ID   MO25M_CAEEL             Reviewed;         338 AA.
AC   O18211;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=MO25-like protein 2;
GN   Name=mop-25.2; ORFNames=Y53C12A.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=17676955; DOI=10.1371/journal.pgen.0030128;
RA   O'Rourke S.M., Dorfman M.D., Carter J.C., Bowerman B.;
RT   "Dynein modifiers in C. elegans: light chains suppress conditional heavy
RT   chain mutants.";
RL   PLoS Genet. 3:E128-E128(2007).
RN   [3]
RP   FUNCTION.
RX   PubMed=22801495; DOI=10.1038/nature11240;
RA   Denning D.P., Hatch V., Horvitz H.R.;
RT   "Programmed elimination of cells by caspase-independent cell extrusion in
RT   C. elegans.";
RL   Nature 488:226-230(2012).
RN   [4] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=23267054; DOI=10.1534/genetics.112.148106;
RA   Chien S.C., Brinkmann E.M., Teuliere J., Garriga G.;
RT   "Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity
RT   pathway to promote asymmetric neuroblast divisions.";
RL   Genetics 193:897-909(2013).
CC   -!- FUNCTION: Regulates asymmetric cell division in Q.p neuroblast lineage
CC       (PubMed:23267054). Plays a role in cell shedding during embryogenesis
CC       (PubMed:22801495). {ECO:0000269|PubMed:22801495,
CC       ECO:0000269|PubMed:23267054}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000269|PubMed:17676955}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in the production
CC       of additional AVM/PVM neuronal precursors.
CC       {ECO:0000269|PubMed:23267054}.
CC   -!- SIMILARITY: Belongs to the Mo25 family. {ECO:0000305}.
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DR   EMBL; Z99277; CAB16486.1; -; Genomic_DNA.
DR   PIR; T27129; T27129.
DR   RefSeq; NP_496092.1; NM_063691.5.
DR   AlphaFoldDB; O18211; -.
DR   SMR; O18211; -.
DR   BioGRID; 39850; 3.
DR   STRING; 6239.Y53C12A.4.1; -.
DR   EPD; O18211; -.
DR   PaxDb; O18211; -.
DR   PeptideAtlas; O18211; -.
DR   PRIDE; O18211; -.
DR   EnsemblMetazoa; Y53C12A.4.1; Y53C12A.4.1; WBGene00013140.
DR   GeneID; 174527; -.
DR   KEGG; cel:CELE_Y53C12A.4; -.
DR   CTD; 174527; -.
DR   WormBase; Y53C12A.4; CE14890; WBGene00013140; mop-25.2.
DR   eggNOG; KOG1566; Eukaryota.
DR   GeneTree; ENSGT00390000004360; -.
DR   HOGENOM; CLU_035755_0_0_1; -.
DR   InParanoid; O18211; -.
DR   OMA; FCFFRYV; -.
DR   OrthoDB; 865327at2759; -.
DR   PhylomeDB; O18211; -.
DR   Reactome; R-CEL-6798695; Neutrophil degranulation.
DR   PRO; PR:O18211; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00013140; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0055059; P:asymmetric neuroblast division; IMP:WormBase.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013878; Mo25.
DR   PANTHER; PTHR10182; PTHR10182; 1.
DR   Pfam; PF08569; Mo25; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..338
FT                   /note="MO25-like protein 2"
FT                   /id="PRO_0000209830"
SQ   SEQUENCE   338 AA;  39431 MW;  1D0C34A35D9116F5 CRC64;
     MLKPLFGKAD KTPADVVKNL RDALLVIDRH GTNTSERKVE KAIEETAKML ALAKTFIYGS
     DANEPNNEQV TQLAQEVYNA NVLPMLIKHL HKFEFECKKD VASVFNNLLR RQIGTRSPTV
     EYLAARPEIL ITLLLGYEQP DIALTCGSML REAVRHEHLA RIVLYSEYFQ RFFVFVQSDV
     FDIATDAFST FKDLMTKHKN MCAEYLDNNY DRFFGQYSAL TNSENYVTRR QSLKLLGELL
     LDRHNFSTMN KYITSPENLK TVMELLRDKR RNIQYEAFHV FKIFVANPNK PRPITDILTR
     NRDKLVEFLT AFHNDRTNDE QFNDEKAYLI KQIQELRV