MO1_ARATH
ID MO1_ARATH Reviewed; 397 AA.
AC O81815; F4JK84; O23427;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Monooxygenase 1 {ECO:0000303|PubMed:10216258};
DE Short=AtMO1 {ECO:0000303|PubMed:10216258};
DE EC=1.14.13.-;
GN Name=MO1 {ECO:0000303|PubMed:10216258};
GN OrderedLocusNames=At4g15760 {ECO:0000312|Araport:AT4G15760};
GN ORFNames=dl3920c {ECO:0000312|EMBL:CAB10354.1},
GN FCAALL.376 {ECO:0000312|EMBL:CAB78618.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=10216258; DOI=10.1016/s0378-1119(99)00073-6;
RA Aubourg S., Picaud A., Kreis M., Lecharny A.;
RT "Structure and expression of three src2 homologues and a novel subfamily of
RT flavoprotein monooxygenase genes revealed by the analysis of a 25kb
RT fragment from Arabidopsis thaliana chromosome IV.";
RL Gene 230:197-205(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP INDUCTION BY A.BRASSICICOLA.
RC STRAIN=cv. Columbia, and cv. Di-G;
RX PubMed=19296849; DOI=10.1186/1471-2229-9-31;
RA Mukherjee A.K., Lev S., Gepstein S., Horwitz B.A.;
RT "A compatible interaction of Alternaria brassicicola with Arabidopsis
RT thaliana ecotype DiG: evidence for a specific transcriptional signature.";
RL BMC Plant Biol. 9:31-31(2009).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000250|UniProtKB:Q5EXK1};
CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:Q5EXK1}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves, flowers and
CC siliques. {ECO:0000269|PubMed:10216258}.
CC -!- INDUCTION: Induced by A.brassicicola, especially in cv. Di-G during
CC compatible interaction. {ECO:0000269|PubMed:19296849}.
CC -!- SIMILARITY: Belongs to the 3-hydroxybenzoate 6-hydroxylase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE83647.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB10354.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78618.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ007587; CAA07574.1; -; mRNA.
DR EMBL; Z97339; CAB10354.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161542; CAB78618.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83647.1; ALT_INIT; Genomic_DNA.
DR EMBL; AK175153; BAD42916.1; -; mRNA.
DR EMBL; AK175199; BAD42962.1; -; mRNA.
DR EMBL; AK175294; BAD43057.1; -; mRNA.
DR EMBL; AK175336; BAD43099.1; -; mRNA.
DR EMBL; AK175354; BAD43117.1; -; mRNA.
DR EMBL; AK175412; BAD43175.1; -; mRNA.
DR EMBL; AK175466; BAD43229.1; -; mRNA.
DR EMBL; AK175487; BAD43250.1; -; mRNA.
DR EMBL; AK176335; BAD44098.1; -; mRNA.
DR EMBL; AK176434; BAD44197.1; -; mRNA.
DR EMBL; AK176523; BAD44286.1; -; mRNA.
DR EMBL; AK176601; BAD44364.1; -; mRNA.
DR EMBL; AK176701; BAD44464.1; -; mRNA.
DR EMBL; AK176715; BAD44478.1; -; mRNA.
DR EMBL; AK176742; BAD44505.1; -; mRNA.
DR EMBL; AK176746; BAD44509.1; -; mRNA.
DR PIR; H71422; H71422.
DR PIR; T51603; T51603.
DR RefSeq; NP_193311.6; NM_117667.9.
DR AlphaFoldDB; O81815; -.
DR SMR; O81815; -.
DR STRING; 3702.AT4G15760.1; -.
DR SwissPalm; O81815; -.
DR PRIDE; O81815; -.
DR ProteomicsDB; 238344; -.
DR EnsemblPlants; AT4G15760.1; AT4G15760.1; AT4G15760.
DR GeneID; 827255; -.
DR Gramene; AT4G15760.1; AT4G15760.1; AT4G15760.
DR KEGG; ath:AT4G15760; -.
DR Araport; AT4G15760; -.
DR TAIR; locus:2130694; AT4G15760.
DR eggNOG; KOG2614; Eukaryota.
DR PhylomeDB; O81815; -.
DR PRO; PR:O81815; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O81815; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR Gene3D; 3.50.50.60; -; 1.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR044560; MO/PqsH.
DR PANTHER; PTHR45934; PTHR45934; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 2: Evidence at transcript level;
KW FAD; Flavoprotein; Monooxygenase; Oxidoreductase; Reference proteome.
FT CHAIN 1..397
FT /note="Monooxygenase 1"
FT /id="PRO_0000441114"
SQ SEQUENCE 397 AA; 43979 MW; 5E36ED911C194A9A CRC64;
MEEIGIVIVG GGIAGLATSI ALHRKGIKSV VLERAEKVRS EGAGIGTLSN GWRALDQLGV
GDRLRLNSSL IHKARTMLIE NGKKREFVSN IVDEARCIKR NDLVEALSDA LPKGTIRFGS
HIVSIEQDKT TLFPVVHLAN GNSIKAKVLI GCDGANSIVS DYLQLNPKKA FACRAVRGFT
KYPNGHGFPQ EVLRIKQGNV LIGRLPLTDN QVFWFLVHMQ DNNHNGKDQE SIANLCRKWA
DDLSEDWKEM VKICNVESLT LTHLRYRAPS EIMLGKFRRG TVTVAGDAMH VMGPFLAQGG
SAALEDAVVL ARCLARKVGP DHGDLLKDCS MKNIEEAIDE YVDERRMRLL GLSVQTYLTG
RSLQTSSKVL RLMFIALLLL LFGRDQIRHT RYDCGRL
