MNX1_MOUSE
ID MNX1_MOUSE Reviewed; 404 AA.
AC Q9QZW9; E9QPC0;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Motor neuron and pancreas homeobox protein 1;
DE AltName: Full=Homeobox protein HB9;
GN Name=Mnx1; Synonyms=Hlxb9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Swiss Webster / NIH;
RX PubMed=10471502; DOI=10.1038/12674;
RA Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H.;
RT "Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-
RT deficient mice.";
RL Nat. Genet. 23:71-75(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Putative transcription factor involved in pancreas
CC development and function.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR EMBL; AF153046; AAD49613.1; -; mRNA.
DR EMBL; AC164700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS19150.1; -.
DR AlphaFoldDB; Q9QZW9; -.
DR SMR; Q9QZW9; -.
DR STRING; 10090.ENSMUSP00000129503; -.
DR iPTMnet; Q9QZW9; -.
DR PhosphoSitePlus; Q9QZW9; -.
DR MaxQB; Q9QZW9; -.
DR PaxDb; Q9QZW9; -.
DR PRIDE; Q9QZW9; -.
DR Antibodypedia; 33173; 222 antibodies from 35 providers.
DR Ensembl; ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.
DR MGI; MGI:109160; Mnx1.
DR VEuPathDB; HostDB:ENSMUSG00000001566; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000160059; -.
DR InParanoid; Q9QZW9; -.
DR PRO; PR:Q9QZW9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9QZW9; protein.
DR Bgee; ENSMUSG00000001566; Expressed in lumbar subsegment of spinal cord and 39 other tissues.
DR ExpressionAtlas; Q9QZW9; baseline and differential.
DR Genevisible; Q9QZW9; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IMP:MGI.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
DR GO; GO:0060539; P:diaphragm development; IMP:MGI.
DR GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
DR GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
DR GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
DR GO; GO:0021675; P:nerve development; IMP:MGI.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0048812; P:neuron projection morphogenesis; IMP:MGI.
DR GO; GO:0031016; P:pancreas development; IMP:MGI.
DR GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR GO; GO:0060541; P:respiratory system development; IMP:MGI.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042768; MNX1/Ceh-12.
DR PANTHER; PTHR24335; PTHR24335; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Acetylation; DNA-binding; Homeobox; Nucleus; Phosphoprotein;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..404
FT /note="Motor neuron and pancreas homeobox protein 1"
FT /id="PRO_0000048906"
FT DNA_BIND 241..300
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 36..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P50219"
FT MOD_RES 78
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50219"
FT MOD_RES 80
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P50219"
FT CONFLICT 232
FT /note="E -> Q (in Ref. 1; AAD49613)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 41331 MW; 1D2B56CD645DB50A CRC64;
MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG TSSGASRSCS
PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA GGGGGAAGGP GTPHHHAHPG
AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYSYSAAA AAAALAGQHP
ALSYSYPQVQ GAHPAHPADP IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK
CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK
KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD LRDSDPDEDE
DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ PLPQ
