ID   MO25_DROME              Reviewed;         339 AA.
AC   P91891; Q540S2; Q9VV85;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   14-AUG-2001, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Protein Mo25;
DE   AltName: Full=dMo25;
GN   Name=Mo25; ORFNames=CG4083;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8672247; DOI=10.1089/dna.1996.15.505;
RA   Nozaki M., Onishi Y., Togashi S., Miyamoto H.;
RT   "Molecular characterization of the Drosophila Mo25 gene, which is conserved
RT   among Drosophila, mouse, and yeast.";
RL   DNA Cell Biol. 15:505-509(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SIMILARITY: Belongs to the Mo25 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB000402; BAA19098.1; -; mRNA.
DR   EMBL; AE014296; AAF49432.1; -; Genomic_DNA.
DR   EMBL; AY128438; AAM75031.1; -; mRNA.
DR   RefSeq; NP_001261958.1; NM_001275029.1.
DR   RefSeq; NP_524117.1; NM_079393.2.
DR   AlphaFoldDB; P91891; -.
DR   SMR; P91891; -.
DR   BioGRID; 65158; 3.
DR   STRING; 7227.FBpp0075117; -.
DR   PaxDb; P91891; -.
DR   PRIDE; P91891; -.
DR   DNASU; 39858; -.
DR   EnsemblMetazoa; FBtr0075358; FBpp0075117; FBgn0017572.
DR   EnsemblMetazoa; FBtr0331560; FBpp0303950; FBgn0017572.
DR   GeneID; 39858; -.
DR   KEGG; dme:Dmel_CG4083; -.
DR   UCSC; CG4083-RA; d. melanogaster.
DR   CTD; 39858; -.
DR   FlyBase; FBgn0017572; Mo25.
DR   VEuPathDB; VectorBase:FBgn0017572; -.
DR   eggNOG; KOG1566; Eukaryota.
DR   GeneTree; ENSGT00390000004360; -.
DR   HOGENOM; CLU_035755_0_0_1; -.
DR   InParanoid; P91891; -.
DR   OMA; HLKLCMN; -.
DR   OrthoDB; 865327at2759; -.
DR   PhylomeDB; P91891; -.
DR   Reactome; R-DME-6798695; Neutrophil degranulation.
DR   BioGRID-ORCS; 39858; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 39858; -.
DR   PRO; PR:P91891; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0017572; Expressed in brain and 16 other tissues.
DR   ExpressionAtlas; P91891; baseline and differential.
DR   Genevisible; P91891; DM.
DR   GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013878; Mo25.
DR   PANTHER; PTHR10182; PTHR10182; 1.
DR   Pfam; PF08569; Mo25; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..339
FT                   /note="Protein Mo25"
FT                   /id="PRO_0000209828"
FT   CONFLICT        51
FT                   /note="Y -> H (in Ref. 1; BAA19098)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102
FT                   /note="V -> L (in Ref. 1; BAA19098)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   339 AA;  39385 MW;  5790BD91754C1C74 CRC64;
     MPLFGKSQKS PVELVKSLKE AINALEAGDR KVEKAQEDVS KNLVSIKNML YGSSDAEPPA
     DYVVAQLSQE LYNSNLLLLL IQNLHRIDFE GKKHVALIFN NVLRRQIGTR SPTVEYICTK
     PEILFTLMAG YEDAHPEIAL NSGTMLRECA RYEALAKIML HSDEFFKFFR YVEVSTFDIA
     SDAFSTFKEL LTRHKLLCAE FLDANYDKFF SQHYQRLLNS ENYVTRRQSL KLLGELLLDR
     HNFTVMTRYI SEPENLKLMM NMLKEKSRNI QFEAFHVFKV FVANPNKPKP ILDILLRNQT
     KLVDFLTNFH TDRSEDEQFN DEKAYLIKQI KELKPLPEA