ID   MNTP2_CLOBH             Reviewed;         201 AA.
AC   A5I1C7; A7G329;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Putative manganese efflux pump MntP 2 {ECO:0000255|HAMAP-Rule:MF_01521};
GN   Name=mntP2 {ECO:0000255|HAMAP-Rule:MF_01521};
GN   OrderedLocusNames=CBO1290, CLC_1328;
OS   Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=441771;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX   PubMed=17519437; DOI=10.1101/gr.6282807;
RA   Sebaihia M., Peck M.W., Minton N.P., Thomson N.R., Holden M.T.G.,
RA   Mitchell W.J., Carter A.T., Bentley S.D., Mason D.R., Crossman L.,
RA   Paul C.J., Ivens A., Wells-Bennik M.H.J., Davis I.J., Cerdeno-Tarraga A.M.,
RA   Churcher C., Quail M.A., Chillingworth T., Feltwell T., Fraser A.,
RA   Goodhead I., Hance Z., Jagels K., Larke N., Maddison M., Moule S.,
RA   Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA   White B., Whithead S., Parkhill J.;
RT   "Genome sequence of a proteolytic (Group I) Clostridium botulinum strain
RT   Hall A and comparative analysis of the clostridial genomes.";
RL   Genome Res. 17:1082-1092(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hall / ATCC 3502 / NCTC 13319 / Type A;
RX   PubMed=18060065; DOI=10.1371/journal.pone.0001271;
RA   Smith T.J., Hill K.K., Foley B.T., Detter J.C., Munk A.C., Bruce D.C.,
RA   Doggett N.A., Smith L.A., Marks J.D., Xie G., Brettin T.S.;
RT   "Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4
RT   and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within
RT   plasmids.";
RL   PLoS ONE 2:E1271-E1271(2007).
CC   -!- FUNCTION: Probably functions as a manganese efflux pump.
CC       {ECO:0000255|HAMAP-Rule:MF_01521}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01521};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01521}.
CC   -!- SIMILARITY: Belongs to the MntP (TC 9.B.29) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01521}.
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DR   EMBL; CP000727; ABS38815.1; -; Genomic_DNA.
DR   EMBL; AM412317; CAL82839.1; -; Genomic_DNA.
DR   RefSeq; WP_011948910.1; NC_009698.1.
DR   RefSeq; YP_001253812.1; NC_009495.1.
DR   RefSeq; YP_001387194.1; NC_009698.1.
DR   AlphaFoldDB; A5I1C7; -.
DR   GeneID; 5185545; -.
DR   KEGG; cbh:CLC_1328; -.
DR   KEGG; cbo:CBO1290; -.
DR   PATRIC; fig|413999.7.peg.1276; -.
DR   HOGENOM; CLU_096410_3_0_9; -.
DR   OMA; NKEREFA; -.
DR   PRO; PR:A5I1C7; -.
DR   Proteomes; UP000001986; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01521; MntP_pump; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR003810; Mntp/YtaF.
DR   InterPro; IPR022929; Put_MntP.
DR   PANTHER; PTHR35529; PTHR35529; 1.
DR   Pfam; PF02659; Mntp; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Ion transport; Manganese; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..201
FT                   /note="Putative manganese efflux pump MntP 2"
FT                   /id="PRO_0000315563"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
SQ   SEQUENCE   201 AA;  21655 MW;  8636396F3F51FC3B CRC64;
     MDLISVILIS IGLSMDAFAV SITNGAMISK VTASEGIRIG LFFGGFQALM PLIGWSIGIK
     FESYIAALDH WIALILLSII GGKMIYDSVK ENQDHKDEIA CDYAAGEKKC LNNKTLILLA
     IATSIDALAV GVSFAFLKVS IINTIIIIGS ITFVICFIGV MIGKKCGKLL KKRAEILGGV
     VLILIGVKIF IQHTNILSYI F