MNTH_MYCBO
ID MNTH_MYCBO Reviewed; 684 AA.
AC O69443; A0A1R3XWU1; Q7U106; X2BG74;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Divalent metal cation transporter MntH;
DE AltName: Full=BRAMP;
GN Name=mntH; OrderedLocusNames=BQ2027_MB0948C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 264-678.
RC STRAIN=BCG;
RX PubMed=9632246; DOI=10.1046/j.1365-2958.1998.00790.x;
RA Agranoff D.D., Krishna S.;
RT "Metal ion homeostasis and intracellular parasitism.";
RL Mol. Microbiol. 28:403-412(1998).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NRAMP family.
CC {ECO:0000305}.
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DR EMBL; LT708304; SIT99546.1; -; Genomic_DNA.
DR EMBL; AJ005699; CAA06684.1; -; Genomic_DNA.
DR RefSeq; NP_854605.1; NC_002945.3.
DR RefSeq; WP_010950469.1; NC_002945.4.
DR AlphaFoldDB; O69443; -.
DR SMR; O69443; -.
DR EnsemblBacteria; SIT99546; SIT99546; BQ2027_MB0948C.
DR PATRIC; fig|233413.5.peg.1033; -.
DR OMA; IATFVNS; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.360; -; 1.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR005025; FMN_Rdtase-like.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF03358; FMN_red; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR SUPFAM; SSF52218; SSF52218; 1.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 3: Inferred from homology;
KW Cell membrane; Ion transport; Membrane; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..684
FT /note="Divalent metal cation transporter MntH"
FT /id="PRO_0000212625"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..387
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..446
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..489
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 514..534
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 555..577
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 597..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 621..643
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 656..678
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 223..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 72834 MW; 0C0A99152E755F75 CRC64;
MTTTSDQNAA APPRFDGLRA LFINATLKRS PELSHTDGLI ERSSGIMREH GVQVDTLRAV
DHDIATGVWP DMTEHGWATD EWPALYRRVL DAHILVLCGP IWLGDNSSVM KRVIERLYAC
SSLLNEDGQY AYYGRAGGCL ITGNEDGVKH CAMNVLYSLQ HLGYTIPPQA DAGWIGEAGP
GPSYLDPGSG GPENDFTNRN TTFMTFNLMH IAQMLRAPAA SRPTAINAPS GTPAAGRTSP
TPTTDSQRRS RVARWLVAGE FRLLSHLCSR GSKVGELAQD TRTSLKTSWY LLGPAFVAAI
AYVDPGNVAA NVSSGAQFGY LLLWVIVAAN VMAALVQYLS AKLGLVTGRS LPEAIGKRMG
RPARLAYWAQ AEIVAMATDV AEVIGGAIAL RIMFNLPLPI GGIITGVVSL LLLTIQDRRG
QRLFERVITA LLLVIAIGFT ASFFVVTPPP NAVLGGLAPR FQGTESVLLA AAIMGATVMP
HAVYLHSGLA RDRHGHPDPG PQRRRLLRVT RWDVGLAMLI AGGVNAAMLL VAALNMRGRG
DTASIEGAYH AVHDTLGATI AVLFAVGLLA SGLASSSVGA YAGAMIMQGL LHWSVPMLVR
RLITLGPALA ILTLGFDPTR TLVLSQVVLS FGIPFAVLPL VKLTGSPAVM GGDTNHRATT
WVGWVVAVMV SLLNVMLIYL TVTG
