ID   MNTH_LEVBR              Reviewed;         464 AA.
AC   Q93V04;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; Synonyms=hitA;
OS   Levilactobacillus brevis (Lactobacillus brevis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Levilactobacillus.
OX   NCBI_TaxID=1580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
RC   STRAIN=L578Y;
RX   PubMed=11414327; DOI=10.1007/s002530100600;
RA   Hayashi N., Ito M., Horiike S., Taguchi H.;
RT   "Molecular cloning of a putative divalent-cation transporter gene as a new
RT   genetic marker for the identification of Lactobacillus brevis strains
RT   capable of growing in beer.";
RL   Appl. Microbiol. Biotechnol. 55:596-603(2001).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00221};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- INDUCTION: In response to bitter compounds derived from hops.
CC       {ECO:0000269|PubMed:11414327}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
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DR   EMBL; AB035808; BAB47552.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q93V04; -.
DR   SMR; Q93V04; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Ion transport; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..464
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000212620"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        376..396
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        399..419
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   464 AA;  50458 MW;  C797E1825CE48F19 CRC64;
     MKEGIDMRES VAEEPKHKFF QSTEGENKSL DEVNGSVKVP KNAGFWRTLF AYTGPGILIA
     VGYMDPGNWI TSIAGGAQFK YSLLSVILIS SLIAMLLQSM AARLGIVTGK DLAQLTRERT
     SKTMGIILWL ITESAIMATD VAEIIGSGIA IKLLFNIPLV VGILITTADV LILLLLMKLG
     FRKIEAIVAT LVAVILLVFT YEVFLAGPQL DQMFAGYMPT KDIVTNKSML YLALGIVGAT
     VMPHDLYLGS SISQTRAVDR HDRQDVAKAI KFTTIDSNLQ LTIAFIVNSL LLILGAALFF
     GTNSTVGRFV DLFNSLNNSH IVGAIASPML SMLFAVALLS SGQSSTITGT LSGQIIMEGF
     IHLRMPLWAQ RLLTRLLSVT PVLIFAIYYH GNEAKIENLL TLSQVFLSVA LPFAIVPLVK
     FTSSKELMGE FVNKAWVKYS AWVATVVLVS LNIYLILQTV GVIG