MNTH_YERPE
ID MNTH_YERPE Reviewed; 409 AA.
AC Q8ZCK2; Q0WCT2;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Divalent metal cation transporter MntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN Name=mntH {ECO:0000255|HAMAP-Rule:MF_00221};
GN OrderedLocusNames=YPO2982, y1500, YP_2607;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000255|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00221}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000255|HAMAP-
CC Rule:MF_00221}.
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DR EMBL; AL590842; CAL21586.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM85071.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS62800.1; -; Genomic_DNA.
DR PIR; AG0362; AG0362.
DR RefSeq; WP_002211621.1; NZ_WUCM01000029.1.
DR RefSeq; YP_002347906.1; NC_003143.1.
DR AlphaFoldDB; Q8ZCK2; -.
DR SMR; Q8ZCK2; -.
DR IntAct; Q8ZCK2; 4.
DR STRING; 214092.YPO2982; -.
DR PaxDb; Q8ZCK2; -.
DR DNASU; 1146447; -.
DR EnsemblBacteria; AAM85071; AAM85071; y1500.
DR EnsemblBacteria; AAS62800; AAS62800; YP_2607.
DR GeneID; 66844874; -.
DR KEGG; ype:YPO2982; -.
DR KEGG; ypk:y1500; -.
DR KEGG; ypm:YP_2607; -.
DR PATRIC; fig|214092.21.peg.3436; -.
DR eggNOG; COG1914; Bacteria.
DR HOGENOM; CLU_020088_2_0_6; -.
DR OMA; IATFVNS; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015086; F:cadmium ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071281; P:cellular response to iron ion; EXP:CollecTF.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR PANTHER; PTHR11706; PTHR11706; 1.
DR Pfam; PF01566; Nramp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR TIGRFAMs; TIGR01197; nramp; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..409
FT /note="Divalent metal cation transporter MntH"
FT /id="PRO_0000212647"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00221"
FT CONFLICT 153
FT /note="L -> P (in Ref. 3; AAS62800)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 409 AA; 43742 MW; 1E9963848CAF877D CRC64;
MLNGRAVDTS RRPLRKIKLS LMGPAFIAAI AYIDPGNFAT NIQAGATFGY TLLWVVVWAN
VMAMLVQLLS AKLGIATGKN LAEHIRDRFP RPVVWAYWVQ AEIIVMATDL AEFIGAAIGF
KLLFGVTLLQ GAVLTGIATF LILMLQNRGQ KPLELVIGGL LLFVAAAYIV ELIFSQPDIA
ALGRGMLIPN LPDGNAVFLA AGVLGATIMP HVIYLHSALT QTGGEESKTE RYASTKFDVA
IAMTIAGFVN LAMMATAAAA FHFNGYENIA EIEEAYITLQ PLLGNAAATV FGLSLIAAGL
SSTVVGTLAG QVVMQGFVRF YIPMWVRRIV TMLPSFIVIL AGMDATQILV MSQVLLSFGI
ALALVPLLVF TGNKELMGEL VDTKTTQILG KLVVLIVVGL NAYLLISLL
