ID   MNTR_ECO57              Reviewed;         155 AA.
AC   Q8X7U4;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Transcriptional regulator MntR;
DE   AltName: Full=Manganese transport regulator;
GN   Name=mntR; OrderedLocusNames=Z1039, ECs0894;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: In the presence of manganese, represses expression of mntH
CC       and mntS. Up-regulates expression of mntP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: It contains an N-terminal DNA-binding domain and a metal-
CC       binding domain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG55189.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB34317.1; -; Genomic_DNA.
DR   PIR; A85591; A85591.
DR   PIR; F90740; F90740.
DR   RefSeq; NP_308921.1; NC_002695.1.
DR   RefSeq; WP_000091008.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X7U4; -.
DR   SMR; Q8X7U4; -.
DR   STRING; 155864.EDL933_0940; -.
DR   EnsemblBacteria; AAG55189; AAG55189; Z1039.
DR   EnsemblBacteria; BAB34317; BAB34317; ECs_0894.
DR   GeneID; 917636; -.
DR   KEGG; ece:Z1039; -.
DR   KEGG; ecs:ECs_0894; -.
DR   PATRIC; fig|386585.9.peg.1009; -.
DR   eggNOG; COG1321; Bacteria.
DR   HOGENOM; CLU_069532_2_0_6; -.
DR   OMA; SWDAIDR; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Manganese; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..155
FT                   /note="Transcriptional regulator MntR"
FT                   /id="PRO_0000201111"
FT   DOMAIN          34..95
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   155 AA;  17670 MW;  C374ED58F1BDC699 CRC64;
     MSRRAGTPTA KKVTQLVNEE EHVEGFRQVR EAHRRELIDD YVELISDLIR EVGEARQVDM
     AARLGVSQPT VAKMLKRLAT MGLIEMIPWR GVFLTAEGEK LAQESRERHQ IVENFLLVLG
     VSPEIARRDA EGMEHHVSEE TLDAFRLFTQ KHGAK