ID   MNTP_ECOLI              Reviewed;         188 AA.
AC   P76264; O07974;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2004, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Probable manganese efflux pump MntP {ECO:0000255|HAMAP-Rule:MF_01521};
GN   Name=mntP {ECO:0000255|HAMAP-Rule:MF_01521}; Synonyms=yebN;
GN   OrderedLocusNames=b1821, JW5830;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA   Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA   Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA   Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA   Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA   Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C., Yamamoto Y.,
RA   Horiuchi T.;
RT   "A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 40.1-50.0 min region on the linkage map.";
RL   DNA Res. 3:379-392(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-53.
RX   PubMed=8107138; DOI=10.1006/jmbi.1994.1163;
RA   Stojiljkovic I., Baumler A.J., Hantke K.;
RT   "Fur regulon in Gram-negative bacteria. Identification and characterization
RT   of new iron-regulated Escherichia coli genes by a fur titration assay.";
RL   J. Mol. Biol. 236:531-545(1994).
RN   [5]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [6]
RP   FUNCTION IN MANGANESE HOMEOSTASIS, INDUCTION, DISRUPTION PHENOTYPE, AND
RP   GENE NAME.
RX   PubMed=21908668; DOI=10.1128/jb.05872-11;
RA   Waters L.S., Sandoval M., Storz G.;
RT   "The Escherichia coli MntR miniregulon includes genes encoding a small
RT   protein and an efflux pump required for manganese homeostasis.";
RL   J. Bacteriol. 193:5887-5897(2011).
CC   -!- FUNCTION: Probably functions as a manganese efflux pump.
CC       {ECO:0000255|HAMAP-Rule:MF_01521, ECO:0000269|PubMed:21908668}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- INDUCTION: Up-regulated by MntR in response to manganese.
CC       {ECO:0000269|PubMed:21908668}.
CC   -!- DISRUPTION PHENOTYPE: Deletion causes manganese sensitivity and leads
CC       to increased intracellular manganese levels.
CC       {ECO:0000269|PubMed:21908668}.
CC   -!- SIMILARITY: Belongs to the MntP (TC 9.B.29) family. {ECO:0000255|HAMAP-
CC       Rule:MF_01521}.
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DR   EMBL; U00096; AAC74891.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAA15632.2; -; Genomic_DNA.
DR   EMBL; X75948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; E64943; E64943.
DR   RefSeq; NP_416335.4; NC_000913.3.
DR   RefSeq; WP_001296134.1; NZ_STEB01000009.1.
DR   AlphaFoldDB; P76264; -.
DR   BioGRID; 4263026; 7.
DR   STRING; 511145.b1821; -.
DR   TCDB; 2.A.107.1.1; the mntp mn(2+) exporter (mntp) family.
DR   jPOST; P76264; -.
DR   PaxDb; P76264; -.
DR   PRIDE; P76264; -.
DR   EnsemblBacteria; AAC74891; AAC74891; b1821.
DR   EnsemblBacteria; BAA15632; BAA15632; BAA15632.
DR   GeneID; 66674290; -.
DR   GeneID; 946341; -.
DR   KEGG; ecj:JW5830; -.
DR   KEGG; eco:b1821; -.
DR   PATRIC; fig|511145.12.peg.1898; -.
DR   EchoBASE; EB3768; -.
DR   eggNOG; COG1971; Bacteria.
DR   HOGENOM; CLU_096410_0_0_6; -.
DR   InParanoid; P76264; -.
DR   OMA; WHFGLFQ; -.
DR   PhylomeDB; P76264; -.
DR   BioCyc; EcoCyc:G6999-MON; -.
DR   BioCyc; MetaCyc:G6999-MON; -.
DR   PRO; PR:P76264; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IMP:EcoCyc.
DR   GO; GO:0071421; P:manganese ion transmembrane transport; IMP:EcoCyc.
DR   GO; GO:0010042; P:response to manganese ion; IEP:EcoCyc.
DR   HAMAP; MF_01521; MntP_pump; 1.
DR   InterPro; IPR003810; Mntp/YtaF.
DR   InterPro; IPR022929; Put_MntP.
DR   PANTHER; PTHR35529; PTHR35529; 1.
DR   Pfam; PF02659; Mntp; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Ion transport; Manganese; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..188
FT                   /note="Probable manganese efflux pump MntP"
FT                   /id="PRO_0000155649"
FT   TOPO_DOM        1..2
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TOPO_DOM        24..65
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TOPO_DOM        87..105
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TOPO_DOM        129..142
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TOPO_DOM        164..167
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01521"
FT   TOPO_DOM        188
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   188 AA;  20117 MW;  09BBB5C3D6185A9B CRC64;
     MNITATVLLA FGMSMDAFAA SIGKGATLHK PKFSEALRTG LIFGAVETLT PLIGWGMGML
     ASRFVLEWNH WIAFVLLIFL GGRMIIEGFR GADDEDEEPR RRHGFWLLVT TAIATSLDAM
     AVGVGLAFLQ VNIIATALAI GCATLIMSTL GMMVGRFIGS IIGKKAEILG GLVLIGIGVQ
     ILWTHFHG