ID   MNTR_SALTI              Reviewed;         157 AA.
AC   P67711; Q8XH22;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Transcriptional regulator MntR;
DE   AltName: Full=Manganese transport regulator;
GN   Name=mntR; OrderedLocusNames=STY0876, t2052;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: In the presence of manganese, represses expression of mntH
CC       and mntS. Up-regulates expression of mntP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: It contains an N-terminal DNA-binding domain and a metal-
CC       binding domain. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DtxR/MntR family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD05283.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO69675.1; -; Genomic_DNA.
DR   RefSeq; NP_455371.1; NC_003198.1.
DR   RefSeq; WP_000533542.1; NZ_WSUR01000019.1.
DR   AlphaFoldDB; P67711; -.
DR   SMR; P67711; -.
DR   STRING; 220341.16502047; -.
DR   EnsemblBacteria; AAO69675; AAO69675; t2052.
DR   KEGG; stt:t2052; -.
DR   KEGG; sty:STY0876; -.
DR   PATRIC; fig|220341.7.peg.884; -.
DR   eggNOG; COG1321; Bacteria.
DR   HOGENOM; CLU_069532_2_0_6; -.
DR   OMA; SWDAIDR; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.60.10; -; 1.
DR   InterPro; IPR001367; Fe_dep_repressor.
DR   InterPro; IPR036421; Fe_dep_repressor_sf.
DR   InterPro; IPR022687; HTH_DTXR.
DR   InterPro; IPR022689; Iron_dep_repressor.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF02742; Fe_dep_repr_C; 1.
DR   Pfam; PF01325; Fe_dep_repress; 1.
DR   SMART; SM00529; HTH_DTXR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47979; SSF47979; 1.
DR   PROSITE; PS50944; HTH_DTXR; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Manganese; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..157
FT                   /note="Transcriptional regulator MntR"
FT                   /id="PRO_0000201114"
FT   DOMAIN          34..95
FT                   /note="HTH dtxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00296"
SQ   SEQUENCE   157 AA;  17727 MW;  01E14972776D2A77 CRC64;
     MGRRAGTPTT KKVTQLVNVE EHVEGFRQVR EAHRRELIDD YVELISDLII EVGEARQVDM
     AARLGVSQPT VAKMLKRLAS LGFIQMIPWR GVFLTPEGEK LAQESRERHQ IVENFLLVLG
     VSPEIARRDA EGMEHHVSQE TLDAFLAFTQ QHGTSAE