MO2R2_HUMAN
ID MO2R2_HUMAN Reviewed; 271 AA.
AC Q6Q8B3; Q6WHB7;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Cell surface glycoprotein CD200 receptor 2;
DE AltName: Full=CD200 cell surface glycoprotein receptor-like 2;
DE Short=CD200 receptor-like 2;
DE Short=HuCD200R2;
DE AltName: Full=CD200 cell surface glycoprotein receptor-like a;
DE Short=CD200RLa;
DE AltName: Full=Cell surface glycoprotein CD200 receptor 1-like;
DE AltName: Full=Cell surface glycoprotein OX2 receptor 2;
DE Flags: Precursor;
GN Name=CD200R1L; Synonyms=CD200R2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Peripheral blood;
RX PubMed=12960329; DOI=10.4049/jimmunol.171.6.3034;
RA Wright G.J., Cherwinski H., Foster-Cuevas M., Brooke G., Puklavec M.J.,
RA Bigler M., Song Y., Jenmalm M., Gorman D., McClanahan T., Liu M.-R.,
RA Brown M.H., Sedgwick J.D., Phillips J.H., Barclay A.N.;
RT "Characterization of the CD200 receptor family in mice and humans and their
RT interactions with CD200.";
RL J. Immunol. 171:3034-3046(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT LEU-113.
RX PubMed=15274657; DOI=10.1111/j.1600-0897.2004.00192.x;
RA Gorczynski R.M., Chen Z., Clark D.A., Kai Y., Lee L., Nachman J., Wong S.,
RA Marsden P.;
RT "Structural and functional heterogeneity in the CD200R family of
RT immunoregulatory molecules and their expression at the feto-maternal
RT interface.";
RL Am. J. Reprod. Immunol. 52:147-163(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
CC -!- FUNCTION: May be a receptor for the CD200/OX2 cell surface
CC glycoprotein. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6Q8B3; Q99801: NKX3-1; NbExp=3; IntAct=EBI-18552964, EBI-1385894;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6Q8B3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6Q8B3-2; Sequence=VSP_035002;
CC -!- SIMILARITY: Belongs to the CD200R family. {ECO:0000305}.
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DR EMBL; AY284976; AAQ19773.1; -; mRNA.
DR EMBL; AY552790; AAT00538.1; -; mRNA.
DR EMBL; AC074044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092892; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS43131.1; -. [Q6Q8B3-1]
DR CCDS; CCDS56267.1; -. [Q6Q8B3-2]
DR RefSeq; NP_001008784.2; NM_001008784.2. [Q6Q8B3-1]
DR RefSeq; NP_001186144.1; NM_001199215.1. [Q6Q8B3-2]
DR RefSeq; XP_011511065.1; XM_011512763.2.
DR RefSeq; XP_016861789.1; XM_017006300.1.
DR AlphaFoldDB; Q6Q8B3; -.
DR SMR; Q6Q8B3; -.
DR BioGRID; 131325; 2.
DR IntAct; Q6Q8B3; 2.
DR STRING; 9606.ENSP00000381272; -.
DR GlyGen; Q6Q8B3; 6 sites.
DR iPTMnet; Q6Q8B3; -.
DR PhosphoSitePlus; Q6Q8B3; -.
DR BioMuta; CD200R1L; -.
DR DMDM; 205829216; -.
DR MassIVE; Q6Q8B3; -.
DR PaxDb; Q6Q8B3; -.
DR PeptideAtlas; Q6Q8B3; -.
DR PRIDE; Q6Q8B3; -.
DR Antibodypedia; 58040; 132 antibodies from 16 providers.
DR DNASU; 344807; -.
DR Ensembl; ENST00000398214.5; ENSP00000381272.1; ENSG00000206531.11. [Q6Q8B3-1]
DR Ensembl; ENST00000488794.6; ENSP00000418413.1; ENSG00000206531.11. [Q6Q8B3-2]
DR GeneID; 344807; -.
DR KEGG; hsa:344807; -.
DR MANE-Select; ENST00000488794.6; ENSP00000418413.1; NM_001199215.3; NP_001186144.1. [Q6Q8B3-2]
DR UCSC; uc003dzi.1; human. [Q6Q8B3-1]
DR CTD; 344807; -.
DR DisGeNET; 344807; -.
DR GeneCards; CD200R1L; -.
DR HGNC; HGNC:24665; CD200R1L.
DR HPA; ENSG00000206531; Tissue enriched (testis).
DR neXtProt; NX_Q6Q8B3; -.
DR OpenTargets; ENSG00000206531; -.
DR PharmGKB; PA164717784; -.
DR VEuPathDB; HostDB:ENSG00000206531; -.
DR eggNOG; ENOG502S9IV; Eukaryota.
DR GeneTree; ENSGT00390000014496; -.
DR InParanoid; Q6Q8B3; -.
DR OMA; WKIRPRT; -.
DR OrthoDB; 993609at2759; -.
DR PhylomeDB; Q6Q8B3; -.
DR TreeFam; TF335960; -.
DR PathwayCommons; Q6Q8B3; -.
DR SignaLink; Q6Q8B3; -.
DR BioGRID-ORCS; 344807; 13 hits in 1060 CRISPR screens.
DR ChiTaRS; CD200R1L; human.
DR GenomeRNAi; 344807; -.
DR Pharos; Q6Q8B3; Tdark.
DR PRO; PR:Q6Q8B3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6Q8B3; protein.
DR Bgee; ENSG00000206531; Expressed in testis and 18 other tissues.
DR ExpressionAtlas; Q6Q8B3; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0150077; P:regulation of neuroinflammatory response; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR040012; CD200R.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR21462; PTHR21462; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..271
FT /note="Cell surface glycoprotein CD200 receptor 2"
FT /id="PRO_0000346451"
FT TOPO_DOM 24..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 46..132
FT /note="Ig-like V-type"
FT DOMAIN 133..221
FT /note="Ig-like C2-type"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 92
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 160..209
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 1..21
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15274657"
FT /id="VSP_035002"
FT VARIANT 113
FT /note="R -> L (in dbSNP:rs4682119)"
FT /evidence="ECO:0000269|PubMed:15274657"
FT /id="VAR_045897"
SQ SEQUENCE 271 AA; 29920 MW; 9D8E3074F7D34F90 CRC64;
MSAPRLLISI IIMVSASSSS CMGGKQMTQN YSTIFAEGNI SQPVLMDINA VLCCPPIALR
NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTVERITW VSRPDQNSDL QIRPVDTTHD
GYYRGIVVTP DGNFHRGYHL QVLVTPEVNL FQSRNITAVC KAVTGKPAAQ ISWIPEGSIL
ATKQEYWGNG TVTVKSTCPW EGHKSTVTCH VSHLTGNKSL SVKLNSGLRT SGSPALSLLI
ILYVKLSLFV VILVTTGFVF FQRINHVRKV L
