MNTH_LACPL
ID MNTH_LACPL Reviewed; 464 AA.
AC Q8GH68; F9UTN2;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; Synonyms=mntH1;
GN OrderedLocusNames=lp_0275;
OS Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS (Lactobacillus plantarum).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactiplantibacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nierop Groot M.N., Pentcheva E., Verdoes J.C., Klaassens E., de Vos W.M.,
RA Delcour J., Kleerebezem M., Hols P.;
RT "Identification and transcriptional analysis of an ABC-transporter and two
RT Nramp type transporters that are induced upon manganese starvation in
RT Lactobacillus plantarum.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=22156394; DOI=10.1128/jb.06275-11;
RA Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA Kleerebezem M., van Hijum S.A.;
RT "Complete resequencing and reannotation of the Lactobacillus plantarum
RT WCFS1 genome.";
RL J. Bacteriol. 194:195-196(2012).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00221};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF416709; AAO15439.1; -; Genomic_DNA.
DR EMBL; AL935263; CCC77802.1; -; Genomic_DNA.
DR RefSeq; YP_004888316.1; NC_004567.2.
DR AlphaFoldDB; Q8GH68; -.
DR SMR; Q8GH68; -.
DR STRING; 220668.lp_0275; -.
DR EnsemblBacteria; CCC77802; CCC77802; lp_0275.
DR KEGG; lpl:lp_0275; -.
DR PATRIC; fig|220668.9.peg.229; -.
DR eggNOG; COG1914; Bacteria.
DR HOGENOM; CLU_020088_2_0_9; -.
DR OMA; SPKWLRY; -.
DR PhylomeDB; Q8GH68; -.
DR BioCyc; LPLA220668:G1GW0-224-MON; -.
DR Proteomes; UP000000432; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..464
FT /note="Divalent metal cation transporter MntH"
FT /id="PRO_0000212621"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 464 AA; 50352 MW; ACFFE2C06CD51FAB CRC64;
MKSAKTKDHA KMKAAEEKAI HSTGADSKSL DEVNGSVRVP KDASFWRTLI AYTGPGALVA
VGYMDPGNWI TSIAGGSQYK YALLSVILLS SLIAMLLQAM AARLGIVTGK DLAQLTRERT
SKGMGIFLWI ITELAIMATD VAEIIGSGIA LKLLFGFPLI VGILITTADV LILLLLMKLG
FRKIEAIVAT LVAVILFVFL YEVIISQPNI PEMLKGYVPT SRIVSNRSML FLALGIVGAT
VMPHNLYLGS SISQTRQVDR SDEKEVAKAV KFTTIDSNIQ LSVAFVVNSL LLILGAALFF
GTKGDLGRFV DLYNALGDSK VVGSIASPLL SMLFAIALLS SGQSSTITGT LSGQIIMEGF
IRLKMPLWAQ RLLTRLISVT PVLAFAIYYH GNEAKIEDLL TMSQVFLSIA LPFAMIPLVM
FTSNRALMGN FTNRVWVKWT AWIVTVILII LNIYLILQTV GLVK
