ID   MNTH_MYCTO              Reviewed;         428 AA.
AC   P9WIZ4; L0T844; O05916;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
DE   AltName: Full=Mramp;
GN   Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221}; OrderedLocusNames=MT0951;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC       Transports zinc and iron. Can also interact with manganese and copper
CC       (By similarity). {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00221};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00221}.
CC   -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC       Rule:MF_00221}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK45198.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK45198.1; ALT_INIT; Genomic_DNA.
DR   PIR; D70583; D70583.
DR   RefSeq; WP_003898649.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WIZ4; -.
DR   SMR; P9WIZ4; -.
DR   EnsemblBacteria; AAK45198; AAK45198; MT0951.
DR   KEGG; mtc:MT0951; -.
DR   PATRIC; fig|83331.31.peg.1021; -.
DR   HOGENOM; CLU_020088_2_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00221; NRAMP; 1.
DR   InterPro; IPR001046; NRAMP_fam.
DR   PANTHER; PTHR11706; PTHR11706; 1.
DR   Pfam; PF01566; Nramp; 1.
DR   PRINTS; PR00447; NATRESASSCMP.
DR   TIGRFAMs; TIGR01197; nramp; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Iron; Membrane; Symport; Transmembrane;
KW   Transmembrane helix; Transport; Zinc.
FT   CHAIN           1..428
FT                   /note="Divalent metal cation transporter MntH"
FT                   /id="PRO_0000427919"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        334..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
SQ   SEQUENCE   428 AA;  45004 MW;  D90CF98756715CD8 CRC64;
     MAGEFRLLSH LCSRGSKVGE LAQDTRTSLK TSWYLLGPAF VAAIAYVDPG NVAANVSSGA
     QFGYLLLWVI VAANVMAALV QYLSAKLGLV TGRSLPEAIG KRMGRPARLA YWAQAEIVAM
     ATDVAEVIGG AIALRIMFNL PLPIGGIITG VVSLLLLTIQ DRRGQRLFER VITALLLVIA
     IGFTASFFVV TPPPNAVLGG LAPRFQGTES VLLAAAIMGA TVMPHAVYLH SGLARDRHGH
     PDPGPQRRRL LRVTRWDVGL AMLIAGGVNA AMLLVAALNM RGRGDTASIE GAYHAVHDTL
     GATIAVLFAV GLLASGLASS SVGAYAGAMI MQGLLHWSVP MLVRRLITLG PALAILTLGF
     DPTRTLVLSQ VVLSFGIPFA VLPLVKLTGS PAVMGGDTNH RATTWVGWVV AVMVSLLNVM
     LIYLTVTG