ID   MNTS_ECOLI              Reviewed;          42 AA.
AC   P0DKB3; U6BY08;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Small protein MntS;
GN   Name=mntS; Synonyms=rybA; OrderedLocusNames=b4705, JW0800.1;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [3]
RP   IDENTIFICATION, FUNCTION IN MANGANESE HOMEOSTASIS, INDUCTION, AND GENE
RP   NAME.
RX   PubMed=21908668; DOI=10.1128/jb.05872-11;
RA   Waters L.S., Sandoval M., Storz G.;
RT   "The Escherichia coli MntR miniregulon includes genes encoding a small
RT   protein and an efflux pump required for manganese homeostasis.";
RL   J. Bacteriol. 193:5887-5897(2011).
RN   [4]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=21778229; DOI=10.1074/jbc.m111.245696;
RA   Fontaine F., Fuchs R.T., Storz G.;
RT   "Membrane localization of small proteins in Escherichia coli.";
RL   J. Biol. Chem. 286:32464-32474(2011).
CC   -!- FUNCTION: Required for repression of mntH by MntR. May function as a
CC       chaperone that makes manganese more available by delivering it to the
CC       necessary cellular locations when manganese is limiting.
CC       {ECO:0000269|PubMed:21908668}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778229}. Note=May
CC       be loosely associated with the inner membrane.
CC   -!- INDUCTION: Repressed by MntR in response to manganese.
CC       {ECO:0000269|PubMed:21908668}.
CC   -!- CAUTION: MntS mRNA was originally thought to be an sRNA. {ECO:0000305}.
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DR   EMBL; U00096; AHA50631.1; -; Genomic_DNA.
DR   EMBL; AP009048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_001001761.1; NZ_STEB01000019.1.
DR   RefSeq; YP_009029995.1; NC_000913.3.
DR   AlphaFoldDB; P0DKB3; -.
DR   SMR; P0DKB3; -.
DR   STRING; 511145.b4705; -.
DR   PRIDE; P0DKB3; -.
DR   EnsemblBacteria; AHA50631; AHA50631; b4705.
DR   GeneID; 14678509; -.
DR   GeneID; 67413855; -.
DR   KEGG; eco:b4705; -.
DR   PATRIC; fig|1411691.4.peg.1462; -.
DR   eggNOG; ENOG5033AZ9; Bacteria.
DR   BioCyc; EcoCyc:MON0-4216; -.
DR   PRO; PR:P0DKB3; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030026; P:cellular manganese ion homeostasis; IMP:EcoCyc.
DR   GO; GO:0071287; P:cellular response to manganese ion; IEP:EcoCyc.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..42
FT                   /note="Small protein MntS"
FT                   /id="PRO_0000419287"
SQ   SEQUENCE   42 AA;  5031 MW;  963F9247AFA10A2A CRC64;
     MNEFKRCMRV FSHSPFKVRL MLLSMLCDMV NNKPQQDKPS DK