGLPM FWGAVVTGVV TFWLLNLQKR GTRPLELAVG
AFVLMIGVAY LVQVVLARPD LAAVGAGFVP RLQGPGSAYL AVGIIGATVM PHVIYLHSAL
TQGRIQTDTT EEKRRLVRLN RVDVIAAMGL AGLINMSMLA VAAATFHGKN VENAGDLTTA
YQTLTPLLGP AASVLFAVAL LASGLSSSAV GTMAGDVIMQ GFMGFHIPLW LRRLITMLPA
FIVILLGMDP SSVLILSQVI LCFGVPFALV PLLLFTARRD VMGALVTRRS FTVIGWVIAV
IIIALNGYLL WELLGG
